Previous research has suggested that the long-term use of female hormone therapy is associated with an increased risk of developing breast cancer, according to background information in the article. However, most of the women in the largest studies have been white, and few studies have looked at the risks specifically in black women.

Lynn Rosenberg, Sc.D., of Slone Epidemiology Center, Boston University, and colleagues examined the association in 23,191 women age 40 years or older who were part of the Black Women's Health Study, conducted by investigators at Boston University and Howard University, Washington, D.C. The participants filled out an initial questionnaire about medical history, menopausal status and hormone use when they enrolled in the study in 1995. Follow-up questionnaires that also included questions about the development of breast cancer were completed every two years through the year 2003. The women's body mass index (BMI) was calculated by dividing their weight in kilograms by the square of their height in meters.

During the course of the study, 615 cases of breast cancer were reported. Breast cancer was more likely to occur in women who had taken hormones, including estrogen or estrogen plus progestin, in the previous two years than in women who had never taken hormones. The longer a woman took hormones, the more likely she was to develop breast cancer, and the risk was slightly higher for women taking estrogen with progestin than for those taking progestin alone. The association between hormone use and breast cancer was strongest for women who were lean, defined as having a BMI of less than 25.

"Associations of exogenous [supplemental] female hormone use with inc
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Contact: Lisa Brown
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JAMA and Archives Journals
10-Apr-2006