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Hormones could be prescription for living longer

The GHS treatment also was associated with a 1.4 Kg increase in lean body (muscle) mass and an improvement in tandem (heel-to-toe) walking at 6 months and in stair climbing at 12 months.

Hormone may hold clue to longevity

A protein derived from fat tissue may be an important determinant of longevity, suggests a study of 133 women, including 25 aged 100 to 102, whom researchers found had notably higher levels of adiponectin circulating in their blood. Adiponectin is a peptide that has anti-inflammatory properties, helps keep vessels clear of fatty deposits and plays an important role in metabolism, particularly of lipids and glucose. Insufficient levels of adiponectin are thought to contribute to obesity, insulin resistance, diabetes or the formation of lipid deposits in the arteries, collectively known as symptoms of metabolic syndrome.

The study, which was conducted by Agnieszka Baranowska-Bik, M.D., and colleagues from the Medical Centre of Postgraduate Education, Warsaw, Poland, looked at blood plasma concentrations of adiponectin in four groups of women: the 25 centenarians, 26 women aged 64 to 67, 45 between the ages of 20 and 43, and 37 obese women aged 26 to 54. Compared to the other groups, the oldest old had significantly higher concentrations of adiponectin as well as much lower levels of both leptin and insulin. Moreover, the oldest-old women scored better with respect to insulin resistance and total cholesterol. Compared to the obese women, who, as expected, had more evidence of metabolic disturbances, the centenarians had significantly fewer signs of hypertension and other symptoms characteristic of metabolic syndrome. Dr. Baranowska-Bik stops short of calling adiponectin the fountain of youth, but the results of this study, she argues, provide evidence that adiponectin may play an important role in longevity.

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21-Jun-2006


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