HOME >> MEDICINE >> NEWS
High levels of immunosuppressant may lead to tumor recurrence

A new study on the incidence of liver cancer after transplant found that high levels of the immunosuppressant cyclosporine favored tumor recurrence and identified blood levels of the drug that should not be exceeded. Lower levels of cyclosporine levels did not affect rejection rates.

The results of this study appear in the May 2005 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/livertransplantation.

Hepatocellular carcinoma (HCC, a type of liver cancer) occurs frequently in patients with chronic liver disease who are listed for liver transplants. However, the immunosuppressants necessary to prevent rejection can accelerate tumor growth, and the incidence of tumor recurrence is high.

Because of this, strict selection criteria of patients with HCC has limited their access to transplants, yet the role of immunosuprressants in tumor growth has not been well established. In a previous study, the authors demonstrated a close relationship between the amount of cyclosporine and tumor recurrence in liver transplant patients.

The current study further examines this association and identifies possible strategies to avoid it.

Led by Marco Vivarelli of the department of surgery and transplantation at the University of Bologna, Italy, the study examined 70 patients who took cyclosporine as the main immunosuppressant following liver transplants between 1991 and 2002. The cyclosporine dosage was determined by the clinician in charge based on clinical and biochemical indications, but without regard to blood levels achieved by the drug after it was administered. HCC
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
22-Apr-2005


Page: 1 2

Related medicine news :

1. Even low levels of weekly exercise drive down blood pressure
2. Low hospital staff levels increase infection rates
3. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
4. Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
5. Exercise may slightly boost good cholesterol levels
6. Coffee consumption may lower blood uric acid levels -- the precursor of gout
7. Different type of iron supplement is better at boosting iron levels
8. Yoga and elevated brain GABA levels
9. Statin use linked with decreased prostate cancer mortality rates, lower PSA levels
10. Low physical activity can improve fitness levels for sedentary, overweight postmenopausal women
11. Neglected epidemic of chronic lung disease; childhood conditions affect adult progesterone levels

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... 2020 , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), ... University (CMU) to develop a new heart monitoring device designed to serve as ... The AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic ... announced today the launch of its integrated, HIPAA compliant, telehealth solution, available to ... practice in under 90 seconds. , According to the U.S. Department of ...
(Date:8/31/2020)... ... 31, 2020 , ... In an effort to give back to the community ... of each hotel room booked with a special new rate code to benefit children ... , effective immediately. Donations will be applied to any room type, any time, ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ is a ... respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ventilators. It ... gas and scrubs it free of carbon dioxide in a completely closed “rebreather” ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... that strongly suggest that obese individuals are at an increased risk of developing ... more likely to catch COVID-19; however, because the same organ systems that the ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Breast and ovarian cancers ... Control (CDC), About 3% of breast cancers (about 7,500 women per year) and 10% ... BRCA1 and BRCA2 genes. Both genes are detectable in the Women’s Excellence Genetic ...
(Date:8/31/2020)... SEATTLE (PRWEB) , ... August 31, 2020 , ... ... technology research and advisory guide, has named Cloudticity a Gold winner in the ... are industry and peer recogniti o ns from Network Products Guide ...
(Date:8/27/2020)... , ... August 27, 2020 , ... Austin Oral Surgery ... is pleased to announce Dr. David Szalay, DDS, MD, has joined the practice. An ... in the new Pflugerville office, which is scheduled to open this fall. The new ...
Breaking Medicine Technology:
Cached News: