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Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys

acted from the carotid body have been used as a source for dopaminergic cells in the treatment of Parkinson's disease in animal experiments and in humans. The advantage of this cell type with respect to others is the possibility of carrying out autoimplants, thus avoiding tissue rejection or immunosupressor treatment.

Research

Research was undertaken with monkeys who had Parkinson's induced by the administration of a neurotoxin (MPTP) and which were subsequently injected into the striate area of the brain with fragments from the carotid body of the same animal This region of the brain where the fragments from the carotid body are implanted is the area where dopamine from the dopaminergic neurones is released from the black substance. As is known, Parkinson's disease is produced as a result of the loss of 50% of the cells of the black substance (the brain stem structure) that manufactures dopamine and sends out projections to the striate area.

In order to implant dopaminergic cells in the brain, it is necessary to effect a trepanation through which the fragments from the carotid are injected into the striate area of the animal's brain. This work shows that the number of striate dopaminergic neurones that the striate area of the brain usually contains undergoes an additional increase after the implantation of these cell aggregates. Moreover, this increase in the number of dopaminergic cells appears to be responsible for the improvement of the illness in animals studied by the Navarra University Hospital and CIMA researchers, given that, this was not observed in those individuals receiving injections of saline serum instead of the cellular aggregates.

The fact that the injection into the striate area of neurotrophic factors (those that favour cell growth), such as GDNF, also causes a significant increase in dopaminergic neurones in this region of the brain indicates that the beneficial effect produced by the implant of cel
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Contact: Egoitz Etxebeste
egoitz@elhuyar.com
Elhuyar Fundazioa
16-May-2007


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