HOME >> MEDICINE >> NEWS
Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

ATLANTA-- Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition.

The hypothalamus serves as the central switching control for neural signals that regulate food intake and energy balance. Hormones such as insulin and leptin, which circulate in the blood plasma, are known to play an important role in regulating the brain's feeding signals, but scientists have not fully understand how these hormones interact with the brain circuitry. Neurotransmitters in the hypothalamus, including GABA (gamma aminobutyric acid), are known to be an important part of the pathway that regulates feeding behavior.

Scientists at Emory University School of Medicine had previously identified the Hap1 protein as crucial for the normal function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice failed to eat after birth. In addition, deleting Hap1 caused degeneration of some neurons in the hypothalamus.

In order to find out more about the function of Hap1 and the neural pathways it employs, a team of scientists from Emory, The Rockefeller University, the Burnham Institute for Medical Research, and the University of California, San Diego, conducted a series of experiments in mice. They found that fasting increased the level of Hap1 in the hypothalamus of the mice and that administering insulin decreased the Hap1 level. Suppressing Hap1 expression through RNA interference reduced mouse food intake and body weight. They also found that reducing Hap1 decreased t
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
9-Apr-2006


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
(Date:3/31/2015)... CA (PRWEB) March 31, 2015 Over ... robotic hair transplant technique have yielded better results ... , when refined and perfected by a good hair ... the most advanced techniques of hair restoration have improved ... can still be used to add precision and flexibility ...
(Date:3/31/2015)... In conjunction with the Asbestos ... the Mesothelioma Applied Research Foundation (Meso Foundation) announced ... complement its existing work in mesothelioma research, education, ... the Meso Foundation’s mission, we want to eliminate ... to asbestos, including mesothelioma,” said the Meso Foundation’s ...
(Date:3/31/2015)... Nashua, NH (PRWEB) March 31, 2015 ... Class of 2015 at Rivier University’s Commencement ... honorary doctorate of humane letters in recognition of her ... educator. , Serving as a front-line caregiver and senior ... for 25 years and advancing to leadership roles, including ...
(Date:3/31/2015)... Many people, including the ones with physical challenges, ... are only for able-bodied participants. , A new ... to change that thinking. , The program, part ... Sports Expo on Saturday, April 11 (10 a.m. to ... , The event will showcase a wide variety ...
(Date:3/31/2015)... 2015 OnChip Devices , a world ... silicon ESD diode chip targeted towards low voltage LED applications. ... Zeners are ideal for protecting circuits by suppressing voltage higher ... handle pulses of up to 350W and 20A, providing protection ... 61000-4-2 standard. These diodes do not exhibit any device ...
Breaking Medicine News(10 mins):Health News:Beverly Hills Hair Transplant Surgeon Now Combines Advanced Robotic Hair Transplantation and Manual Techniques for Greatest Results 2Health News:Mesothelioma Research Organization Announces New Prevention Program 2Health News:Mesothelioma Research Organization Announces New Prevention Program 3Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 3Health News:Memorial Healthcare System's Adaptive Sports Expo Encourages Physically Challenged To Go Beyond Perceived Limitations 2Health News:OnChip Introduces Low Voltage Diodes for High-Brightness LED Protection 2
(Date:3/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5r9f3t/eurpoean ... "Eurpoean Automatic External Defibrillators (AED) Market by Product ... Hospitals, Alternate Care Market, Home) - Forecast to ... The European automated external defibrillator (AED) market is ... from 2014 to 2019 ...
(Date:3/31/2015)... , March 31, 2015  The efficacy of continuous ... in a recently published study 1 of ultraviolet ... research team, including Curtis Donskey , M.D.  The ... for the same length of time from the same ... unit.  The results showed surprisingly low pathogen kill rates ...
(Date:3/31/2015)... RnRMarketResearch.com adds "Pemphigus - ... of 68 pages with latest updates, data and ... The report "Pemphigus - Pipeline Review, H1 2015" report ... for Pemphigus , complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ...
Breaking Medicine Technology:Eurpoean Automatic External Defibrillators (Semi-Automated, Fully-Automated) Market 2015-2019 - Pre-Hospitals, Public Access Market, Hospitals, Alternate Care Market, Home Analysis 2Eurpoean Automatic External Defibrillators (Semi-Automated, Fully-Automated) Market 2015-2019 - Pre-Hospitals, Public Access Market, Hospitals, Alternate Care Market, Home Analysis 3VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 2VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 3VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 4Pemphigus Therapeutic Development and Pipeline Review H1 2015 2Pemphigus Therapeutic Development and Pipeline Review H1 2015 3Pemphigus Therapeutic Development and Pipeline Review H1 2015 4
Cached News: