HOME >> MEDICINE >> NEWS
Hopkins scientists link immune response to 'ghost' parasites and severely congested sinuses

Although it's unclear why it's so, scientists at Johns Hopkins have linked a gene that allows for the chemical breakdown of the tough, protective casing that houses insects and worms to the severe congestion and polyp formation typical of chronic sinusitis.

A team of Hopkins sinus experts has found that the gene for the enzyme, acidic mammalian chitinase (AMCase), is up to 250 times more active in people with severe sinus inflammation that persists even after surgery when compared to patients in whom surgery is successful. Sinus surgery is usually the treatment of last resort for those who do not respond to drug therapy. But nearly one in 10 of those treated see symptoms return within weeks or months after surgery fails to keep open the nasal passages, scientists say.

The Hopkins report, published in the July issue of the American Journal of Rhinology, is believed to be the first to identify the enzyme's presence in the nose and confirm its link to sinusitis.

"This finding does not mean that there are actually parasites in the nose causing sinusitis, but our study does lend support to the concept that really severe and persistent sinusitis may be a case of a misplaced immune response directed against parasites that are not really there," says study lead author Andrew Lane, M.D., an associate professor at The Johns Hopkins University School of Medicine and director of its rhinology and sinus surgery center.

Previous research by other scientists had looked at the enzyme's tie-ins to asthma, which, like nasal polyps, is an inflammatory response of the body's immune system. The theory, Lane says, is that allergies and asthma result from genes that control the body's defenses against parasites, but these genes are dormant in healthy people. However, when turned on by so-called ghost parasites, the potent inflammatory response is medically very difficult to control.

Researchers say that although chitin, a rigi
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
6-Sep-2006


Page: 1 2 3 4

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. Hopkins study reveals white blood cells can both hurt and help transplanted kidneys
4. Hopkins-led study finds that chronic form of depression runs in families
5. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
6. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
7. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
8. Johns Hopkins lab scientists tame overactive CF protein
9. Hopkins researchers develop new quick tool to sort out insect bites in children
10. Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair
11. Tracking computer-based error reports improves patient safety, Hopkins study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... ... Feeding Matters , the first organization in the world dedicated to advancing the ... that the U.S. Centers for Disease Control and Prevention (CDC) has officially approved PFD ... U.S. International Classification of Diseases (ICD ) on October 1, 2021. ...
(Date:8/31/2020)... ... 31, 2020 , ... Just found out your dear friend has cancer? , It’s hard to ... family member shares their diagnosis. Once the shock wears off, the questions and fears can ... are the best ways to help? Words are failing me. I’m scared. I want to ...
(Date:8/31/2020)... Calif. (PRWEB) , ... August 31, 2020 , ... ... of business support services to dental groups in the United States, today announced ... the community of Beaumont, CA. , Patients will enjoy convenient hours, a ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... improve outcomes for patients with advanced heart failure, today announced that the company ... the amount of $555,358 from the National Heart, Lung, and Blood Institute of ...
(Date:8/28/2020)... DOWNERS GROVE, Ill. (PRWEB) , ... August 28, ... ... to COVID-19, The Nourished Group set out to continue helping the ... , attendees can discover new gluten-free products, get coupons, enter giveaways, chat with ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to ... businesses, schools and community organizations remain closed. Because about 80% of blood donations are ... of both blood donors and blood drive hosts to ensure blood products are readily ...
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its rapid national ... disinfection and deodorization provider - is proud to announce it has opened doors ... businesses and residents throughout the area. , Germinator provides a 100% safe and ...
(Date:8/27/2020)... CONSHOHOCKEN, Pa. (PRWEB) , ... August 27, 2020 ... ... and care coordination software, today announced the successful completion of their 2020 System ... as well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements ...
Breaking Medicine Technology:
Cached News: