Implant device effectively maintains heart function for transplant-listed patients

Whether a patient is awaiting a heart transplant or living with chronic heart failure, cardiologists are continuously looking for new therapies that address short-term and/or long-term needs of chronically impaired cardiac patients. Research presented today at the American College of Cardiology's 56th Annual Scientific Session reviewed new treatments and interventions, including LVAD implantation and diuretic therapies to support left ventricular function in severely compromised cardiovascular patients. ACC.07 is the premier cardiovascular medical meeting, bringing together cardiologists and cardiovascular specialists from around the world to further breakthroughs in cardiovascular medicine.

Multicenter Clinical Evaluation of the Heartmate II Continuous Flow Left Ventricular Assist System in Patients Awaiting Heart Transplantation (Presentation Number: 415-6)

Left ventricular assist device (LVAD) therapy is a life-saving technology for patients with heart failure. Mechanical circulatory support with an LVAD has become a standard therapy for patients with refractory heart failure as a bridge to heart transplantation. New devices are being examined for their safety and efficacy in this setting as well as in those who are deemed not eligible for heart transplantation.

One novel LVAD is called Heartmate II, which utilizes miniature continuous flow technology designed to provide mechanical circulatory support for years at a time. In a prospective, multi-center trial conducted at 26 sites in the US, 133 patients listed for heart transplantation and refractory to intravenous inotropic therapy, received a HeartMate II, which was then evaluated for safety and overall efficacy based on historical LVAD performance criteria.

Of the 133 patients, 75 percent achieved the primary endpoint, which was measured as survival to heart transplant or 180 days of device support. Actuarial survival rates were 77 percent after six mon

Contact: Leslie Humbel
American College of Cardiology

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