HOME >> MEDICINE >> NEWS
Infectious disease researchers develop basis for experimental melanoma treatment

While investigating a fungus known to cause an infection in people with AIDS, two grantees of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), unexpectedly discovered a potential strategy for treating metastatic melanoma, one of the deadliest forms of skin cancer. The treatment approach, which involves combining an antibody with radiation, has since been further developed and is expected to enter early-stage human clinical studies in 2007.

"This is an excellent example of how scientific research in one discipline may have payoffs in a completely unpredictable way," says NIAID Director Anthony S. Fauci, M.D. "This important AIDS-related research has led to the development of a promising therapeutic strategy for a terrible cancer that affects thousands of people each year."

Arturo Casadevall, M.D., Ph.D., of the Albert Einstein College of Medicine at Yeshiva University, in New York City, and his research team began studying the biology of the skin pigment melanin to better understand why its synthesis plays a role in the process whereby certain yeast-like fungi, specifically Cryptococcus neoformans, cause disease in some people. C. neoformans can cause cryptococcosis, a potentially fatal fungal infection that can lead to inflammation of the brain and death in people with AIDS and other immunocompromised individuals.

The researchers created an infection-fighting antibody, known as a monoclonal antibody, that binds to melanin based on scientific evidence suggesting that when melanin is synthesized, it causes the immune system to react in a way that might create antibodies to fend off C. neoformans infection. Based on this finding, Dr. Casadevall theorized that melanomas might contain melanin that would allow the monoclonal antibody to deliver radiation to tumor cells. Dr. Casadevall then teamed with his colleague Ekaterina Dadachova, Ph.D., an expert in nuclear medicine a
'"/>

Contact: Kathy Stover
kstover@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
7-Dec-2006


Page: 1 2 3

Related medicine news :

1. Infectious disease doctors respond to President Bushs strategy on pandemic influenza
2. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
3. Smoking may strongly increase long-term risk of eye disease
4. Pot bellies linked to early signs of cardiovascular disease
5. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
6. 1 of 2 pediatric kidney disease research centers in world established
7. Reductive stress linked to heart disease
8. Obesity linked to hyperparathyroidism in chronic kidney disease
9. Wireless technology shows promise in diagnosing pediatric intestinal disease
10. Researchers link metal ions to neurodegenerative disease
11. Green tea holds promise as new treatment for inflammatory skin diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... ... May 03, 2016 , ... ... creative director Joe Ferrazano to serve in the newly created position of executive ... overseeing the agency’s creative efforts in the Chicago and LA offices. He reports ...
(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... ... accredited American online university, has announced today the launch of its Associates and ... Laureate and President Emeritus of The Rockefeller University, Dr. Torsten N. Wiesel; Chairman ...
(Date:5/3/2016)... Toledo, OH (PRWEB) , ... May 03, 2016 , ... ... remain a leading cause of death across the United States and account for one ... physical and mental impairments or are permanently disabled. HCR ManorCare is launching a video ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... Canada’s top Information and Communication Technology (ICT) companies in the annual Branham300 listing. ... companies operating in Canada, as ranked by revenue. , “We are honored ...
(Date:5/3/2016)... Miami, FL (PRWEB) , ... May 03, 2016 , ... ... support both its Grow & Climb children and youth programs in South Miami. Macy’s ... several years. , The Grow Program provides afterschool tutoring, mentoring, enrichment and academic ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016  In the next ten ... shift from systems dependent on CRTs monitors to those ... modality CRT Medical monitors and will automatically sync ... host of foreseeable benefits to this technological advancement, ... modalities have to be replaced in order to ...
(Date:4/29/2016)... Glycotope GmbH, a clinical-stage immuno-oncology ... appointment of Dr. Alfredo Zurlo as Chief ... with many years clinical experience and a proven track ... role was at Mologen AG where he was Chief ... Dr. Zurlo held various positions at F Hoffmann La ...
(Date:4/28/2016)... April 28, 2016 Research and ... Plastic Surgery Products Market 2016-2020" report to their ... , The global plastic surgery products market ... during the period 2016-2020. , ,The growing adoption of ... the growth of the market. Lasers are used to ...
Breaking Medicine Technology:
Cached News: