HOME >> MEDICINE >> NEWS
Hepatitis C recurs rapidly after liver transplant

When a diseased liver is removed from a patient with Hepatitis C (HCV), serum viral levels plummet. However, after receiving a healthy liver transplant, virus levels rebound and can surpass pre-transplant levels within a few days, according to a new study published in the February 2006 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience (http://www.interscience.wiley.com/journal/livertransplantation).

Hepatitis C is the number one reason for liver transplantation, however, the virus always recurs in the new liver. Since mathematical models have been useful in the study of the viral dynamics of HIV and hepatitis B, researchers, led by Kimberly A. Powers and Ruy M. Ribeiro of the Los Alamos National Laboratory in New Mexico, sought to use a mathematical model to quantify the liver reinfection dynamics of HCV.

The researchers, in collaboration with a surgical team lead by John McHutchison now at Duke University Medical Center, followed six HCV-infected patients who received cadaveric liver transplants. They collected blood samples before, during and after transplantation to assess changing levels of HCV RNA which was measured using reverse transcription polymerase chain reaction assay. They then plugged the data into a mathematical model, correcting for fluid balance, and analyzed the results using linear regression.

"In most patients," the authors report, "HCV RNA levels decreased rapidly during and after transplantation and subsequently began to increase reaching above pre-transplant levels in all but one patient within a few days of the procedure." They found that when the diseased liver was removed, virus level
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
2-Feb-2006


Page: 1 2

Related medicine news :

1. Hepatitis C negatively impacts HIV
2. Hepatitis B patients understanding of infection and treatment deficient
3. Hepatitis C increases risk of non-Hodgkin lymphoma
4. HIV/Hepatitis information service through the Internet
5. Liver transplants can be successful in HIV patients with Hepatitis B
6. NDRI researchers evaluate prison Hepatitis program
7. Scientists call for Hepatitis treatment of young injection drug users
8. Preventive treatment helps avoid Hepatitis B relapse during chemotherapy
9. Patients with Hepatitis C using more healthcare resources
10. Interferon with ribavirin is safe and effective for children with chronic Hepatitis C
11. Hepatitis C drug proves cost-effective in helping patients with treatment-induced anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... ... ... Robert E. Burke, MD, PhD, had a successful career as a pediatrician and ... have led him down a much different path. , In his book, “Beyond the ... Dr. Burke shares a personal account of the tribulations he encountered on his path ...
(Date:2/27/2017)... ... February 27, 2017 , ... The threat of nuclear warfare has long plagued ... involved in the underground testing of nuclear weapons. Years later, when her co-workers began ... the Cold War Nuclear Testing,” Clayton exposes the critical decisions made by agencies involved ...
(Date:2/27/2017)... ... February 27, 2017 , ... This webinar ... analysis as a tool to characterize particle size distributions in the field of ... results and novel scientific findings. It describes methods of optimized and standardized sample ...
(Date:2/27/2017)... ... February 27, 2017 , ... Texas based retail electric company ... Power's RCE (Residential Customer Equivalent) count exceeds 150,000. , Discount Power ... customers and 2,250 RCEs at the time of acquisition. In the three years ...
(Date:2/27/2017)... San Francisco, CA (PRWEB) , ... February 27, ... ... transplant clinic serving San Francisco and environs, is proud to announce an upgrade ... research information on the upgraded Yelp page on topics as diverse as Platelet ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017   Vitasome ® ... of nutritional supplements using its groundbreaking new liposome technology. ... percent of potency through digestion per Physician,s Desk ... solve the problem of nutritional waste and are scientifically ... during digestive processes Improve bioavailability with ...
(Date:2/27/2017)... A recent research report published by Grand ... is expected to reach a value of $55.8 billion by 2025. ... 28 states have legalized marijuana for medical uses. In 2016, states ... , North Dakota , Ohio ... the drug in medical applications such as chemotherapies and pain management. ...
(Date:2/27/2017)... The Hague, The Netherlands , Feb 27, 2017 /PRNewswire/ ... Sectra Tiger/R is approved by NATO for use at ... requirements on security imposed within the NATO organization for the ... ... aimed at providing government authorities with an eavesdrop-secure smartphone solution. ...
Breaking Medicine Technology:
Cached News: