HOME >> MEDICINE >> NEWS
Glucose levels trigger compensation for type 2 diabetics

Many individuals with type 2 diabetes are diabetic because the cells of their body no longer respond to the hormone insulin, which is crucial for lowering blood sugar levels (blood glucose levels). However, before individuals become clinically diabetic their body tries to compensate for the increasing resistance to the effects of insulin by increasing both the amount of insulin secreted and the mass of insulin-secreting cells (beta cells) in the pancreas. Several factors have been shown to induce an increase in beta-cell mass, but exactly what triggers this in individuals consuming a high-fat diet has not been clearly established.

In a study appearing in the January issue of the Journal of Clinical Investigation, Takashi Kadowaki and colleagues from the University of Tokyo, Japan, show that in mice with high-fat dietinduced insulin resistance, changes in glucose concentration are likely to be the main trigger of increased beta-cell mass. The beta-cell mass of mice expressing only one copy of the gene encoding the sensor of blood glucose levels, GCK (Gck-/- mice), showed little increase compared with wild-type mice fed a high-fat diet, and the mice developed diabetes. One important mediator of the beta-cell mass increase downstream of GCK sensing increased blood glucose levels, and was shown to be IRS2, as expression of IRS2 in Gck-/- mice partially prevented diabetes by increasing beta-cell mass. The authors therefore suggest that novel strategies to increase beta-cell mass to treat type 2 diabetes and overcome high-fat dietinduced insulin resistance might be developed if the mechanism linking GCK and IRS2 can be determined. However, in an accompanying commentary, Gordon Weir and Susan Bonner-Weir from the Joslin Diabetes Center remind us that before we develop new therapeutics "it is essential that glucose signals involved in beta-cell replication in both health and disease be carefully defined."


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2007


Page: 1

Related medicine news :

1. Even low levels of weekly exercise drive down blood pressure
2. Low hospital staff levels increase infection rates
3. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
4. Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
5. Exercise may slightly boost good cholesterol levels
6. Coffee consumption may lower blood uric acid levels -- the precursor of gout
7. Different type of iron supplement is better at boosting iron levels
8. Yoga and elevated brain GABA levels
9. Statin use linked with decreased prostate cancer mortality rates, lower PSA levels
10. Low physical activity can improve fitness levels for sedentary, overweight postmenopausal women
11. Neglected epidemic of chronic lung disease; childhood conditions affect adult progesterone levels

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Thank you to all who attended ... , This event was exclusive to providers and offered an opportunity to collaborate ... place at the Manchester Grand Hyatt where attendees gathered for a lively discussion on ...
(Date:3/28/2017)... ... ... “A Prophets Bones”: a thrilling adventure that reveals the mystery of Kevin’s purpose. “A Prophets ... parents and teachers had asked of him that he had neglected to do, but this ... Almighty Creator. There were some who would have felt themselves to be special and better ...
(Date:3/27/2017)... , ... March 27, 2017 , ... New patients who ... for leading sleep apnea treatment, with or without a referral. Sleep apnea is often ... can include daytime sleepiness, morning headaches and chronic snoring. , Dr. Braasch seeks ...
(Date:3/27/2017)... ... 27, 2017 , ... Drs. Bruce Trimble and Michelle Parker ... a referral. Trimble Dental offers a variety of services to meet each patient’s ... patients have discolored, crooked or missing teeth in Eau Claire, WI, Drs. Trimble ...
(Date:3/27/2017)... ... ... Drs. Justin Kolnick, Kara Diamond, Randall Barton, Keith Hope and Bilal Chaudhry ... this treatment plays in protecting oral health, along with the benefits of receiving ... a root canal in White Plains, NY or their second location in Mt. Kisco, ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... The global surgical sealants ... of USD 4.5 billion by 2025, according to a ... of injured tissues post operation is a major step ... in 3% to 15% of cases and are considered ... third of postoperative deaths in patients. Surgical sealants and ...
(Date:3/27/2017)... 2017 Summary This report ... and its partnering interests and activities since 2010. Description ... in-depth insight into the partnering activity of one of the ... reports are prepared upon purchase to ensure inclusion of the ... The report will be delivered in PDF format within 1 ...
(Date:3/27/2017)... March 27, 2017  Cryoport, Inc. (NASDAQ: CYRX, CYRXW) ... to offer shares of common stock in an underwritten ... file with the Securities and Exchange Commission (the "SEC"). ... and there can be no assurance as to whether ... to the actual size or terms of the offering. ...
Breaking Medicine Technology:
Cached News: