HOME >> MEDICINE >> NEWS
Growth-factor therapy improves endothelial cell production and mobility in arterial disease

ATLANTA-sing a growth factor to stimulate production of circulating endothelial progenitor cells increases the numbers of these vascular regenerative cells, improves mobility, and potentially could improve blood vessel function in patients with peripheral arterial disease (PAD). Scientists at Emory University will present results of a recent clinical trial with endothelial progenitor cells and PAD at the American College of Cardiology Meeting in Atlanta.

Scientists have discovered recently that a healthy crop of circulating endothelial progenitor cells the stem, or precursor cells to those that line the insides of blood vessels is essential to a person's overall cardiovascular health and unimpeded blood circulation. Endothelial cells enable communication between the vessels themselves and circulating blood cells, allowing the blood to flow smoothly.

Individuals with PAD have decreased blood flow to the muscles of the legs, caused by the blockage or narrowing of the arteries, often leading to intermittent pain during walking. Recent studies show that when muscles do not receive enough blood, the body makes its own growth factors that stimulate the bone marrow to release endothelial progenitor cells that home to the damaged vessels and either make new blood vessels or repair the damaged ones.

The Emory scientists hypothesized that if the body uses its own growth factors to stimulate production of endothelial progenitor cells, then endothelial dysfunction in PAD would improve if additional progenitor cells were mobilized through a boost from growth factor therapy.

In a double-blind, placebo-controlled study, the researchers randomized 45 PAD patients to receive either the growth factor GM-CSF (granulocyte macrophage colony stimulating factor) or placebo. Each group of 15 patients received a different dose of GM-CSF or placebo three times a week for three weeks. Before therapy, the PAD patients had severely depressed levels of circulatin
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
12-Mar-2006


Page: 1 2

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
3. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
4. Hormone therapy offers new hope for ovarian cancer patients
5. Borderline personality disorder shows improvements with intensive psychotherapy
6. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
7. Chemotherapy may enhance the effectiveness of brain tumor vaccines
8. Brain-boosting pill alleviates post-chemotherapy fogginess
9. Adding radioimmunotherapy to chemo may help patients with lymphoma
10. Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
11. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... , ... September 01, 2020 , ... ... new practice in Glendale. While the office will be the first to ... augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons at Allegheny ... from Carnegie Mellon University (CMU) to develop a new heart monitoring device designed ... heart surgery. , The AGH/CMU team was recently awarded a “Trailblazer” grant from ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic ... announced today the launch of its integrated, HIPAA compliant, telehealth solution, available to ... practice in under 90 seconds. , According to the U.S. Department of ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back ... donating 10 percent of each hotel room booked with a special new rate code ... Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room ...
(Date:8/28/2020)... ... 2020 , ... WHAT , Hespiro™ is a new type ... including COVID-19, while reducing the need for scarce mechanical ventilators. It not only ... scrubs it free of carbon dioxide in a completely closed “rebreather” system, important ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... AseptiScope, a privately funded San ... of the Year by MedTech Outlook. , “AseptiScope is pleased to receive ... time, clinicians who wear gloves on their hands, goggles on their eyes, covers on ...
(Date:8/26/2020)... , ... August 26, 2020 , ... As the U.S. ... the daily routine for preventing the Coronavirus. Wear a mask, keep your distance, wash ... advocate Dr. Denis Burkitt said it best in 1977, “How much better it is ...
(Date:8/26/2020)... SAN DIEGO (PRWEB) , ... August 26, 2020 ... ... services, announced today the appointment of Claude E. Hooton as President and Chief ... the role of Executive Chairman of the company’s Board of Managers. , ...
Breaking Medicine Technology:
Cached News: