Despite a decline in the annual death rate from carbon monoxide (CO) poisoning, CO remains the most common type of accidental poisoning in the United Sates, contributing to 40,000 emergency department visits each year, according to background information. The Centers for Disease Control and Prevention reported that from 1968 through 1998 CO poisoning contributed to an average of 1,091 unintentional deaths and 2,385 suicidal deaths in the U.S. annually. Symptoms of CO poisoning include weakness, nausea, dizziness, lethargy, confusion and headache. In addition to neurological effects, heart damage has also often been reported in CO poisoning cases.
Christopher R. Henry, B.S., of the Minneapolis Heart Institute Foundation, and colleagues studied 230 patients treated for moderate to severe CO poisoning to evaluate the association between the patients' heart damage following CO poisoning and long-term risk of death. Patients admitted to the Hennepin County Medical Center between January 1, 1994, and January 1, 2002, were included in the study, with follow-up conducted through November 11, 2005. Heart muscle damage was characterized by elevated levels of cardiac troponin I (type of protein) or creatine kinase-MB (type of enzyme), and/or changes in diagnostic electrocardiogram (ECG).
Heart muscle injury occurred in 85 (37 percent) of the 230 patients with CO poisoning. At a mid-point follow-up of 7.6 years (ranging up to 11.8 years), 54 deaths had occurred (24 percent), with 12 (five percent) of those deaths taking place in the hospital. Of the 85 patients with heart damage, 32 (38 percent) died during fol
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Contact: Steven Linders
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JAMA and Archives Journals
24-Jan-2006