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High tech imaging tells the tale of plaque from the inside out

Not all plaque the fatty substance that builds up in arteries is the same and some plaque types are more likely to rupture, which can trigger the formation of a blood clot and a blocked artery. An experimental spectroscopic/imaging technique can provide exact information about plaque components that can help guide treatment, researchers reported at the American Heart Association's Scientific Sessions 2005.

"Time-resolved laser-induced fluorescence spectroscopy or TR-LIFS can be used to accurately identify plaque with these dangerous characteristics, while the plaque still lines the walls of vessels," said lead researcher Laura Marcu, Ph.D., director of biophotonics research at the Cedars-Sinai Medical Center and associate professor at the University of Southern California in Los Angeles.

The laser pulse heats up or "excites" molecules in the plaque while researchers measure the "time" that molecules stay in the excited state. This time is specific to different types of molecules, which helps researchers determine the "exact composition of the plaque."

When plaque has a thin, fibrous layer or cap over a large core area of lipids, it's most vulnerable to rupture, which can result in the blood supply to a part of the heart or brain being blocked.

Researchers tested the TR-LIFS device by identifying the type of plaque found in the carotid arteries, the main blood supply for the brain. They measured 353 plaque areas in the carotid arteries of 50 patients who were scheduled to undergo carotid endarterectomy, a procedure in which the carotid arteries are opened and plaque is surgically removed.

After the endarterectomy was done, pathologic examination was used to categorize the plaques as early (minimal thickening), fibrotic (collagen-rich lesions), or high-risk (necrotic core with a thin cap). These results were compared to those the researchers received when using the fluorescence spectroscopy to categorize the same plaques as early, fibro
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Contact: Carole Bullock or Karen Astle
carole.bullock@heart.org
214-706-1396
American Heart Association
15-Nov-2005


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