HOME >> MEDICINE >> NEWS
Head and neck cancer vaccine targets proteins to create immune response

LOS ANGELES, April 17 Most attempts to create therapeutic cancer vaccines are based on custom-made approaches that use a patient's own tumor cells to generate a strong immune response against cancer. However, developing these kinds of personalized vaccines is time-consuming, expensive and often impractical. Using an alternative approach, researchers at the University of Pittsburgh Cancer Institute (UPCI) in collaboration with the Gunma University School of Medicine in Japan, have developed a vaccine strategy for head and neck cancer that targets multiple peptides (parts of proteins) to activate the immune system to attack tumors. Their findings, abstract number 5113, will be included in a press briefing on cancer vaccines at the annual meeting of the American Association for Cancer Research, April 14-18, at the Los Angeles Convention Center.

The researchers created the vaccine to target a tumor suppressor gene called p53, which is mutated in most cancers and associated with poor clinical outcomes. Previous research has determined that mutated p53 also expresses unaltered, or "wild-type," p53 peptides in tumors. When presented on dendritic cells, these wild-type p53 peptides may induce an immune response to strengthen the body's natural defenses against cancer and decrease the chance of cancer recurrence and the formation of secondary tumors.

"The key to our strategy is to select those p53 peptides that can best activate the immune system and induce it to produce immune cells able to recognize and eliminate the tumor," said Theresa Whiteside, Ph.D., who in collaboration with Albert DeLeo, Ph.D., directed the study. Both investigators are professors of pathology and immunology at the University of Pittsburgh School of Medicine. "Through animal models and human cells in culture, we have found that this strategy is very effective at stimulating T cells into action," said Dr. Whiteside, who also directs UPCI's Immunologic Monitoring and Cellula
'"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
17-Apr-2007


Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. Stomach cancer rate set to fall further 25 percent over next decade
4. MRI finds breast cancer before it becomes dangerous
5. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
6. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
7. Pathway links inflammation, angiogenesis and breast cancer
8. Using MRI for diagnosis could help prevent breast cancer progression
9. Electric fields have potential as a cancer treatment
10. Shining light on pancreatic cancer
11. Method shows promise for early detection of pancreatic cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... ... October 08, 2019 , ... PotentiaMetrics, an ... Jerry Henderson as Chief Medical Officer. Dr. Henderson will be responsible for the ... Dr. Henderson previously served as Chair of both the Informatics Governance and the ...
(Date:10/8/2019)... MARINA DEL REY, Calif. (PRWEB) , ... October ... ... Quality Confab for laboratory managers, administrators and pathologists, 4medica® President ... Perfect Payment™ is the first-to-market solution reinventing labs orders management-by starting with ...
(Date:10/8/2019)... ... October 08, 2019 , ... Smile Brands Inc. has been named one ... Comparably. Smile Brands, a leading dental support organization with nearly 440 affiliated practices across ... Smiles for Everyone®. The Happiness Award is the latest in a series of ...
(Date:10/8/2019)... ... 2019 , ... EBSCO Information Services ( EBSCO ) has ... from Dynamic Health™ into the MCN platform. Dynamic Health is EBSCO's ... MCN provides custom policy content, document management software and compliance expertise to healthcare ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... On November 9, 2019, husband and wife ... No Cost Dental Day . 2019 marks the ninth consecutive year that Mansouri ... community who are in need. , This event has always had a great turnout, serving ...
Breaking Medicine News(10 mins):
(Date:10/15/2019)... FORESIDE, Maine (PRWEB) , ... ... ... Standards1 releases VALIDATE® LP2 linearity and calibration verification kit, for Roche cobas® ... A (Apo-A1) and Apolipoprotein B (Apo-B). Each VALIDATE® LP2 kit, liquid, ...
(Date:10/11/2019)... ... October 11, 2019 , ... Five New York fitness studios have teamed up to create ... opportunity to tour and sample a variety of the top group exercise classes offered on ... produced by Club Pilates on W. 57th St., the Hell’s Kitchen Sweat Crawl will feature ...
(Date:10/10/2019)... ... October 10, 2019 , ... Ovation Fertility is once ... of reproductive medicine, with six abstracts accepted for poster presentations at the ASRM ... October 12-16, 2019, in Philadelphia. , “Ovation will have a prominent presence in ...
Breaking Medicine Technology:
Cached News: