HOME >> MEDICINE >> NEWS
Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

ATLANTA-- Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition.

The hypothalamus serves as the central switching control for neural signals that regulate food intake and energy balance. Hormones such as insulin and leptin, which circulate in the blood plasma, are known to play an important role in regulating the brain's feeding signals, but scientists have not fully understand how these hormones interact with the brain circuitry. Neurotransmitters in the hypothalamus, including GABA (gamma aminobutyric acid), are known to be an important part of the pathway that regulates feeding behavior.

Scientists at Emory University School of Medicine had previously identified the Hap1 protein as crucial for the normal function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice failed to eat after birth. In addition, deleting Hap1 caused degeneration of some neurons in the hypothalamus.

In order to find out more about the function of Hap1 and the neural pathways it employs, a team of scientists from Emory, The Rockefeller University, the Burnham Institute for Medical Research, and the University of California, San Diego, conducted a series of experiments in mice. They found that fasting increased the level of Hap1 in the hypothalamus of the mice and that administering insulin decreased the Hap1 level. Suppressing Hap1 expression through RNA interference reduced mouse food intake and body weight. They also found that reducing Hap1 decreased t
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
9-Apr-2006


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
(Date:12/22/2014)... Angeles, CA (PRWEB) December 22, 2014 ... reputable PALS, BLS and ACLS online certification provider, are ... http://www.acls-pals-bls.com . The updated site now features a ... easier than ever to use. , As a ... peoples’ information is now consolidated into a single page ...
(Date:12/22/2014)... U.S. and state health officials are investigating a listeria ... least four people and sickened 28 others in 10 ... prepackaged caramel apples until more information becomes available, the ... a news release. As of Dec. 18, a ... outbreak strains of the bacteria Listeria monocytogenes . ...
(Date:12/22/2014)... 22, 2014 Super Saturday, the last ... year as the busiest day in the 2014 holiday ... Grass Station had a steady pre-Christmas stream of customers, ... past Saturday. , “I definitely intend to take advantage…of ... Denver resident who was enjoying The Grass Station’s holiday ...
(Date:12/22/2014)... recognition of Veteran’s Day, Discount Labels contributed a portion ... that provides services to veterans and their families, free ... hundred acres in the hills of Southern Indiana, the ... hiking, horseback riding, 4-wheeling, skeet shooting, and much more. ... U.S. Service men and women, police officers, fire fighters ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 7,178 small ... bustle of Black Friday shopping and opted instead to ... marketing education company, for their 5th annual “Black Friday ... charged just $7 to attend the 5 hour online ... they promptly donated to support two Central Texas based ...
Breaking Medicine News(10 mins):Health News:ACLS Online Certification Website ACLS-PALS-BLS.com Now Features a New and User-Friendly Layout 2Health News:CDC Warns of Listeria Danger From Caramel Apples 2Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3
(Date:12/22/2014)... Pa. and STOCKHOLM , ... (publ) (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced ... (CHMP) of the European Medicines Agency (EMA) has adopted ... clostridium histolyticum) for the treatment of adult men with ... of at least 30 degrees at the start of ...
(Date:12/22/2014)... Calif. , Dec, 22, 2014  Eiger ... Phase 2a study of lonafarnib in patients with ... was conducted at the National Institutes of Health ... .  The double-blinded, randomized, placebo-controlled, dose ascending ... twice daily and 200 mg twice daily for ...
(Date:12/22/2014)... 22, 2014 TWi Biotechnology, Inc., today ... for AC-201, TWi Biotechnology,s lead drug candidate, from ... China for patent application numbered 201180018154.8.  ... salts, active metabolite for treatment of type II ... treatment using AC-201 for type II diabetes, and ...
Breaking Medicine Technology:Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 2TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 3
Cached News: