HOME >> MEDICINE >> NEWS
Immune signals of variations of a single gene linked to more severe Crohn's disease

LOS ANGELES− Building on previous evidence supporting the theory that the pathophysiology of Crohn's Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease, particularly among Ashkenazi Jews. The findings, presented at the annual meeting of the American Gastroenterological Association, were reported by researchers from Cedars-Sinai Medical Center, the University of Washington and Mount Sinai School of Medicine.

Crohn's Disease is an inflammatory bowel disease that causes inflammation or ulceration of the gastrointestinal tract and can sometimes run in families. While the cause is unknown, many professionals believe that the body's immune system may overreact to normal intestinal bacteria or that disease-causing bacteria and viruses may play a role in triggering the condition.

The recent study, funded by the National Institutes of Health, shows the effect of one particular gene − a Crohn's Disease candidate gene named TLR 5 − on both Jews and non-Jews with the disease.

It is estimated that American Jews are three times more likely to develop Crohn's Disease than the population as a whole. Approximately 80 percent of the six million Jews in the United States are Ashkenazi Jews, an ethnic group whose ancestors are from eastern and central Europe,

As Jerome I. Rotter, M.D., first author of the study, director of research and co-director of the Medical Genetics Institute at Cedars-Sinai Medical Center explained, the innate immune system senses micro-organisms and pathogens using a family of proteins known as the Toll-Like Receptors (TLRs). This recognition activates both the innate and adaptive immune system, with each TLR recognizing a specific pattern of microbial components.

The aim of the study was to investigate three TLR5 gene variants and their relationship to Cr
'"/>

Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
23-May-2006


Page: 1 2

Related medicine news :

1. Immune responses in trachoma, and more
2. Immune system police learn early and sometimes badly
3. Immune culprit in malaria-associated anemia
4. Immune system response to viral DNA is unique
5. Immune therapy could treat leukemias, autoimmune diseases, transplant rejection
6. Immune factor GM-CSF significantly improves Crohns disease symptoms
7. Immune system lab model overcomes ethical limits on human hematopoietic stem cells studies
8. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
9. Targeted cancer drugs may work by disrupting balance of cellular signals
10. Newly discovered behavior in cancer cells signals dangerous metastasis
11. Nanowire arrays can detect signals along individual neurons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: a moving compilation of ... value to God. “Letters From Home” is the creation of published author, John Allred, ... Cabinet of Jerry Savelle Ministries International, who has traveled and ministered on four continents. ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... tick-borne diseases through research, education and awareness, today announced the appointment of Timothy ... and microbiologist, Dr. Sellati has more than 20 years of research experience with ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process Capability Indices ... – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      , Quality in ... afoul of The Quality System Regulation (§820.250), and Devicemakers find themselves staring at ...
(Date:9/21/2017)... VA (PRWEB) , ... September 21, 2017 , ... ... , **An FDAnews Management Report**, http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world ... they can get while staying in compliance with FDA rules. , The FDA ...
(Date:9/21/2017)... ... 2017 , ... Bill Howe Plumbing’s mission is to create an employee friendly ... community. For over 37 years, they have operated with their mission at the foundation ... San Diego. They were chosen as the Best San Diego plumber in 2016, named ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... ... DC ... th – Monday, September 18 th .The Brain Tumor Foundation (BTF) ... to the public.Where:  BTF,s Mobile MRI Unit – ... NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road to Early Detection ...
(Date:9/7/2017)... , Sept. 7, 2017  For nearly two decades, New Life Agency ... Assisted Reproduction Insurance industry. Today, New Life Agency announces a powerful three-way ... ... ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ...
(Date:9/7/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... clinical grade cell and tissue hypothermic storage and ... Rice , President and CEO, will be presenting at two ... & Renshaw 19 th Annual Global Investment Conference on ... Pacific time). The conference is being held at the New ...
Breaking Medicine Technology:
Cached News: