HOME >> MEDICINE >> NEWS
Impaired gene helps non-small cell lung cancer resist drug

HOUSTON - Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease, researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Southwestern Medical Center at Dallas report in the cover article of the Oct. 1 edition of Cancer Research.

The gene may provide a potential biomarker for selecting among chemotherapy choices for non-small-cell lung cancer as well as a therapeutic target for restoring the drug cisplatin's punch in treating resistant forms of the disease, says senior author Lin Ji, Ph.D., associate professor in M. D. Anderson's Department of Thoracic and Cardiovascular Surgery.

Researchers at the two institutions, working under a joint National Cancer Institute Specialized Program of Research Excellence (SPORE) in Lung Cancer grant, have identified three tumor-suppressor genes on chromosome 3. The latest paper refines the impact of one of those genes, NPRL2, on the most common form of lung cancer.

"NPRL2 has potential predictive value for care," Ji said. "If a patient's non-small-cell lung cancer lacks an active NPRL2 gene, then cisplatin likely would not be a suitable chemotherapy."

Researchers started by analyzing NPRL2 expression in 40 different lines of non-small-cell lung cancer. They found that 21 lines expressed the gene and of those 15 lines were sensitive to cisplatin. The other 19 lines had little or no expression of NPRL2 and 15 of those were cisplatin-resistant.

Follow-up laboratory experiments with resistant cell lines showed that NPRL2 expression with cisplatin drastically limited cancer cell proliferation and increased programmed cell death (apoptosis) of cancer cells by 2 to 3 fold.

"We also demonstrated in a mouse model of human cisplatin-resistant non-small-cell lung cancer that gene therapy to restore NPRL2's function makes the tumors o
'"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
1-Oct-2006


Page: 1 2

Related medicine news :

1. Impaired vision common in US
2. Device helps physically disabled turn on computer
3. Case study: cross-cultural bioethics training program helps fight African brain drain
4. New drug development facility helps move medicines to market
5. Research shows aerobic exercise helps maintain muscle in elderly
6. Virtual autopsy helps identify drowning as cause of death
7. Topical retinol helps reduce wrinkles associated with natural skin aging
8. Transplanting human gut bugs into mice helps understanding of metabolic system
9. Quick, innovative procedure helps men minimize incontinence after prostatectomy
10. New research helps overcome major CPAP problem
11. MS drug helps reduce vision loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2019)... ... April 18, 2019 , ... Dr. Matt Nejad is a ... full menu of cosmetic and general dental care services. Dr. Nejad is most ... relies on minimally-invasive techniques in restorative dentistry. Biomimetic dentistry uses a more holistic ...
(Date:4/17/2019)... GULF BREEZE, Fla. (PRWEB) , ... April 17, 2019 , ... ... in the headlines, scientists are working to curb the death toll by looking for ... Society Spring 2019 National Meeting & Exposition this week. , Naloxone (often known ...
(Date:4/17/2019)... ... April 17, 2019 , ... Purple Biosciences today introduces Purple ... supplement was designed to lessen the negative effects of alcohol, so adults can ... GotPurpleTree.com and Amazon.com . , According to the Centers for Disease ...
(Date:4/17/2019)... ... April 17, 2019 , ... Signaled.online is a notification service designed ... alarm, monitoring of the web resources and reminder. , The alarm can be useful ... live alone. If you haven’t logged in to the website for several days (this ...
(Date:4/17/2019)... ... April 17, 2019 , ... Nastel Technologies is a ... Management (APM) for mission-critical applications in the mixed cloud environments. Nastel is entering ... XRay® for MQ. , Nastel XRay® for MQ, a Big Data analytics platform ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... ... Pennsylvania, Allegheny Health Network (AHN) and Gateway Health have launched a new program ... of life. , AHN’s Enhanced Pain Management Program brings together a range ...
(Date:4/17/2019)... , ... April 17, 2019 , ... The Job ... that will support investigation into the causes of and treatments for Job Syndrome. ... projects that will take place around the globe in three countries, and on three ...
(Date:4/17/2019)... ... April 17, 2019 , ... With the US Food ... to Expedite Development of Oncology Drugs and Biologics’ – it opens ... years of experience helping sponsors manage complex oncology trials, endpoint has ...
Breaking Medicine Technology:
Cached News: