HOME >> MEDICINE >> NEWS
Glucose levels trigger compensation for type 2 diabetics

Many individuals with type 2 diabetes are diabetic because the cells of their body no longer respond to the hormone insulin, which is crucial for lowering blood sugar levels (blood glucose levels). However, before individuals become clinically diabetic their body tries to compensate for the increasing resistance to the effects of insulin by increasing both the amount of insulin secreted and the mass of insulin-secreting cells (beta cells) in the pancreas. Several factors have been shown to induce an increase in beta-cell mass, but exactly what triggers this in individuals consuming a high-fat diet has not been clearly established.

In a study appearing in the January issue of the Journal of Clinical Investigation, Takashi Kadowaki and colleagues from the University of Tokyo, Japan, show that in mice with high-fat dietinduced insulin resistance, changes in glucose concentration are likely to be the main trigger of increased beta-cell mass. The beta-cell mass of mice expressing only one copy of the gene encoding the sensor of blood glucose levels, GCK (Gck-/- mice), showed little increase compared with wild-type mice fed a high-fat diet, and the mice developed diabetes. One important mediator of the beta-cell mass increase downstream of GCK sensing increased blood glucose levels, and was shown to be IRS2, as expression of IRS2 in Gck-/- mice partially prevented diabetes by increasing beta-cell mass. The authors therefore suggest that novel strategies to increase beta-cell mass to treat type 2 diabetes and overcome high-fat dietinduced insulin resistance might be developed if the mechanism linking GCK and IRS2 can be determined. However, in an accompanying commentary, Gordon Weir and Susan Bonner-Weir from the Joslin Diabetes Center remind us that before we develop new therapeutics "it is essential that glucose signals involved in beta-cell replication in both health and disease be carefully defined."


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2007


Page: 1

Related medicine news :

1. Even low levels of weekly exercise drive down blood pressure
2. Low hospital staff levels increase infection rates
3. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
4. Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
5. Exercise may slightly boost good cholesterol levels
6. Coffee consumption may lower blood uric acid levels -- the precursor of gout
7. Different type of iron supplement is better at boosting iron levels
8. Yoga and elevated brain GABA levels
9. Statin use linked with decreased prostate cancer mortality rates, lower PSA levels
10. Low physical activity can improve fitness levels for sedentary, overweight postmenopausal women
11. Neglected epidemic of chronic lung disease; childhood conditions affect adult progesterone levels

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... Palm Beach, FL (PRWEB) , ... April 28, 2016 , ... ... for the spring season. Smart pots are frequently used by professional organic farmers and ... for growers to order their supply of fabric pots. Our goal is to offer ...
(Date:4/28/2016)... ... April 28, 2016 , ... Cognizin® ... VitaFoods 2016. , Nominated in the Healthy Ageing category, Cognizin® is being considered ... The Healthy Ageing division can include everything from antioxidants, lipids, proteins, and botanicals. ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... and Collaboration Platform™ , today announced a new Residency Education & Collaboration ... to medical knowledge, educational resources, and a host of collaboration tools designed ...
(Date:4/28/2016)... ... April 28, 2016 , ... Metabolic Nutrition today announced ... week’s 2016 Europa Games Get Fit and Sports Expo in Orlando, Florida. ... Orlando Expo coming up April 29-30, was selected as the perfect event to introduce ...
(Date:4/28/2016)... ... April 28, 2016 , ... For the 10,000 Americans who turn ... an important part of overall well-being: mental health. Now, a new book—Staying Sharp For ... aging and “cognitive vitality,” which can include everything from honing your memory and managing ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... Avril 2016   ... +5% sur le trimestre, soutenu par une croissance ... Croissance de +16% des ventes aux hôpitaux ... Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur ... aujourd,hui son chiffre d,affaires pour le premier trimestre ...
(Date:4/27/2016)...   Zillion Group today announced the ... which specializes in live video consultation. Turning content, ... Zillion enables companies to realize the true potential ... control of their health. Zillion,s ... one-to-one, group and webcast scheduled or on-demand – ...
(Date:4/27/2016)... 27, 2016 Research ... "Global Anesthesia Disposables Market 2016-2020"  report to ... ) ,The global anesthesia disposables market is ... 4.03% during the period 2016-2020.  ... to patients, safety. Organizations like the CDC ...
Breaking Medicine Technology:
Cached News: