HOME >> MEDICINE >> NEWS
Immune signals of variations of a single gene linked to more severe Crohn's disease

LOS ANGELES− Building on previous evidence supporting the theory that the pathophysiology of Crohn's Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease, particularly among Ashkenazi Jews. The findings, presented at the annual meeting of the American Gastroenterological Association, were reported by researchers from Cedars-Sinai Medical Center, the University of Washington and Mount Sinai School of Medicine.

Crohn's Disease is an inflammatory bowel disease that causes inflammation or ulceration of the gastrointestinal tract and can sometimes run in families. While the cause is unknown, many professionals believe that the body's immune system may overreact to normal intestinal bacteria or that disease-causing bacteria and viruses may play a role in triggering the condition.

The recent study, funded by the National Institutes of Health, shows the effect of one particular gene − a Crohn's Disease candidate gene named TLR 5 − on both Jews and non-Jews with the disease.

It is estimated that American Jews are three times more likely to develop Crohn's Disease than the population as a whole. Approximately 80 percent of the six million Jews in the United States are Ashkenazi Jews, an ethnic group whose ancestors are from eastern and central Europe,

As Jerome I. Rotter, M.D., first author of the study, director of research and co-director of the Medical Genetics Institute at Cedars-Sinai Medical Center explained, the innate immune system senses micro-organisms and pathogens using a family of proteins known as the Toll-Like Receptors (TLRs). This recognition activates both the innate and adaptive immune system, with each TLR recognizing a specific pattern of microbial components.

The aim of the study was to investigate three TLR5 gene variants and their relationship to Cr
'"/>

Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
23-May-2006


Page: 1 2

Related medicine news :

1. Immune responses in trachoma, and more
2. Immune system police learn early and sometimes badly
3. Immune culprit in malaria-associated anemia
4. Immune system response to viral DNA is unique
5. Immune therapy could treat leukemias, autoimmune diseases, transplant rejection
6. Immune factor GM-CSF significantly improves Crohns disease symptoms
7. Immune system lab model overcomes ethical limits on human hematopoietic stem cells studies
8. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
9. Targeted cancer drugs may work by disrupting balance of cellular signals
10. Newly discovered behavior in cancer cells signals dangerous metastasis
11. Nanowire arrays can detect signals along individual neurons

Post Your Comments:
(Date:12/19/2014)... If you have ever been unable to breathe, ... you had an arsenal of treatments to battle this ... breathing disorders. Currently, the only proven methods for controlling ... common treatments do exist. At the recent 2014 ... 34 asthma educators responded to a Harmonica Techs survey ...
(Date:12/19/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Gliquidone manufacturers and is a valuable source of ... the industry. , Firstly, the report provides a basic ... manufacturing technology. Then, the report explores the international and ...
(Date:12/19/2014)... THURSDAY, Dec. 18, 2014 (HealthDay News) -- A new ... -- moderate to severe hot flashes and night sweats ... bones. Hot flashes are common during menopause, affecting ... menopause also affect women after menopause, since they then ... "Our findings suggest women who exhibit moderate or ...
(Date:12/19/2014)... -- Traveling through the same U.S. airport gate, one ... within a four-hour time span, illustrating just how easily ... "The exposures in this report were not prolonged and ... highlighting the fact that measles is highly contagious," wrote ... specialist at the U.S. Centers for Disease Control and ...
(Date:12/17/2014)... Dr. Myo Nwe is the co-author of a new weight ... co-founder of the Ace Medical Weight Loss Center in Rock ... look at the industry of weight loss, and how several ... and in television shows, however, she says the topic of ... played for basic laughs, which she believes impacts whether Americans ...
Breaking Medicine News(10 mins):Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 4Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 5Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 6Health News:Severe Hot Flashes During Menopause May Raise Hip Fracture Risk Later: Study 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2
(Date:12/17/2014)... NASHVILLE, Tenn. , Dec. 17, 2014  Strategic ... health management software solutions, today announced a strategic agreement ... the New Jersey regional marketplace.  ... and enhance the health and wellness solutions QualCare brings ... and the surrounding region. QualCare ...
(Date:12/17/2014)... 17, 2014 , ... a hub of information concerning the biopharmaceutical Group,s national and ... further addition to the recently launched institutional website that is ... been enriched by a new chapter in the fascinating story ... richly detailed and panoramic hub on the world of clinical ...
(Date:12/17/2014)... and RALEIGH, N.C. , ... Communications, LLC (CTMC), and Integrated Clinical Trial Services, ... and retention for clinical trials announce that they ... Trial Marketing Services (i-CTMS). i-CTMS will provide a ... to pharmaceutical, biotechnology and medical device companies. ...
Breaking Medicine Technology:Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 2Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3
Cached News: