HOME >> MEDICINE >> NEWS
Infectious disease researchers develop basis for experimental melanoma treatment

While investigating a fungus known to cause an infection in people with AIDS, two grantees of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), unexpectedly discovered a potential strategy for treating metastatic melanoma, one of the deadliest forms of skin cancer. The treatment approach, which involves combining an antibody with radiation, has since been further developed and is expected to enter early-stage human clinical studies in 2007.

"This is an excellent example of how scientific research in one discipline may have payoffs in a completely unpredictable way," says NIAID Director Anthony S. Fauci, M.D. "This important AIDS-related research has led to the development of a promising therapeutic strategy for a terrible cancer that affects thousands of people each year."

Arturo Casadevall, M.D., Ph.D., of the Albert Einstein College of Medicine at Yeshiva University, in New York City, and his research team began studying the biology of the skin pigment melanin to better understand why its synthesis plays a role in the process whereby certain yeast-like fungi, specifically Cryptococcus neoformans, cause disease in some people. C. neoformans can cause cryptococcosis, a potentially fatal fungal infection that can lead to inflammation of the brain and death in people with AIDS and other immunocompromised individuals.

The researchers created an infection-fighting antibody, known as a monoclonal antibody, that binds to melanin based on scientific evidence suggesting that when melanin is synthesized, it causes the immune system to react in a way that might create antibodies to fend off C. neoformans infection. Based on this finding, Dr. Casadevall theorized that melanomas might contain melanin that would allow the monoclonal antibody to deliver radiation to tumor cells. Dr. Casadevall then teamed with his colleague Ekaterina Dadachova, Ph.D., an expert in nuclear medicine a
'"/>

Contact: Kathy Stover
kstover@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
7-Dec-2006


Page: 1 2 3

Related medicine news :

1. Infectious disease doctors respond to President Bushs strategy on pandemic influenza
2. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
3. Smoking may strongly increase long-term risk of eye disease
4. Pot bellies linked to early signs of cardiovascular disease
5. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
6. 1 of 2 pediatric kidney disease research centers in world established
7. Reductive stress linked to heart disease
8. Obesity linked to hyperparathyroidism in chronic kidney disease
9. Wireless technology shows promise in diagnosing pediatric intestinal disease
10. Researchers link metal ions to neurodegenerative disease
11. Green tea holds promise as new treatment for inflammatory skin diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2017)... ... May 28, 2017 , ... ... proud to announce that Jorge Fernandez-Silva, M.D., has joined its new Melbourne pain ... specialty that concentrates on minimally invasive techniques to treat and manage many types ...
(Date:5/27/2017)... ... 2017 , ... A May 8 article on CBCNews reports that ... issues that are not responsive to antibiotics nevertheless obtain prescriptions for them. The article ... for the problem both in Canada and the United States. Dr. Michael Farzam of ...
(Date:5/27/2017)... ... May 27, 2017 , ... From May 21-23, hearing healthcare ... three-day event was held at the Marriott Syracuse Downtown Hotel in Syracuse, New York. ... and network of independent hearing healthcare providers to help them stay ahead in the ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... week to review more than eighty-nine grant submissions all vying for nearly $1,000,000 ... in the Parkinson’s field.     , The American Parkinson Disease Association (APDA) is focused ...
(Date:5/26/2017)... Plano, Texas (PRWEB) , ... May 26, 2017 , ... ... Cord Stimulation System, a powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita ... , “We are pleased to be the first in Arkansas to introduce the ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... May 9, 2017  Semler Scientific, Inc. (OTCQB: ... solutions to improve the clinical effectiveness and efficiency ... the first quarter ended March 31, 2017. ... our customers to identify when preventive care options ... events like heart attacks or strokes occur," said ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. ... Communications, Inc. ("WRB"), a health care service center ... WRB specializes in relationship management programs for ... WRB will join ... commercialization support services for manufacturers, biotech firms, and other ...
(Date:5/6/2017)... CHICAGO , May 5, 2017  May is ... of one of the most important methods to prevent ... to the Centers for Disease Control and Prevention, undetected ... stroke. 1 Omron, the global leader in personal ... on the elimination of heart attack and stroke and ...
Breaking Medicine Technology:
Cached News: