HOME >> MEDICINE >> NEWS
Higher levels of cells originating in bone marrow may be useful in prognosis of liver cancer

culture blood cells and count the number of colonies (colony formation units or CFU) formed by endothelial cells. This enabled them to differentiate EPCs that originated in the bone marrow from endothelial cells that are found in normal tissues throughout the body. They also analyzed levels of vascular endothelial growth factor (VEGF) and interleukin-8 (IL8), two proteins that are thought to be involved in new blood vessel formation in tumors.

The results showed that the HCC patients had significantly higher CFU scores than the control patients, and that those with inoperable HCC had significantly higher CFU scores than those whose tumors could be treated surgically. "These findings could suggest a possible relationship between more aggressive tumor and higher circulating levels of EPCs," the authors state.

In addition, in the 17 patients who had surgery and were followed for at least one year, CFU scores prior to surgery were much higher in those who experienced recurrence within a year. Researchers also analyzed levels of alpha-fetoprotein (AFP), a specific biomarker of HCC, and found that patients with higher CFU scores had higher levels of AFP. Similarly, there was a correlation between both VEGF and IL8 levels and CFU scores. The authors note that "since both circulating levels of IL8 and VEGF have been reported to be highly associated with angiogenesis [new blood vessel formation] and prognosis of HCC, the finding in our study provides additional evidence for the possible role of EPCs in tumor angiogenesis."

"Taken together, our study suggests that EPCs may have a significant implication in HCC in terms of prognosis," the authors note. They suggest that further studies with more patients and longer follow-up times would be useful, as would further evaluations of known prognostic factors together with CFU and AFP levels. It would also be helpful to follow CFU scores over time in patients who undergo surgery for HCC to determine if
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
3-Oct-2006


Page: 1 2 3

Related medicine news :

1. Higher intake of fish and vitamin D levels linked to lower risk of age-related macular disease
2. Higher gas prices leave many workers running on empty
3. Higher calcium and vitamin D intakes positively associated with brain lesions in older men and women
4. Higher physical activity associated with reduced risk of breast cancer
5. Higher blood pressure associated with decline in walking ability in older persons
6. Higher levels of obesity associated with greater health risks
7. Higher death rates associated with increasing degrees of obesity, PITT researchers report
8. Higher strength MRI can help patients avoid arthroscopy for shoulder injuries
9. Higher self-awareness of memory complaints predict brain function decline
10. Higher rates of infection may explain why women have higher risk of death after bypass surgery
11. Higher optimism levels associated with lower risk of cardiovascular death in elderly men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 21, 2020 , ... In response to the Coronavirus pandemic, Industrial ... users to open swing-style doors without using their hands or fingertips. , ... door open using their forearm, wrist or elbow when entering or exiting a room. ...
(Date:5/21/2020)... ... May 21, 2020 , ... Fujirebio ... in cancer biomarker assays, announced today that Cigna has added ROMA® (Risk of ... global health service company dedicated to improving the health, well-being, and peace of ...
(Date:5/21/2020)... ... 21, 2020 , ... A Safe Haven Foundation (ASHF) has been selected as ... COVID-19 Community Resilience Fund. The fund was created in March to help nonprofits with ... in service to vulnerable populations in hard-hit communities. , “We are humbled and ...
(Date:5/21/2020)... ... May 21, 2020 , ... In response to Michigan Governor ... May 28th and all businesses will be required to have covid-19 employee screening, ... , As an essential business, AmeriCare Medical began this precautionary process in early ...
(Date:5/21/2020)... ... , ... The Rise of Mental Health and Substance Abuse During COVID-19, Entering ... needless to say, more complications. With rising deaths, more confirmed cases every day, and ... hard to escape and find peace. Adding to these persistent stressors are quarantine orders. ...
Breaking Medicine News(10 mins):
(Date:5/25/2020)... ... May 24, 2020 , ... May is National Electrical ... the public to know what safety resources are available. Every year during ... an education campaign to inform the public about safety steps that can reduce ...
(Date:5/21/2020)... ... May 21, 2020 , ... In today’s news cycle we often ... touch or shake hands with others; to avoid restaurants, movie theaters, concerts, sporting events ... your Netflix, AppleTV+, YoutubeTV or Prime Video subscriptions. But as things begin to return ...
(Date:5/21/2020)... ... May 21, 2020 , ... MedTech Breakthrough ... products in the global health and medical technology market, today announced that ... selected as the winner of its “Health Administration Innovation Award” in the fourth ...
Breaking Medicine Technology:
Cached News: