Many of the more than 5 million HIV-infected people living in India have been unable to obtain treatment due to the high cost. With the introduction of generic ART into India in 2000, the price of HIV drugs fell from $778 per month to $100 per month, and eventually declined even further to just $33 per month in 2003.
The drastically lower cost of ART sparked a rise in the number of people seeking--and obtaining--treatment for their infection. Researchers in India and Rhode Island found that in 1996, just 13 percent of the Indian patients who qualified for ART were able to afford it. But that number rose to 22 percent in 2000, and reached 44 percent in 2003.
With the availability of much-needed drugs came better health. Opportunistic infections such as tuberculosis, a common problem for immunocompromised patients, occur at a much lower rate in those receiving ART and its highly active drug counterpart, HAART. Accessible drugs have led, in part, to an 80 percent decline in HIV-related deaths in India between 1997 and 2003.
Despite ART's importance in improving HIV-infected people's health, it can also cause problems. Adverse events, such as rash, nausea, diarrhea, headache and anemia, can arise from antiretroviral use. But are the side effects serious enough to discourage patients from continuing ART? "No. Benefits of HAART outweigh the toxicities, based on our experience in our patients," said lead author Nagalingeswaran Kumarasamy, PhD, of the YRG Centre for AIDS Research and Education in Chennai.