HOME >> MEDICINE >> NEWS
Higher placental weight associated with increased maternal breast cancer risk

n who had placentas weighing less than 500 g in 2 consecutive pregnancies, the risk of breast cancer was increased among women whose placentas weighed between 500 and 699 g in their first pregnancy and at least 700 g in their second pregnancy (or vice versa), and the corresponding risk was doubled among women whose placentas weighed at least 700 g in both pregnancies. A high birth weight (4000 g or greater) in 2 successive births was associated with an increased risk of breast cancer before but not after adjusting for placental weight and other covariates. Compared with women who had a placental weight of less than 500 g, women who had a placental weight of at least 700 g had a 38 percent increase in risk of breast cancer.

"Our finding of a positive association between placental weight and breast cancer risk may reflect that exposures to elevated levels of pregnancy hormones influence the risk of breast cancer. The role of estrogens in breast carcinogenesis is well established, and serum estrogen levels are at least 10 times higher during pregnancy compared with other times of life," the authors write.

"In addition, placental weight appears to be a better indicator of the hormonal milieu than birth weight or other included birth parameters. Underlying biological mechanisms responsible for the observed associations may not only be limited to a direct growth enhancing effect on breast cells during childbearing, but also may be due to maternal characteristics or genetic factors associated with placental growth," the researchers conclude. (JAMA.2005; 294:2474-2480. Available pre-embargo to the media at www.jamamedia.org)


'"/>

Contact: Sven Cnattingius, M.D., Ph.D.
sven.cnattingius@mep.ki.se
JAMA and Archives Journals
15-Nov-2005


Page: 1 2

Related medicine news :

1. Higher intake of fish and vitamin D levels linked to lower risk of age-related macular disease
2. Higher gas prices leave many workers running on empty
3. Higher calcium and vitamin D intakes positively associated with brain lesions in older men and women
4. Higher physical activity associated with reduced risk of breast cancer
5. Higher levels of cells originating in bone marrow may be useful in prognosis of liver cancer
6. Higher blood pressure associated with decline in walking ability in older persons
7. Higher levels of obesity associated with greater health risks
8. Higher death rates associated with increasing degrees of obesity, PITT researchers report
9. Higher strength MRI can help patients avoid arthroscopy for shoulder injuries
10. Higher self-awareness of memory complaints predict brain function decline
11. Higher rates of infection may explain why women have higher risk of death after bypass surgery

Post Your Comments:
(Date:10/31/2014)... HealthDay Reporter THURSDAY, Oct. 30, 2014 ... transplantation is nothing new. The first kidney transplant took ... 1963 and the first human heart transplant in 1967. By ... entire face. One major organ still eludes the transplant ... of U.S. scientists has its way, that dream may become ...
(Date:10/31/2014)... News) -- The number of medical malpractice payments in ... to a new study. And compensation payment amounts ... or declined in recent years, researchers report online Oct. ... Association . "For many physicians, the prospect of ... of modern clinical practice," researchers, led by Michelle Mello, ...
(Date:10/31/2014)... WASHINGTON, DC (October 31, 2014) — A new ... (Milken Institute SPH) at the George Washington University ... for pregnant women who are enrolled in Covered ... which includes the Comprehensive Perinatal Services Program (CPSP). ... the nation,s most successful programs ever developed for ...
(Date:10/30/2014)... day provide new treatments for injuries and damage to ... Cartilage, for example, is a hard material that caps ... smoothly. UC Davis biomedical engineers, exploring ways to toughen ... the body, report new developments this week in the ... . , "The problem with engineered tissue is that ...
(Date:10/30/2014)... group at the DFG Research Center for Regenerative Therapies ... (CRTD) demonstrated for the first time the in vitro ... dimensions from mouse embryonic stem cells. Correct spatial organization ... dorsal/ventral axis was observed., This study has been published ... Reports " on 30.10.2014 ., For many years Elly ...
Breaking Medicine News(10 mins):Health News:Scientists Set Their Sights on First Whole-Eye Transplant 2Health News:Scientists Set Their Sights on First Whole-Eye Transplant 3Health News:Fewer Malpractice Claims Paid in U.S. 2Health News:Report examines health care challenges for pregnant women enrolled in covered California 2Health News:Making lab-grown tissues stronger 2Health News:Reconstruction of a patterned piece of spinal cord in 3-D culture 2
(Date:10/30/2014)... 2014   ViaDerma, Inc. (OTCQB: VDRM), ... products to market, has recently released a revolutionary ... a topical liquid tetracycline-based antibiotic that uses a ... oral medication active ingredients into topical drugs. The ... antibiotic to help prevent skin infection in minor ...
(Date:10/30/2014)... , Oct. 30, 2014 China Biologic Products, ... leading fully integrated plasma-based biopharmaceutical company in ... to release third quarter 2014 financial results on Wednesday, ... The Company,s management will hold a conference call ... 2014, which is 8:30 p.m., Beijing Time on November ...
(Date:10/30/2014)... October 30, 2014 , ... LGG contribuye a adquirir tolerancia a la proteína ... la proteína de la leche de la vaca (APLV) ... infancia. Hasta ahora, la APLV se trataba eliminando ... ha demostrado que es posible adquirir tolerancia oral ...
Breaking Medicine Technology:ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3China Biologic to Report Third Quarter 2014 Financial Results 2Según expertos reunidos en el Simposio Allergy Day 2Según expertos reunidos en el Simposio Allergy Day 3
Cached News: