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Hepatitis C increases risk of non-Hodgkin lymphoma

ype Waldenstrm macroglobulinemia in persons with HCV infection," the authors report. Low-grade lymphoma tends to grow and spread slowly.

HCV infection was also associated with an increased risk of nonmalignant plasma cell disorders.

"We demonstrated that infection precedes development of these outcomes, and that the risk in individuals infected with HCV is consistently increased, with over five years of follow-up," the authors continue.

The study found no significantly increased risk for other hematological malignancies. The risk for thyroid cancer was not increased.

"Although the clinical significance of these findings is unknown, it is possible that screening of individuals infected with HCV could identify early stage lymphoproliferative conditions suitable for early intervention strategies, including chemoprevention trials on premalignant disease. Future epidemiological and pathophysiological studies are needed to further explore the relationship between HCV and NHL," the authors conclude.


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Contact: Kimberlee Barbour
713-798-7971
JAMA and Archives Journals
8-May-2007


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