HOME >> MEDICINE >> NEWS
Identification of role for proteins in children's muscle disease could open up new treatment options

A study presented by Mrs. Elisabeth Elst today shows for the first time that a protein - heat shock protein 60 (HSP60) that is present in chronic inflammations, triggers a response by T-cells (a type of white blood cells that plays a part in the body's own immune response) in children with juvenile dermatomyositis (JDM).

The specific response has earlier been observed in juvenile idiopathic arthritis, but to date, little is known about the role of HSP60 in inflammatory myositis. Inflammatory myositis (IM) is the name given to a group of diseases that cause inflammation in the muscles of the body, which is mediated by the immune system of the body. The main symptoms are pain and weakness and can cause patient disability because of damage to the muscles. The main types of IM are dermatomyositis and polymyositis.

For children, the conditions of myositis are complex and are characterized by muscle damage due to an inflammatory process of the blood vessels that lie under the skin and muscles. Some of the symptoms include skin changes around the eyelids and over the knuckles and finger joints, as well as weakness in muscles, mainly affecting the large muscles around the hips and shoulders resulting in increased difficulty with walking, climbing stairs, getting up from the floor and lifting the arms. The children also often become uncharacteristically miserable and fractious and they may complain of tummy pain.

Heat shock proteins (HSP) are a group of proteins whose expression is increased when the cells are exposed to elevated temperatures. Production of high levels of heat shock proteins can also be triggered by exposure to different kinds of environmental stress conditions, such as infection, inflammation, exposure of the cell to toxins (e.g. ethanol, arsenic, and ultraviolet light), or water deprivation.

Mrs. Elst, pediatric immunologist at the University Medical Centre Utrecht, said, "We have shown for the first time that HSP60 pla
'"/>

Contact: Mia Gannedahl
mia_gannedahl@uk.cohnwolfe.com
44-207-331-2325
European League Against Rheumatism
22-Jun-2006


Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Head and neck cancer vaccine targets proteins to create immune response
3. Sticky proteins provide new insight into drug action
4. First major study of mammalian disorderly proteins
5. Keep the baby, toss the bathwater: How kidneys retain proteins, discard waste
6. Measuring proteins in spinal fluid may provide early clue to Alzheimers disease
7. Mechanism for neurodenegerative diseases linked to transport proteins
8. New test to detect rare proteins in blood
9. 200 proteins which detect diseases of the liver
10. Researchers find multiple proteins that stick to medical devices
11. Molecular ballet unravels, links proteins so cell can direct own movement

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/2/2020)... ... April 02, 2020 , ... FDA ... Webinar, Tuesday April 7, 2020, 1:30-3:00 p.m. EDT, https://www.fdanews.com/cdssoftwareregulation ... AI used to guide clinical management of the Coronavirus.* , Is one’s software ...
(Date:4/2/2020)... , ... April 02, 2020 , ... Since the onset ... food safety standards and practices. GoParrot ( https://www.goparrot.ai/ ) founder Yaniv Nissim has ... specialize in virus control and food safety, has created new standards for delivering food ...
(Date:4/1/2020)... ... April 02, 2020 , ... Medical Device Change Management, An ... https://www.fdanews.com/mdchangemanagement , What change management method should one be using for a ... dependent on the type of change. Is it due to post-market design change, production ...
(Date:4/1/2020)... ... April 01, 2020 , ... Velocidy Bio ’s ... revolutionary NEXTGENPCR that decreases the testing time for SARS-CoV-2 to eight minutes, ... unit the size of a shoebox could perform a hundred and eighty (180) amplification ...
(Date:3/30/2020)... ... March 30, 2020 , ... Achieve ... continuing its commitment to provide comprehensive and compassionate mental health and wellness services ... Medical Center’s UpDox platform for telemedicine services including initial consultations, evaluations, and follow-up ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... ... April 02, 2020 , ... NCPDP has elected its ... Meeting of the NCPDP Board of Trustees on Wednesday, May 6, 2020. , ... M.B.A., PBM Practice Lead, Point-of-Care Partners, newly elected to the Board of Trustees. , ...
(Date:4/2/2020)... ... 02, 2020 , ... On April 15, the Center for ... annual Medical Hero Appreci-a-thon to bring the global clinical research community together to ... and study volunteers. CISCRP invites the public to participate in this free ...
(Date:4/1/2020)... ... April 01, 2020 , ... As the coronavirus pandemic ... care and accessible primary care, launches its telemedicine platform, AFC/TeleCare, as a solution ... now provide virtual visits, allowing our medical providers to easily connect with patients ...
Breaking Medicine Technology:
Cached News: