HOME >> MEDICINE >> NEWS
Hopkins study reveals white blood cells can both hurt and help transplanted kidneys

In an example of biological irony, the same white blood cell chemistry known to damage kidneys used for transplants may also help prevent such damage, according to a federally funded study in genetically engineered mice at Johns Hopkins.

Researchers have long known that when blood flow is cut off and then returned to transplanted kidneys or other organs, immune system cells called T lymphocytes produce toxic natural chemicals that contribute to ischemic reperfusion injury (IRI). Nature cannot distinguish between deliberate surgical wounds needed to remove and re-implant a donor kidney and other kinds of organ damage in which certain toxic chemicals are needed to clean up or remove bad tissue.

But in the new study published in the September issue of The Journal of Immunology, the Hopkins team reports that that T cells can also play a role in reducing cellular damage in IRI kidneys, according to Hamid Rabb, M.D., medical director of kidney and pancreas transplantation at The Johns Hopkins University School of Medicine.

IRI occurs in 30 percent to 40 percent of kidneys removed from dead donors, resulting in lower kidney survival rates, shortened kidney life and a cost increase of approximately $20,000 per patient from the initial hospital stay and treatment alone, according to Rabb. Scientists therefore are interested in identifying means of preventing or rapidly treating IRI, but one barrier to greater understanding has been the inability to detect the lymphocytes in the kidney during the first critical six hours after blood flow is returned.

In the Hopkins study, designed to try to find these cells and learn more about IRI, white blood cells were taken from mice that had undergone experimentally induced IRI. These cells were injected into mice engineered without a thymus gland, which produces T cells. A comparison group of genetically engineered mice got no injections.

After the researchers temporarily stopped blo
'"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
20-Sep-2006


Page: 1 2 3

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. Hopkins scientists link immune response to ghost parasites and severely congested sinuses
4. Hopkins-led study finds that chronic form of depression runs in families
5. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
6. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
7. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
8. Johns Hopkins lab scientists tame overactive CF protein
9. Hopkins researchers develop new quick tool to sort out insect bites in children
10. Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair
11. Tracking computer-based error reports improves patient safety, Hopkins study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2019)... ... February 18, 2019 , ... ... Seal of Approval® for Health Care Staffing Services Certification. The certification demonstrates Highland ... , “Highland Medical Group is pleased to receive certification from The Joint Commission, ...
(Date:2/14/2019)... LAND, Texas (PRWEB) , ... February 14, 2019 ... ... Las Vegas, QT Medical announced the launch of its Personal Cardiac Assistant (PCA ... Several health trackers including Apple Watch 4 can record single lead ECGs and ...
(Date:2/13/2019)... ... February 13, 2019 , ... ... school locker rooms. Unfortunately, bullies also frequent hospital units, ambulatory care centers, clinics, ... , In this fully updated, second edition of What to Do When Nurses ...
(Date:2/13/2019)... ... 13, 2019 , ... Diameter Health , the leader in clinical data ... Security Management Act (FISMA) High General Support System Authority to Operate (ATO) for Diameter ... mandatory for the VA because of their work with confidential patient data. Protecting this ...
(Date:2/13/2019)... ... February 13, 2019 , ... Dr. Jig Patel and the dental ... an exceptionally talented and knowledgeable dentist from St. Louis, MO, to the ... such as CEREC same-day dentistry, root canals and emergency treatment. Dr. Patel, Dr. Merchant ...
Breaking Medicine News(10 mins):
(Date:2/13/2019)... ... 2019 , ... Researchers from the Icahn School of Medicine at Mount Sinai ... of the National Institutes of Health (NIH), for a five-year program called the U19 ... are to establish follicle-stimulating hormone (FSH), an important part of the reproductive system whose ...
(Date:2/13/2019)... ... February 13, 2019 , ... ... Vision Source ® as the recipients for the ‘Empower Your Care Teams ... which were announced at the 2019 HIMSS Annual Conference and Exhibition ...
(Date:2/13/2019)... ... 13, 2019 , ... Sensible Surrogacy today has launched a ... childless couples who are unable to afford the staggering cost of surrogacy in ... North America or Eastern Europe for legal and secure surrogacy procedures. However North ...
Breaking Medicine Technology:
Cached News: