HOME >> MEDICINE >> NEWS
Glucose levels trigger compensation for type 2 diabetics

Many individuals with type 2 diabetes are diabetic because the cells of their body no longer respond to the hormone insulin, which is crucial for lowering blood sugar levels (blood glucose levels). However, before individuals become clinically diabetic their body tries to compensate for the increasing resistance to the effects of insulin by increasing both the amount of insulin secreted and the mass of insulin-secreting cells (beta cells) in the pancreas. Several factors have been shown to induce an increase in beta-cell mass, but exactly what triggers this in individuals consuming a high-fat diet has not been clearly established.

In a study appearing in the January issue of the Journal of Clinical Investigation, Takashi Kadowaki and colleagues from the University of Tokyo, Japan, show that in mice with high-fat dietinduced insulin resistance, changes in glucose concentration are likely to be the main trigger of increased beta-cell mass. The beta-cell mass of mice expressing only one copy of the gene encoding the sensor of blood glucose levels, GCK (Gck-/- mice), showed little increase compared with wild-type mice fed a high-fat diet, and the mice developed diabetes. One important mediator of the beta-cell mass increase downstream of GCK sensing increased blood glucose levels, and was shown to be IRS2, as expression of IRS2 in Gck-/- mice partially prevented diabetes by increasing beta-cell mass. The authors therefore suggest that novel strategies to increase beta-cell mass to treat type 2 diabetes and overcome high-fat dietinduced insulin resistance might be developed if the mechanism linking GCK and IRS2 can be determined. However, in an accompanying commentary, Gordon Weir and Susan Bonner-Weir from the Joslin Diabetes Center remind us that before we develop new therapeutics "it is essential that glucose signals involved in beta-cell replication in both health and disease be carefully defined."


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2007


Page: 1

Related medicine news :

1. Even low levels of weekly exercise drive down blood pressure
2. Low hospital staff levels increase infection rates
3. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
4. Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
5. Exercise may slightly boost good cholesterol levels
6. Coffee consumption may lower blood uric acid levels -- the precursor of gout
7. Different type of iron supplement is better at boosting iron levels
8. Yoga and elevated brain GABA levels
9. Statin use linked with decreased prostate cancer mortality rates, lower PSA levels
10. Low physical activity can improve fitness levels for sedentary, overweight postmenopausal women
11. Neglected epidemic of chronic lung disease; childhood conditions affect adult progesterone levels

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Glucose levels trigger compensation for type diabetics

(Date:7/28/2015)... ... 2015 , ... Carol McFarland, PT, PhD, OCS focuses entirely ... specific rehabilitation exercises and treatment protocols in the PTA OT PT Continuing ... interview conducted by Carol with a board certified neurosurgeon. Specific case studies are ...
(Date:7/28/2015)... SD (PRWEB) , ... July 28, 2015 , ... Peter Forbes, President of the Veterans ... of the Vietnam War Inc. and the Veterans Coalition, is spearheading a campaign to help ... , The UVBH teaches Veterans life and trade skills. Forbes and the UVBH assists and ...
(Date:7/27/2015)... ... July 28, 2015 , ... Conducting Advanced Root Cause Analysis ... the Quality of Investigations , **Presented by FDAnews and Learning Plus**, Sept. 16-17, ... been the #1 reason for 483 observations since 1997! , The FDA's enforcement ...
(Date:7/27/2015)... , ... July 28, 2015 , ... The National ... inductee into the NAPW VIP Woman of the Year Circle. She is recognized with ... 200 operating Local Chapters, NAPW is the nation’s leading networking organization exclusively for professional ...
(Date:7/27/2015)... ... July 27, 2015 , ... The FSH ... and incurable disease, facioscapulohumeral muscular dystrophy (FSHD), today announced the introduction of the ... FSHD care guideline is published today. , This new guideline condenses the ...
Breaking Medicine News(10 mins):Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 2Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 3Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 4Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 5Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 6Health News:Veterans Fund of the United States Launches “Adopt A Homeless Veteran” Campaign 2Health News:Veterans Fund of the United States Launches “Adopt A Homeless Veteran” Campaign 3Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 2Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 3Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 4Health News:NAPW Inducts Jane Simmons, Counseling Intern at Omar Bradley Middle School of the Northeast Independent School District , Into its VIP Woman of the Year Circle 2Health News:First-Ever FSHD Evidence-based Care Guideline Published by the American Academy of Neurology 2
(Date:7/27/2015)... HERTFORDSHIRE, England and PITTSBURGH , ... today announced that it will hold its extraordinary general meeting ... Company plc (NYSE: PRGO ; TASE) at the Okura ... Central European Time (CET). Among other agenda ... to vote on the approval, under article 2:107a of the ...
(Date:7/27/2015)... , July 27, 2015  QT Vascular Ltd., ... a global company engaged in the design, assembly and ... treatment of vascular disease, has entered into an agreement ... to US$13.14 million convertible bond investment. This funding will ... its growth to the next milestone. ...
(Date:7/27/2015)... WASHINGTON , July 27, 2015 Even ... Larkin , MD, FACP, NCMP, as scientific co-chair for ... health coalition to serve as an expert voice in ... treatment options for women struggling with Hypoactive Sexual Desire ... "I am honored to join Even ...
Breaking Medicine Technology:Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 2Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 3Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 4Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 5Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 6Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 7Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 8Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 9Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 10QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 2QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 3Dr. Lisa Larkin Joins the Even the Score Coalition as Scientific Co-Chair 2Dr. Lisa Larkin Joins the Even the Score Coalition as Scientific Co-Chair 3
Cached News: