HOME >> MEDICINE >> NEWS
Inflammatory processes in arteriosclerosis revealed

Revolutionary new results concerning substances that play major roles in the inflammatory response have been published in the American scientific journal PNAS in two articles from Karolinska Institutet. Inflammation is important in, for example, cardiovascular disease. The results open the way for the development of new drugs both for prevention and for treatment.

Conditions and diseases that involve inflammation include severe infection, arthritis, asthma and arteriosclerosis. Certain substances, such as cytokines, are formed during the inflammation response and contribute to its various aspects. Professor Jesper Haeggstrm and his group, working in close collaboration with Professor Jan Palmblad's group, show in the first of two articles published in Proceedings of the National Academy of Sciences (2 May 2006) that several of these substances can influence the cells of the blood vessel wall such that they start to express receptors for a leukotriene, LTB4.

This enables the cells to react to LTB4 and to transmit signals that reinforce the inflammation. LTB4 is a powerfully chemotactic and immuno-modulating substance that is important for the motion of white blood cells over the walls of the blood vessel when the tissue becomes damaged and inflamed. It has previously been believed that the cells of the blood vessel wall are silent, unable to react to LTB4.

The demonstration of new factors that control the interplay between the blood vessel cells and the white blood cells that are crucial in the inflammatory process will enable the development of new drugs to be targeted against these factors. New drugs may in the long term become available for use during chronic inflammation such as arthritis, asthma and cardiovascular disease.

The second of the two articles presents the first report of a study that has been carried out in collaboration with arteriosclerosis researchers and surgeons at the Karolinska Univer
'"/>

Contact: Sara Aldn
sara.alden@ki.se
46-703-586-326
Karolinska Institutet
18-Jul-2006


Page: 1 2

Related medicine news :

1. Inflammatory system genes linked to cognitive decline after heart surgery
2. Inflammatory bowel disease doubles risk of pregnancy complications
3. Crohns & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases
4. Inflammatory biomarker helps identify progressive precancerous lesions in the lung
5. Inflammatory markers may help predict stroke risk in middle-aged people
6. Discovery of cellular processes which regulate hearts energy supply
7. Early onset of poor bone mineralization revealed in children with cystic fibrosis
8. Mechanism of black cohosh versus hot flashes revealed
9. Key to lung cancer chemo resistance revealed
10. Details of solar particles penetrating the Earths environment revealed
11. Healing honey: The sweet evidence revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... ... One thing common to all types of cancer is that it’s a ... money spent screening for and treating cancer in the United States is estimated to ... than in any other country that has an advanced healthcare system, sometimes spending as ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... been appointed Chief Executive Officer of the medical device company, effective immediately. , ... Robert Storey. “Kevin has a strong track record in medical device market ...
(Date:1/15/2017)... ... ... In this role, Courtney will be responsible for developing new business initiatives ... mark. This certification program was created by ASL and the nonprofit Asthma and Allergy ... for the 60+ million people living in the U.S. with asthma and allergies. Courtney ...
(Date:1/15/2017)... , ... January 15, 2017 , ... Whole Health Supply, LLC is announcing the release ... are also new avenues for purchase. , The 2017 edition has wide jaws that ... for the older boomers as well as diabetics. This handle is reinforced for extra strength ...
(Date:1/15/2017)... Viejo, California (PRWEB) , ... January 15, 2017 , ... ... a stylistic slideshow with complete customization and ease," said Christina Austin - CEO of ... of controls so that users can edit the style and animation of their slideshows. ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017  Tetra Discovery Partners today ... as Vice President, Clinical Operations. He joins ... Executive Director, Clinical Project Management. "Richard joins ... experience in global clinical research planning and execution, ... clinical operation build-outs and development partnerships," said ...
(Date:1/17/2017)... 17, 2017 - First major agreements signed ... market expected to grow by a CAGR of approximately 6-9% ... holding company which operates globally across a number of sectors, announces ... of notable successes and is well-positioned for further expansion within the ... ...
(Date:1/16/2017)... , Jan. 16, 2017  An aneurysm develops due ... balloon-like dilation. Aneurysms can occur in any artery, ... blood vessel that supplies blood to legs. Most aortic aneurysms ... the abdomen and are referred as abdominal aortic aneurysms, sometimes ... diameter of the aorta in the abdomen is about 2 ...
Breaking Medicine Technology:
Cached News: