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Infection detectives use disease 'fingerprints' to track common infections in children

DALLAS - March 13, 2007 -- Infectious disease specialists at UT Southwestern Medical Center have found a new method for identifying suspect viruses and bacteria that cause some of the most common acute infections in children.

Traditionally, researchers have looked for clues to an infection by tracking down the virus or bacteria causing it. But that doesnt always work because the bacteria or virus may not be present in the blood or other easily accessible area.

Researchers at UT Southwestern, Childrens Medical Center Dallas and Baylor Institute for Immunology Research came up with a different approach analyzing the telltale "fingerprints" a disease leaves behind on cells involved in the immune response, and using that information to get a composite sketch of the infectious agent.

"We are genetically programmed to respond differently to different infections. We have developed the tools to understand that," said Dr. Octavio Ramilo, professor of pediatrics at UT Southwestern and lead author of a study appearing in the March edition of the journal Blood.

"Infectious diseases are the No.1 cause of death in the world. So we hope this eventually can be used not only to diagnose, but also to understand the prognosis and how the body is responding to therapy," he said.

Different viruses and bacteria trigger the activation of very specific genes that code for proteins called receptors in leukocytes, the white blood cells th at help the body fight infections. Researchers surmised that if they looked at the leukocytes, they could detect the specific pattern of receptors similar to a disease "fingerprint" and be able to identify which infection was present. The process to identify such biosignatures is called gene expression profiling, and its done using microarray analysis.

Researchers extracted genetic material called RNA from a drop of blood and placed it on a special gene chip called a microarray, wh
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Contact: Russell Rian
Russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
13-Mar-2007


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