HOME >> MEDICINE >> NEWS
Inflammatory processes in arteriosclerosis revealed

Revolutionary new results concerning substances that play major roles in the inflammatory response have been published in the American scientific journal PNAS in two articles from Karolinska Institutet. Inflammation is important in, for example, cardiovascular disease. The results open the way for the development of new drugs both for prevention and for treatment.

Conditions and diseases that involve inflammation include severe infection, arthritis, asthma and arteriosclerosis. Certain substances, such as cytokines, are formed during the inflammation response and contribute to its various aspects. Professor Jesper Haeggstrm and his group, working in close collaboration with Professor Jan Palmblad's group, show in the first of two articles published in Proceedings of the National Academy of Sciences (2 May 2006) that several of these substances can influence the cells of the blood vessel wall such that they start to express receptors for a leukotriene, LTB4.

This enables the cells to react to LTB4 and to transmit signals that reinforce the inflammation. LTB4 is a powerfully chemotactic and immuno-modulating substance that is important for the motion of white blood cells over the walls of the blood vessel when the tissue becomes damaged and inflamed. It has previously been believed that the cells of the blood vessel wall are silent, unable to react to LTB4.

The demonstration of new factors that control the interplay between the blood vessel cells and the white blood cells that are crucial in the inflammatory process will enable the development of new drugs to be targeted against these factors. New drugs may in the long term become available for use during chronic inflammation such as arthritis, asthma and cardiovascular disease.

The second of the two articles presents the first report of a study that has been carried out in collaboration with arteriosclerosis researchers and surgeons at the Karolinska Univer
'"/>

Contact: Sara Aldn
sara.alden@ki.se
46-703-586-326
Karolinska Institutet
18-Jul-2006


Page: 1 2

Related medicine news :

1. Inflammatory system genes linked to cognitive decline after heart surgery
2. Inflammatory bowel disease doubles risk of pregnancy complications
3. Crohns & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases
4. Inflammatory biomarker helps identify progressive precancerous lesions in the lung
5. Inflammatory markers may help predict stroke risk in middle-aged people
6. Discovery of cellular processes which regulate hearts energy supply
7. Early onset of poor bone mineralization revealed in children with cystic fibrosis
8. Mechanism of black cohosh versus hot flashes revealed
9. Key to lung cancer chemo resistance revealed
10. Details of solar particles penetrating the Earths environment revealed
11. Healing honey: The sweet evidence revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer ... to their footage. A LUT is a Lookup Table that contains a mathematical formula ... indicated by the table. By manipulating each pixel, LUT's can change each color range ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the air ... variety of colors, assortments and packaging. This staple for Valentine’s Day is a must-have, ... , For Valentine’s Day, not only are long-stem roses available, but also other ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held on ... Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research for ... Furniture, lives with Parkinson’s disease and is the architect of this informative event to ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... H. Van Allen have signed a joint enrollment and degree completion agreement. ... toward associate and baccalaureate degrees at FHU|Dickson. , The agreement allows students ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... from across the country gathered at the La Valencia Hotel in San Diego, ... PROSHRED Chicago was named the year’s most outstanding franchise, walking away with the ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) has ... Obstetrics Partnering 2010-2016: Deal trends, players and ... --> http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) has announced ... Partnering 2010-2016: Deal trends, players and financials" ... --> Research and Markets ( http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ...
(Date:2/4/2016)... , Feb. 4, 2016  The Senior Care ... Government Reform Committee Chairman Jason Chaffetz ... holding today,s hearing , "Developments in the ... increases and growing questions about abusive pharmacy benefit ... (R-UT) and Ranking Member Elijah Cummings (D-MD) ...
(Date:2/4/2016)... 4, 2016  SciClone Pharmaceuticals, Inc. (NASDAQ: ... entered into a settlement agreement with the United ... the SEC,s investigation into possible violations of the ... of the settlement agreement, SciClone has agreed to ... pre-judgment interest and a penalty.  This payment is ...
Breaking Medicine Technology:
Cached News: