HOME >> MEDICINE >> NEWS
Heparin antibodies may pose risk in heart surgery patients

WINSTON-SALEM, N.C. New research suggests that patients who develop antibodies to the anti-clotting drug heparin nearly double their risk of death or serious complication after heart surgery.

"Complications after heart surgery are typically attributed to the surgery alone," said Thomas Slaughter, M.D., co-principal investigator on the project and a professor of anesthesiology at Wake Forest University Baptist Medical Center. "Our study examined whether development of heparin antibodies before surgery poses an independent risk."

The study, which involved 466 patients scheduled to undergo either coronary artery bypass or valve replacement surgery, is reported in this month's Journal of Thoracic and Cardiovascular Surgery. Conducted by investigators at Wake Forest University Baptist and Duke University medical centers, it is the first study to convincingly demonstrate a relationship between heparin antibodies and complications after cardiac surgery.

Heparin is administered intravenously during many procedures, including kidney dialysis, heart catheterization or angioplasty, as well as during heart and vascular surgeries. Estimates suggest that nearly half of patients treated with heparin develop the antibodies, which may last for months.

The researchers theorize that in patients with heparin antibodies, subsequent treatment with heparin activates blood components that cause clotting and inflammation, increasing the risk for heart attacks, heart rhythm problems, strokes and other complications.

"While it is too early to recommend universal testing for the antibodies, our study is the most definitive evidence to date that heparin antibodies increase the risk for death and complications associated with cardiac surgery," said Slaughter.

The researchers tested heparin antibody levels in all study patients before surgery. They found that patients with the antibodies experienced a nearly twofold greater risk of death or hospi
'"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
2-Dec-2005


Page: 1 2

Related medicine news :

1. Human antibodies protect mice from avian flu
2. Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
3. Magnesium loss in patients given monoclonal antibodies
4. Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies
5. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
6. Polymorphism and antibodies associated with highly increased risk of rheumatoid arthritis
7. Jefferson and Delaware researchers combine tiny nanotubes and antibodies to detect cancer
8. Jefferson scientists create plant factories churning out antibodies against tumor cells
9. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
10. Drug for cluster headaches may cause heart problems
11. Reductive stress linked to heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... ... to build intelligent, connected applications, was named the best Sales Team of 2016 ... winner announcement was made today by the Software & Information Industry Association (SIIA), ...
(Date:11/30/2016)... ... November 30, 2016 , ... The Fertility Centers of ... a Cigna Infertility Center of Excellence. The Cigna Center of Excellence recognizes participating ... honor to be designated a Cigna Infertility Center of Excellence," said Fertility Centers ...
(Date:11/30/2016)... ... November 30, 2016 , ... Standard Process, Inc. ... annual ranking and recognition of the largest closely held companies headquartered in Wisconsin. ... 2008-2016. In addition, Standard Process was awarded the Talent Award for providing outstanding ...
(Date:11/30/2016)... MA (PRWEB) , ... November 30, 2016 , ... ... for treating injured workers have been a focus of public policymakers and system ... Compensation Research Institute (WCRI) released its Medical Price Index for Workers’ Compensation, ...
(Date:11/30/2016)... ... November 30, 2016 , ... The Valley’s leading orthopedic practice, ... of new North Phoenix and Chandler locations. , The new North Phoenix location ... 9327 North 3rd St, Suite 300 in Phoenix. The practice’s new Chandler location ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... North America held the largest share in the ... aged population and demand for remote monitoring ECG devices. On ... region is expected to witness the highest growth rate during ... Company (U.S.), Becton, Dickinson and Company (U.S.), Medtronic plc ( ... Netherlands ) and Mindray Medical International Limited ( ...
(Date:12/2/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... , , The global ultrasound ... is expected to grow at a CAGR of 5.5% during 2016-2022. Based ... during the forecast period, a CAGR of 8.8% in the global market. ...
(Date:12/2/2016)... FRANCISCO , Dec. 2, 2016  PipelineRx, a ... telepharmacy, will be offering demonstrations of its SaaS-based ... Society of Health-System Pharmacists 2016 Midyear Clinical Meeting ... Vegas . With nearly 300 hospital clients ... services and technology designed to dramatically improve pharmacy ...
Breaking Medicine Technology:
Cached News: