Hepatitis C drug proves cost-effective in helping patients with treatment-indu...( FINDINGS: A UCLA/VA study found that ...),Health

IMPACT: The study may lead to a new treatment standard for the one-third of Hepatitis C patients who develop treatment-induced anemia as a result of taking a key medication called ribarvirin. Over 4 million Americans are infected with Hepatitis C.

AUTHORS: Dr. Brennan M.R. Spiegel, director, UCLA/VA Center for Outcomes Research and Education (CORE) and assistant professor of medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, is available for interviews.

JOURNAL: The research will appear in the Oct. 1 edition of the peer reviewed Clinical Gastroenterology and Hepatology. A PDF of the full study is available.

FUNDING: Spiegel is supported with funding by a VA HSR&D Research Career Development Award. The research was also funded by Amgen Inc. Global Health Outcomes. Dr. Spiegel has received research funding from Amgen and has served as a consultant.

BACKGROUND: Ribarvin, a common medication used in treating Hepatitis C, can cause anemia, which traditionally leads to dosage reduction and diminished treatment compliance by patients. Practice guidelines suggest that patients with anemia receive a drug called erythropoietin, which helps prevent treatment-induced anemia by increasing the number of red blood cells in the body. Erythropoietin has been proven to help patients maintain a full dose therapy of ribarvin, thus improving rates of complete cure from Hepatitis C. However, the drug is expensive, so it is unclear whether its benefits outweigh its cost.

UCLA researchers conducted a cost-effectiveness analysis and found that despite the high c
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Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-0777
University of California - Los Angeles
3-Oct-2005