HOME >> MEDICINE >> NEWS
Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair

In a dramatic display of stem cells' potential for healing, a team of Johns Hopkins scientists reports that they've engineered new, completed, fully-working motor neuron circuits -- neurons stretching from spinal cord to target muscles -- in paralyzed adult animals.

The research, in which mouse embryonic stem (ES) cells were injected into rats whose virus-damaged spinal cords model nerve disease, shows that such cells can be made to re-trace complex pathways of nerve development long shut off in adult mammals, the researchers say.

"This is proof of the principle that we can recapture what happens in early stages of motor neuron development and use that to repair damaged nervous systems," says Douglas Kerr, M.D., Ph.D., a neurologist who led the Hopkins team.

"It's a remarkable advance that can help us understand how stem cells can begin to fulfill their great promise," says Elias A. Zerhouni, director of the National Institutes of Health. "Demonstrating restoration of function is an important step forward, though we still have a great distance to go."

The researchers created what amounts to a cookbook recipe to restore lost nerve function, Kerr explains. The approach could one day repair damage from such diseases as ALS (Lou Gehrig's disease), multiple sclerosis or transverse myelitis or from traumatic spinal cord injury, the researchers say. "With small adjustments keyed to differences in nervous system targets," Kerr says, "the approach may also apply to patients with Parkinson's or Huntington's disease."

In a report on the study, to be released online June 26 in the Annals of Neurology, the Hopkins team says 11 of the 15 treated rats gained significant, though partial, recovery from paralysis after losing motor neurons to an aggressive infection with Sindbis virus -- one that, in rodents, specifically targets motor neurons and kills them. The animals recovered enough muscle strength to bear weight and step with the pre
'"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
21-Jun-2006


Page: 1 2 3 4

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. Hopkins study reveals white blood cells can both hurt and help transplanted kidneys
4. Hopkins scientists link immune response to ghost parasites and severely congested sinuses
5. Hopkins-led study finds that chronic form of depression runs in families
6. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
7. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
8. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
9. Johns Hopkins lab scientists tame overactive CF protein
10. Hopkins researchers develop new quick tool to sort out insect bites in children
11. Tracking computer-based error reports improves patient safety, Hopkins study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2018)... ... September 01, 2018 , ... ... add HydraFacial MD® Elite to its leading menu of results-driven aesthetic treatments. ... and an infusion of clinically-proven ingredients to dramatically improve your skin’s tone ...
(Date:9/1/2018)... ... 2018 , ... SignatureCare Emergency Center is looking to award their 2018 Fall ... deserving student. Get your applications in now as the deadline is approaching fast. (July ... is a medical student at Texas Southern University. Wu was inspired to go into ...
(Date:8/31/2018)... ... 31, 2018 , ... Becker's Healthcare is pleased to release ... community hospitals as well as facilities affiliated with large health systems. Some hospitals ... cities. The hospitals continue to grow in many communities, opening new departments and ...
(Date:8/31/2018)... ... 2018 , ... The social impact documentary feature film on homelessness, OFF THE ... researcher Luciana Lagana, aka Dr. Luciana, has been faring well at film festivals ... Festival, IndieFEST Film Awards, Shawna Shea Memorial Film Festival, and Top Indie Film Awards. ...
(Date:8/31/2018)... ... August 31, 2018 , ... Rudina Thanasi, ... of a biofield energy treated nutraceutical to improve overall immunity and to combat ... and blood, as well as, inflammation. The following data was reported:, ...
Breaking Medicine News(10 mins):
(Date:9/15/2018)... ... September 14, 2018 , ... ... incorporate deep sequencing to enable greater library coverage. However, severe gaps and ... potential hits remain. , Multiplexed phage display provides a simple, robust, and ...
(Date:9/13/2018)... ... ... Dr. Rod J. Rohrich is pleased to announce that registration is now open for ... the world, will take place from March 22nd and 23rd, 2019. The annual meetings ... surgical procedures and detailed analysis of revision rhinoplasty . Formats include lectures, discussion ...
(Date:9/12/2018)... ... September 12, 2018 , ... ... Express Surveys as part of its Population Engage patient experience suite. Express ... from patients, giving the provider organization a wealth of strategic and tactical knowledge ...
Breaking Medicine Technology:
Cached News: