HOME >> MEDICINE >> NEWS
Heparin antibodies may pose risk in heart surgery patients

WINSTON-SALEM, N.C. New research suggests that patients who develop antibodies to the anti-clotting drug heparin nearly double their risk of death or serious complication after heart surgery.

"Complications after heart surgery are typically attributed to the surgery alone," said Thomas Slaughter, M.D., co-principal investigator on the project and a professor of anesthesiology at Wake Forest University Baptist Medical Center. "Our study examined whether development of heparin antibodies before surgery poses an independent risk."

The study, which involved 466 patients scheduled to undergo either coronary artery bypass or valve replacement surgery, is reported in this month's Journal of Thoracic and Cardiovascular Surgery. Conducted by investigators at Wake Forest University Baptist and Duke University medical centers, it is the first study to convincingly demonstrate a relationship between heparin antibodies and complications after cardiac surgery.

Heparin is administered intravenously during many procedures, including kidney dialysis, heart catheterization or angioplasty, as well as during heart and vascular surgeries. Estimates suggest that nearly half of patients treated with heparin develop the antibodies, which may last for months.

The researchers theorize that in patients with heparin antibodies, subsequent treatment with heparin activates blood components that cause clotting and inflammation, increasing the risk for heart attacks, heart rhythm problems, strokes and other complications.

"While it is too early to recommend universal testing for the antibodies, our study is the most definitive evidence to date that heparin antibodies increase the risk for death and complications associated with cardiac surgery," said Slaughter.

The researchers tested heparin antibody levels in all study patients before surgery. They found that patients with the antibodies experienced a nearly twofold greater risk of death or hospi
'"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
2-Dec-2005


Page: 1 2

Related medicine news :

1. Human antibodies protect mice from avian flu
2. Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
3. Magnesium loss in patients given monoclonal antibodies
4. Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies
5. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
6. Polymorphism and antibodies associated with highly increased risk of rheumatoid arthritis
7. Jefferson and Delaware researchers combine tiny nanotubes and antibodies to detect cancer
8. Jefferson scientists create plant factories churning out antibodies against tumor cells
9. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
10. Drug for cluster headaches may cause heart problems
11. Reductive stress linked to heart disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heparin antibodies may pose risk heart surgery patients

(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... One of ... interviews to discuss his new book, The Pain Antidote , which provides strategies ... of Las Vegas Recovery Center’s Chronic Pain Treatment Program, wrote the book in conjunction ...
(Date:8/4/2015)... ... 04, 2015 , ... 24/7 Care At Home , a provider of ... today announced that the U.S. Department of Veteran’s Affairs (VA) has awarded its agency ... is well on the path to meeting the aspirational goals the VA promotes each ...
(Date:8/4/2015)... ... 04, 2015 , ... Increasingly, patients are researching online to ... In an effort to share more and better information with these savvy and ... share patient satisfaction ratings and comments about its doctors and advanced practice providers. ...
(Date:8/4/2015)... ... August 04, 2015 , ... SanusEO, the healthcare industry ... its executive leadership team as Senior Vice President of Sales and Marketing. Mr. ... expanding global markets with a special emphasis on the healthcare industry. , Today, ...
(Date:8/4/2015)... NJ (PRWEB) , ... August 04, 2015 , ... Montclair ... Arts and Health, the first of its kind in New Jersey, which starting this ... of the Arts and Graduate School partnered with Atlantic Health System, one of the ...
Breaking Medicine News(10 mins):Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 2Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 3Health News:24/7 Care At Home Receives Two Stars from the VA 2Health News:24/7 Care At Home Receives Two Stars from the VA 3Health News:UPMC 1st in Pa. to Share Provider Ratings 2Health News:UPMC 1st in Pa. to Share Provider Ratings 3Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 2Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 3
(Date:8/4/2015)... Young Innovations ("Young"), a leading global ... the acquisition of the professional dental contract manufacturing ... MPL PDCMD manufactures fluoride varnish, prophy paste and ... procedures. "This acquisition marks the ... high-growth segments," said Dave Sproat , CEO ...
(Date:8/4/2015)... , Aug. 4, 2015  Rigel Pharmaceuticals, Inc. (Nasdaq: ... second quarter and six months ended June 30, 2015. ... in ITP are progressing and we continue to expect ... Rodriguez , president and chief executive officer of Rigel. ... other clinical programs, including evaluating fostamatinib for new treatment ...
(Date:8/4/2015)... SEATTLE , Aug. 4, 2015  Dr. ... Institute states the potential FDA approval of flibanserin, ... sets women and the treatment of decreased female ... women has many root causes and addressing libido ... is dangerous. ...
Breaking Medicine Technology:Young Innovations Announces Acquisition of Medical Products Laboratories' Professional Dental Contract Manufacturing Division 2Rigel Announces Second Quarter 2015 Financial Results 2Rigel Announces Second Quarter 2015 Financial Results 3Rigel Announces Second Quarter 2015 Financial Results 4Rigel Announces Second Quarter 2015 Financial Results 5Rigel Announces Second Quarter 2015 Financial Results 6Potential FDA Approval of "Pink Viagra" Sends Wrong Message 2Potential FDA Approval of "Pink Viagra" Sends Wrong Message 3Potential FDA Approval of "Pink Viagra" Sends Wrong Message 4Potential FDA Approval of "Pink Viagra" Sends Wrong Message 5
Cached News: