Rates of mortality due to liver cirrhosis can indicate the extent of alcohol harm occurring in a population. David Leon (London School of Hygiene and Tropical Medicine, UK) and Jim McCambridge (King's College London, UK) calculated the mortality rates for liver cirrhosis using data from the World Health Organization Mortality Database. They calculated rates for all ages and specific age groups in Scotland, England and Wales and compared these to rates in 12 other western European countries Austria, Finland, Germany, Ireland, Italy, Netherlands, Norway, Portugal, Spain, Sweden, and Denmark.

The investigators found that mortality rates for liver cirrhosis increased steeply in Scotland, England and Wales during the 1990s. Steady increases took place until the end of the 1970s, and accelerated in the 1980s and again from 1990 to 1994 onwards. In comparison, mortality rates for both men and women in the other European countries declined by 20-30% from the early 1970s. Between the periods 1987-1991, and 1997-2001, cirrhosis mortality in men in Scotland more than doubled, and in England and Wales it rose by over two-thirds. For women, rates increased by a half in the same period. Across both age-groups and sexes, the liver cirrhosis mortality rates in Scotland are now about double that of the European comparison group.

The authors blame increases in alcohol consumption, particularly wine and spirits, as the main reason for the rise in liver cirrhosis mortality. Total recorded alcohol consumption doubled between 1960 and 2002. They add that increases in the rates of heavy drinking, obesity, and hepatitis C may have also contributed. In western Europe, the reduction in mortality rates from liver cirrhosis has been driven by a decline in overall alcohol consumption in the mainly wine-drin
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
5-Jan-2006