HOME >> MEDICINE >> NEWS
Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

ATLANTA-- Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition.

The hypothalamus serves as the central switching control for neural signals that regulate food intake and energy balance. Hormones such as insulin and leptin, which circulate in the blood plasma, are known to play an important role in regulating the brain's feeding signals, but scientists have not fully understand how these hormones interact with the brain circuitry. Neurotransmitters in the hypothalamus, including GABA (gamma aminobutyric acid), are known to be an important part of the pathway that regulates feeding behavior.

Scientists at Emory University School of Medicine had previously identified the Hap1 protein as crucial for the normal function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice failed to eat after birth. In addition, deleting Hap1 caused degeneration of some neurons in the hypothalamus.

In order to find out more about the function of Hap1 and the neural pathways it employs, a team of scientists from Emory, The Rockefeller University, the Burnham Institute for Medical Research, and the University of California, San Diego, conducted a series of experiments in mice. They found that fasting increased the level of Hap1 in the hypothalamus of the mice and that administering insulin decreased the Hap1 level. Suppressing Hap1 expression through RNA interference reduced mouse food intake and body weight. They also found that reducing Hap1 decreased t
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
9-Apr-2006


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
(Date:4/25/2015)... D.C. (PRWEB) April 25, 2015 The ... Bangladesh Worker Safety issues the following statement following the ... earthquake hit Kathmandu, Nepal, resulting in the deaths of ... massive earthquake were felt across Nepal, Bangladesh, India and ... offer my heartfelt condolences to the people of Nepal ...
(Date:4/25/2015)... York, NY (PRWEB) April 25, 2015 By ... technology and data for the enterprise relying on their judgement ... running smoothly. But according to an article published ... can many times actually be doing a disservice to their ... i’s are dotted and t’s are crossed when it comes ...
(Date:4/25/2015)... Parker and Sons projects growth in 2015. The demand ... alongside the growing economy. As a result, Parker and Sons ... help account for the rising need for heating, cooling, and ... we are enthusiastic about. It means growth for us, and ... and Sons. , Indeed, Parker and Sons has been contributing ...
(Date:4/25/2015)... For thirteen years, the Twin Cities DI ... event in the nation! This year, on May 5th, 2015, ... to take DI Day on the road by supporting the ... ChFC, RHU, DIA, CLTC, Chief Executive Officer at Secura Consultants ... the change by stating, "The first Twin Cities DI Day ...
(Date:4/24/2015)... As the nation recognizes the Month ... of these young men and women, the “Alaska – ... their Families” presents a special training session on Adverse ... a better understanding of the effect of childhood trauma ... – civilian and military – who provide services and ...
Breaking Medicine News(10 mins):Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5Health News:Parker and Sons Plans to Expand in 2015 2Health News:Secura Consultants Takes DI Day On The Road 2Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2
(Date:4/24/2015)... DUBLIN , April 24, 2015  Perrigo Company ... announced its rejection of the unsolicited offer from Mylan ... of the outstanding shares of Perrigo for $60.00 per ... each ordinary Perrigo share (the "Offer").  ... $205.00 per share significantly undervalued the Company and its ...
(Date:4/24/2015)... , April 24, 2015  A new study shows ... costs of drugs used to slow the progression of multiple ... study led by researchers at Oregon Health & Science University ... increase in the number of MS drugs in the marketplace ... lower or stabilized costs for patients who use those drugs. ...
(Date:4/24/2015)... 24, 2015 In today,s ever-changing and ... around the world to access diverse skill sets, ... there are many areas to misstep in the ... best practices are necessary and beneficial in order ... According to research by benchmarking firm, Best Practices, ...
Breaking Medicine Technology:Perrigo Rejects Mylan Unsolicited Offer 2Perrigo Rejects Mylan Unsolicited Offer 3Perrigo Rejects Mylan Unsolicited Offer 4Researchers find alarming rise in cost of MS drugs over past two decades 2Researchers find alarming rise in cost of MS drugs over past two decades 3Researchers find alarming rise in cost of MS drugs over past two decades 4Work Around the Clock: Building Effective Global Capabilities 2
Cached News: