HOME >> MEDICINE >> NEWS
Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

ATLANTA-- Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition.

The hypothalamus serves as the central switching control for neural signals that regulate food intake and energy balance. Hormones such as insulin and leptin, which circulate in the blood plasma, are known to play an important role in regulating the brain's feeding signals, but scientists have not fully understand how these hormones interact with the brain circuitry. Neurotransmitters in the hypothalamus, including GABA (gamma aminobutyric acid), are known to be an important part of the pathway that regulates feeding behavior.

Scientists at Emory University School of Medicine had previously identified the Hap1 protein as crucial for the normal function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice failed to eat after birth. In addition, deleting Hap1 caused degeneration of some neurons in the hypothalamus.

In order to find out more about the function of Hap1 and the neural pathways it employs, a team of scientists from Emory, The Rockefeller University, the Burnham Institute for Medical Research, and the University of California, San Diego, conducted a series of experiments in mice. They found that fasting increased the level of Hap1 in the hypothalamus of the mice and that administering insulin decreased the Hap1 level. Suppressing Hap1 expression through RNA interference reduced mouse food intake and body weight. They also found that reducing Hap1 decreased t
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
9-Apr-2006


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
(Date:3/5/2015)... 05, 2015 Hoggan Scientific, ... ergoFET physical therapy, ergonomic force gauges, and ... ergonomics, engineering, and research applications, introduced ... available at http://www.HogganHealth.net . The new ... healthcare professionals a handgrip muscle strength testing ...
(Date:3/5/2015)... (PRWEB) March 05, 2015 Elandas announces ... product innovations as the company prepares to announce its ... comprised of individuals in the Life Sciences field. , ... our clients,” said Elandas CEO Ryan Roberts. “We have ... successful organization through our collaborative efforts. As we continue ...
(Date:3/4/2015)... UK (PRWEB) March 05, 2015 ... clinical therapeutics landscape over the past decade. The ... carriers for drug delivery in the form of ... delivering manifold drugs with more safety and efficiency. ... nanoparticles could perhaps rely greatly upon the enhanced ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Ultraman Florida ... 6.2 mile swim, 261.4 mile bike, and 52.4 mile ... total time of 24:45:45. , "This race was awesome ... my wonderful team and sponsors for supporting me through ... Florida 2015 had a total of 40 select participants ...
(Date:3/4/2015)... TROY Healthcare Solutions will be introducing TROY ... level of security for prescriptions, in Houston, Texas on ... Center located at 6633 Travis Street from 7 AM ... TROY Healthcare Solutions will host a continental breakfast. Starting ... presentations each hour to introduce attendees to TROY Secure ...
Breaking Medicine News(10 mins):Health News:New Handgrip Strength Tester Receives Rave Reviews At Physical Therapy Conference 2Health News:Elandas Creates Advisory Board to Help Guide Innovation 2Health News:Cancer Nanomedicine Marketplace Discussed by Kuick Research in Topical Study Recently Published at MarketPublishers.com 2Health News:Cancer Nanomedicine Marketplace Discussed by Kuick Research in Topical Study Recently Published at MarketPublishers.com 3Health News:Living Fuel Champion Christian Isakson Finishes Second In UltraMan Florida Test of Endurance 2Health News:TROY Healthcare to Offer Prescription Solutions that can save a Hospital $100,000 2Health News:TROY Healthcare to Offer Prescription Solutions that can save a Hospital $100,000 3
(Date:3/4/2015)... MENLO PARK, Calif. , March 4, 2015 /PRNewswire/ ... biotechnology company in the emerging field of regenerative medicine, ... Chief Executive Officer, will ring The Opening Bell ® ... Thursday, March 5, 2015. Asterias began trading as an ... "New York Stock Exchange is a trusted ...
(Date:3/4/2015)...  NxStage Medical, Inc. (Nasdaq: NXTM ), a ... Jeffrey H. Burbank , Chief Executive Officer, will present at ... FL on Wednesday, March 11 th at ... will be made available at http://ir.nxstage.com  at the ... NxStage Medical, Inc. (Nasdaq: NXTM ) is ...
(Date:3/4/2015)...  Mail-service and specialty pharmacies will save ... health plans $11.8 billion over the next decade, ... Management Association (PCMA). "Home delivery of ... easiest ways to reduce health costs," said PCMA ... should resist efforts to restrict these cost-saving tools." ...
Breaking Medicine Technology:Asterias Biotherapeutics to Ring Opening Bell at New York Stock Exchange 2Asterias Biotherapeutics to Ring Opening Bell at New York Stock Exchange 3NxStage to Present at the Barclays Capital Global Healthcare Conference 2PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Illinois Employers, Consumers and Public Programs by $11.8 Billion 2
Cached News: