HOME >> MEDICINE >> NEWS
Hybrid molecule causes cancer cells to self-destruct

By joining a sugar to a short-chain fatty acid compound, Johns Hopkins researchers have developed a two-pronged molecular weapon that kills cancer cells in lab tests. The researchers cautioned that their double-punch molecule, described in the December issue of the journal Chemistry & Biology, has not yet been tested on animals or humans. Nevertheless, they believe it represents a promising new strategy for fighting the deadly disease.

"For a long time, cancer researchers did not pay much attention to the use of sugars in fighting cancer," said Gopalan Sampathkumar, a postdoctoral fellow in the university's Department of Biomedical Engineering and lead author of the journal article. "But we found that when the right sugar is matched with the right chemical partner, it can deliver a powerful double-whammy against cancer cells."

Sampathkumar and his colleagues built upon 20-year-old findings that a short-chain fatty acid called butyrate can slow the spread of cancer cells. In the 1980s, researchers discovered that butyrate, which is formed naturally at high levels in the digestive system by symbiotic bacteria that feed on fiber, can restore healthy cell functioning.

Efforts to use butyrate as a general drug for tumors elsewhere in the body, however, have been hindered by the high doses of the compound needed to effectively eradicate cancer. To get around this problem, scientists have tried to make butyrate more potent by modifying it or joining it to other compounds. Usually, the results have been disappointing because the molecular partner added to butyrate to improve delivery to the cancer cells often produced unsafe side effects.

In some of the less successful experiments, designed to avoid toxic side effects, researchers used innocuous sugar molecules such as glucose to carry butyrate into the cells. The Johns Hopkins team tried a different tack. "We didn't think they chose the right partner molecule," said Kevin J. Ya
'"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
3-Jan-2007


Page: 1 2 3

Related medicine news :

1. Scientists from the CIMA investigate a molecule for diagnosing hypertensive cardiopathy
2. Electric jolt triggers release of biomolecules, nanoparticles
3. Case and Cleveland Clinic researchers identify molecule in age-related macular degeneration
4. Researchers find molecule that may hold key to learning and memory
5. UCSF research pinpoints brain molecules role in developing addiction
6. Study identifies molecule essential for proper localization of blood stem cells
7. Research clarifies how brain replenishes memory-making molecules
8. Cellular molecule spurs growth of prostate cancer
9. Study broadens understanding of enzymes linked to tumor promoting molecule
10. Notch signaling molecule important in type 2 immunity
11. Researchers develop new concept for single molecule transistor

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... ... a fine examination of how God handles sin, including how to let go of ... who, for over ten long years has been waiting to release this powerful insight about ... has been serving the Lord for over twenty years, and he has been preaching and ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a ... “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired ... collections. , “I have been writing since high school and have many different ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... an On-demand E-learning system for Clinical and Regulatory education for Physicians, Physician ... on Aerolib`s successful education methodology of Disease Specific Documentation Improvement. , The ...
(Date:1/19/2017)... Beach, Florida (PRWEB) , ... January 19, 2017 , ... ... J.D., LCSW, announced that the name of their drug rehab center in Delray Beach, ... time we recognize that not only stars such as Philip Seymour Hoffman and Chris ...
(Date:1/19/2017)... ... ... Cosmetic Town, an online plastic surgery community, begins 2017 with an update ... their readers to get the information they desire. The procedures are now listed according ... on those particular areas. , “We are excited to streamline our listings in a ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Report Details ... Alzheimer,s Disease ... Companies – our new study reveals trends, R&D progress, ... events affecting the Alzheimer,s disease therapeutics and diagnostics market. ... key questions: - How is the Alzheimer,s disease therapeutics ...
(Date:1/19/2017)... , Jan. 19, 2017 Many patients don,t ... their medication when a pharmacy just a few blocks ...  To alleviate this problem Medicationdiscountcard.com has created ... see exactly how much their medication will cost at ... Easy Medicationdiscountcard.com takes ...
(Date:1/19/2017)... , January 19, 2017 Incretin Mimetics/GLP-1 ... and Others The global anti-obesity drugs market ... first half of the forecast period and CAGR of 38.7% in ... to grow at a CAGR of 32.8% from 2016 to 2027. ... in 2021, and $24,063 million in 2027. ...
Breaking Medicine Technology:
Cached News: