HOME >> MEDICINE >> NEWS
Higher placental weight associated with increased maternal breast cancer risk

n who had placentas weighing less than 500 g in 2 consecutive pregnancies, the risk of breast cancer was increased among women whose placentas weighed between 500 and 699 g in their first pregnancy and at least 700 g in their second pregnancy (or vice versa), and the corresponding risk was doubled among women whose placentas weighed at least 700 g in both pregnancies. A high birth weight (4000 g or greater) in 2 successive births was associated with an increased risk of breast cancer before but not after adjusting for placental weight and other covariates. Compared with women who had a placental weight of less than 500 g, women who had a placental weight of at least 700 g had a 38 percent increase in risk of breast cancer.

"Our finding of a positive association between placental weight and breast cancer risk may reflect that exposures to elevated levels of pregnancy hormones influence the risk of breast cancer. The role of estrogens in breast carcinogenesis is well established, and serum estrogen levels are at least 10 times higher during pregnancy compared with other times of life," the authors write.

"In addition, placental weight appears to be a better indicator of the hormonal milieu than birth weight or other included birth parameters. Underlying biological mechanisms responsible for the observed associations may not only be limited to a direct growth enhancing effect on breast cells during childbearing, but also may be due to maternal characteristics or genetic factors associated with placental growth," the researchers conclude. (JAMA.2005; 294:2474-2480. Available pre-embargo to the media at www.jamamedia.org)


'"/>

Contact: Sven Cnattingius, M.D., Ph.D.
sven.cnattingius@mep.ki.se
JAMA and Archives Journals
15-Nov-2005


Page: 1 2

Related medicine news :

1. Higher intake of fish and vitamin D levels linked to lower risk of age-related macular disease
2. Higher gas prices leave many workers running on empty
3. Higher calcium and vitamin D intakes positively associated with brain lesions in older men and women
4. Higher physical activity associated with reduced risk of breast cancer
5. Higher levels of cells originating in bone marrow may be useful in prognosis of liver cancer
6. Higher blood pressure associated with decline in walking ability in older persons
7. Higher levels of obesity associated with greater health risks
8. Higher death rates associated with increasing degrees of obesity, PITT researchers report
9. Higher strength MRI can help patients avoid arthroscopy for shoulder injuries
10. Higher self-awareness of memory complaints predict brain function decline
11. Higher rates of infection may explain why women have higher risk of death after bypass surgery

Post Your Comments:
(Date:5/28/2015)... 28, 2015 On Sunday, June 21, ... a team event to honor the strength, passion and ... summer solstice, the duration of this sunrise-to-sunset event symbolizes ... and their caregivers. Participants raise funds and awareness to ... Alzheimer’s Association. , Teams are encouraged to create their ...
(Date:5/28/2015)... The Boys & Girls Club of Atlantic ... Cross Blue Shield of New Jersey (Horizon BCBSNJ) and through ... can receive much more support as play begins for the ... Boys & Girls Club member and volunteer with the organization ... has accepted the Horizon Blue Cross Blue Shield of New ...
(Date:5/28/2015)... 2015 New Jersey Plastic Surgeon and ... world-class results. With over 30 years of experience ... in art, Dr. Rafizadeh knows what it takes to ... Plastic Surgery involves the principles of proportion, harmony and ... level of comfort and personalized care from the moment ...
(Date:5/28/2015)... May 28, 2015 Ross A. Clevens, ... , has hired Teresa Beard as the new marketing ... role, Beard will oversee all marketing and promotional events ... experience leading teams and developing compelling marketing strategies to ... Body Specialists, Beard served as guest communication manager at ...
(Date:5/28/2015)... The Paw Project, an international nonprofit ... to educate the Oregon public about the harmful consequences ... Market Street and Park Avenue in Salem, Oregon's state ... Cats, Raise Your Hand,” depicts a human hand with ... graphic and anatomically-correct representation of the declaw surgery performed ...
Breaking Medicine News(10 mins):Health News:Golf Pro Natalie Gulbis to Chip in with Horizon Blue Cross Blue Shield of New Jersey to Support Boys & Girls Club of Atlantic City 2Health News:Golf Pro Natalie Gulbis to Chip in with Horizon Blue Cross Blue Shield of New Jersey to Support Boys & Girls Club of Atlantic City 3Health News:"NJ Top Doc", Dr. Farhad Rafizadeh is Excited to Offer New Services at his Plastic Surgery Practice 2Health News:"NJ Top Doc", Dr. Farhad Rafizadeh is Excited to Offer New Services at his Plastic Surgery Practice 3Health News:Clevens Face and Body Specialists Welcomes Teresa Beard as Marketing Director 2Health News:Declawing is Cruel, Education is the Key - Says the Paw Project 2Health News:Declawing is Cruel, Education is the Key - Says the Paw Project 3
(Date:5/28/2015)... WARSAW, Ind. , May 28, 2015 ... today that it has finalized agreements with buyers to ... certain Zimmer® Unicompartmental High-Flex Knee System assets, Biomet Discovery® ... divestiture agreements are in furtherance of Zimmer,s pending acquisition ... Zimmer continues to work constructively with the ...
(Date:5/28/2015)... 28, 2015  Pharmaceutical companies and diagnostics ... tests, and this is translating into a ... assist them. This according to Kalorama Information, a ... such as mass spectrometry, electrophoresis and liquid ... of drug targets and the validation of ...
(Date:5/28/2015)... , May 28, 2015  Maetrics ( http://maetrics.com ), ... sciences sector, wrapped up a successful conference, "The cost ... Technology industry," today in Zurich . ... ) and its Switzerland -based team, ... the Medical Technology field to an exclusive local audience. ...
Breaking Medicine Technology:Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6Report: Proteomics Research Market Reaches $1.6 Billion 2Report: Proteomics Research Market Reaches $1.6 Billion 3Maetrics Hosts Innovative Medical Cluster Event in Switzerland 2
Cached News: