HOME >> MEDICINE >> NEWS
Inflammatory processes in arteriosclerosis revealed

Revolutionary new results concerning substances that play major roles in the inflammatory response have been published in the American scientific journal PNAS in two articles from Karolinska Institutet. Inflammation is important in, for example, cardiovascular disease. The results open the way for the development of new drugs both for prevention and for treatment.

Conditions and diseases that involve inflammation include severe infection, arthritis, asthma and arteriosclerosis. Certain substances, such as cytokines, are formed during the inflammation response and contribute to its various aspects. Professor Jesper Haeggstrm and his group, working in close collaboration with Professor Jan Palmblad's group, show in the first of two articles published in Proceedings of the National Academy of Sciences (2 May 2006) that several of these substances can influence the cells of the blood vessel wall such that they start to express receptors for a leukotriene, LTB4.

This enables the cells to react to LTB4 and to transmit signals that reinforce the inflammation. LTB4 is a powerfully chemotactic and immuno-modulating substance that is important for the motion of white blood cells over the walls of the blood vessel when the tissue becomes damaged and inflamed. It has previously been believed that the cells of the blood vessel wall are silent, unable to react to LTB4.

The demonstration of new factors that control the interplay between the blood vessel cells and the white blood cells that are crucial in the inflammatory process will enable the development of new drugs to be targeted against these factors. New drugs may in the long term become available for use during chronic inflammation such as arthritis, asthma and cardiovascular disease.

The second of the two articles presents the first report of a study that has been carried out in collaboration with arteriosclerosis researchers and surgeons at the Karolinska Univer
'"/>

Contact: Sara Aldn
sara.alden@ki.se
46-703-586-326
Karolinska Institutet
18-Jul-2006


Page: 1 2

Related medicine news :

1. Inflammatory system genes linked to cognitive decline after heart surgery
2. Inflammatory bowel disease doubles risk of pregnancy complications
3. Crohns & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases
4. Inflammatory biomarker helps identify progressive precancerous lesions in the lung
5. Inflammatory markers may help predict stroke risk in middle-aged people
6. Discovery of cellular processes which regulate hearts energy supply
7. Early onset of poor bone mineralization revealed in children with cystic fibrosis
8. Mechanism of black cohosh versus hot flashes revealed
9. Key to lung cancer chemo resistance revealed
10. Details of solar particles penetrating the Earths environment revealed
11. Healing honey: The sweet evidence revealed

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Inflammatory processes arteriosclerosis revealed

(Date:8/31/2015)... ... August 31, 2015 , ... Wyoming Medical Center, an ... for its Clinical Documentation Improvement (CDI) and medical coding needs. Based on a ... - ezCAC is an enterprise-level coding solution that combines CDI, Coding, Quality and ...
(Date:8/31/2015)... ... ... The more hours young adults spend watching television each day, the greater ... a 15-year analysis by the University of Pittsburgh Graduate School of Public Health revealed. ... adulthood is an important time to intervene and promote less television viewing, according to ...
(Date:8/31/2015)... ... August 31, 2015 , ... People ... at a greater risk for injury, potentially because they are more susceptible to ... Graduate School of Public Health analysis discovered. , The research, published online ...
(Date:8/31/2015)... ... August 31, 2015 , ... With baseball season in full ... World Series will dominate the sports world. Fans desire nothing more than to see ... final series. For children, especially those who are too young to really understand what ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... to develop skills and assess their competencies in managing challenging conversations, announced today ... at the Defense Centers of Excellence for Psychological Health and Traumatic Brain ...
Breaking Medicine News(10 mins):Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:Watching More TV as a Young Adult Predicts Obesity 2Health News:Watching More TV as a Young Adult Predicts Obesity 3Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 3Health News:New Children's Baseball Series Offers Young Fans a Way to Celebrate the World Series 2Health News:Kognito’s Glenn Albright to Present at DCoE Summit 2
(Date:8/31/2015)... 31, 2015  Dipexium Pharmaceuticals, Inc. (NASDAQ: DPRX ... and commercialization of Locilex® (pexiganan cream 0.8%), a novel, ... participate in four investor conferences in September. ... Sidoti & Company, LLC Emerging Growth Conference in ... P. Luci , President & Chief Executive Officer, will ...
(Date:8/31/2015)... 2015 Regen BioPharma, Inc. (OTCBB: RGBP) ... novel means of delivering its patented (US Patent ... tumors utilizing a clinically approved formulation as delivery ... with gene silencing therapeutics in which the gene ... whole body.  By utilizing a local delivery system, ...
(Date:8/31/2015)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ), the nation,s largest ... Chairman & CEO, and Sean Whelan , CFO, will ... Hagerman and Mr. Whelan are scheduled to participate in the ... on Wednesday, September 9, 2015 at 1:45 PM ET. ... to participate in the Robert W. Baird 2015 Healthcare Conference ...
Breaking Medicine Technology:Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 2Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 3Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Diplomat to Participate in Upcoming Investor Conferences 2
Cached News: