HOME >> MEDICINE >> NEWS
Hopkins geneticist discovers mutations in cancer cells that suggest new forms of treatment

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors, a discovery that could pave the way for more effective cancer treatments.

The Hopkins team, in conjunction with researchers at the J. Craig Venter Institute in Rockville, Md., discovered DNA abnormalities in two tyrosine kinase proteins already known to disrupt normal cell activity and contribute to tumor formation.

The discovery of these mutations is especially significant, the researchers say, because tyrosine kinases can be targeted using pharmaceuticals.

"We picked these proteins to sequence because receptor tyrosine kinases sit on the cell surface where anticancer drugs can get at them," said Gregory J. Riggins, M.D., co-lead author of the study and an associate professor in the Department of Neurosurgery at The Johns Hopkins University School of Medicine.

In the study, published in the October 4th edition of The Proceedings of the National Academy of Sciences, the researchers identified two of the previously unknown mutations in fibroblast growth receptor 1 (FGFR1) and one in platelet derived growth factor receptor alpha (PDGFRA).

FGFR1 and PDGFRA, said Riggins, have been implicated in several other cancers such as colorectal, breast and ovarian cancer, as well as chronic myelogenous leukemia, gastrointestinal stromal tumors and lymphoma.

Riggins and colleagues analyzed a catalog of 518 protein kinase sequences taken from the Human Genome Project. Using high-throughput gene sequencing equipment based at the Venter Institute's Joint Technology Center, they resequenced 20 targeted proteins from tissue samples of brain tumor cells from Hopkins. The cells came from 19 glioblastoma tumors from eight females and 11 males ranging in age from 7 to 77 years. Glioblastomas are malignant tumors of the central nervous system usually found in the cortex of the brain.

Researchers discovered the mutations after comparing the reseq
'"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
26-Sep-2005


Page: 1 2

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. Hopkins study reveals white blood cells can both hurt and help transplanted kidneys
4. Hopkins scientists link immune response to ghost parasites and severely congested sinuses
5. Hopkins-led study finds that chronic form of depression runs in families
6. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
7. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
8. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
9. Johns Hopkins lab scientists tame overactive CF protein
10. Hopkins researchers develop new quick tool to sort out insect bites in children
11. Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... , ... December 02, 2016 , ... ... announces the launch of its 60-day free trial program for all of the ... make the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers ...
(Date:12/2/2016)... ... ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of the print ... to practice medicine at an early age by his father, who was also a ... prescribing medicine,” he states. “It is about building relationships with people; relationships that are ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. ... will be included in the 2016 “Guide to America’s Top Plastic Surgeons” for ... the amalgamation of their education, experience, and professional associations. , One the ...
(Date:12/2/2016)... ... December 02, 2016 , ... CloudLIMS.com, a class-leading provider ... CloudLIMS Lite. CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep track ... The new version is a faster and a more efficient product, allowing batch ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... Sourced from ... has some unique properties including its unmatched natural purity of just 6 ppm TDS ... and crisp. , Nothing Water has been available in several ShopRite and FoodTown stores ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Research and Markets has announced the addition of the "Global Ultrasound ... report to their offering. ... The global ultrasound device market accounted ... grow at a CAGR of 5.5% during 2016-2022. Based on portability, the ... period, a CAGR of 8.8% in the global market. Among the various ...
(Date:12/2/2016)... 2016 On Thursday, December 1st ... in research, development and innovation in the biopharmaceutical industry ... held in the presence of Sergey Tsyb, Vice Minister ... Federation , Natalia Sanina, First Vice Chairman of ... Head of Roszdravnadzor, National Service of Control in Healthcare, ...
(Date:12/2/2016)... R.I. , Dec. 2, 2016 CVS ... its annual Analyst Day in New York City on Thursday, December 15, ... CVS Health leadership team will provide an in-depth review ... enhance shareholder value. The company will also discuss 2017 ... and video webcast of the event will be broadcast ...
Breaking Medicine Technology:
Cached News: