HOME >> MEDICINE >> NEWS
Inflammatory processes in arteriosclerosis revealed

Revolutionary new results concerning substances that play major roles in the inflammatory response have been published in the American scientific journal PNAS in two articles from Karolinska Institutet. Inflammation is important in, for example, cardiovascular disease. The results open the way for the development of new drugs both for prevention and for treatment.

Conditions and diseases that involve inflammation include severe infection, arthritis, asthma and arteriosclerosis. Certain substances, such as cytokines, are formed during the inflammation response and contribute to its various aspects. Professor Jesper Haeggstrm and his group, working in close collaboration with Professor Jan Palmblad's group, show in the first of two articles published in Proceedings of the National Academy of Sciences (2 May 2006) that several of these substances can influence the cells of the blood vessel wall such that they start to express receptors for a leukotriene, LTB4.

This enables the cells to react to LTB4 and to transmit signals that reinforce the inflammation. LTB4 is a powerfully chemotactic and immuno-modulating substance that is important for the motion of white blood cells over the walls of the blood vessel when the tissue becomes damaged and inflamed. It has previously been believed that the cells of the blood vessel wall are silent, unable to react to LTB4.

The demonstration of new factors that control the interplay between the blood vessel cells and the white blood cells that are crucial in the inflammatory process will enable the development of new drugs to be targeted against these factors. New drugs may in the long term become available for use during chronic inflammation such as arthritis, asthma and cardiovascular disease.

The second of the two articles presents the first report of a study that has been carried out in collaboration with arteriosclerosis researchers and surgeons at the Karolinska Univer
'"/>

Contact: Sara Aldn
sara.alden@ki.se
46-703-586-326
Karolinska Institutet
18-Jul-2006


Page: 1 2

Related medicine news :

1. Inflammatory system genes linked to cognitive decline after heart surgery
2. Inflammatory bowel disease doubles risk of pregnancy complications
3. Crohns & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases
4. Inflammatory biomarker helps identify progressive precancerous lesions in the lung
5. Inflammatory markers may help predict stroke risk in middle-aged people
6. Discovery of cellular processes which regulate hearts energy supply
7. Early onset of poor bone mineralization revealed in children with cystic fibrosis
8. Mechanism of black cohosh versus hot flashes revealed
9. Key to lung cancer chemo resistance revealed
10. Details of solar particles penetrating the Earths environment revealed
11. Healing honey: The sweet evidence revealed

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Inflammatory processes arteriosclerosis revealed

(Date:11/22/2014)... (PRWEB) November 22, 2014 Sandbridge ... equity investments in the consumer brand sector, acquired ... investment will be used to help fund BackJoy’s ... pipeline rollout, particularly its proprietary apparel and footwear ... join BackJoy’s Board of Directors. , BackJoy is ...
(Date:11/22/2014)... Wright & Schulte LLC reports that ... have been scheduled between October 2016 and April 2017 ... U.S. District Judge Matthew F. Kennelly, who is overseeing ... (CMO) on November 6, 2014 that outlined the trial ... documents and other activities in preparation for the bellwether ...
(Date:11/22/2014)... Nov. 21, 2014 (HealthDay News) -- Those air-blown hand ... than conventional paper towels, a new study suggests. ... the hands of volunteers in order to simulate poorly ... high-powered "jet-air" dryers or paper towels to dry their ... found higher amounts of germs around both types of ...
(Date:11/21/2014)... 21, 2014 CRN International, the radio ... industry sales professional to its award-winning team. , Leslie ... of leadership and sales experience to CRN. She will ... title of Director of Strategy and Development, reporting to ... , Heinemann will handle a wide range of territories ...
(Date:11/21/2014)... -- The cost of diabetes care in the United ... to more than $322 billion annually, a new report ... with prediabetes care, which have risen 74 percent, and ... added. In 2012, excess medical costs and lost ... every American. That total includes $244 billion in medical ...
Breaking Medicine News(10 mins):Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 2Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 4Health News:Restroom Hand Dryers Spread More Germs Than Paper Towels, Study Finds 2Health News:Radio Industry Veteran Joins CRN International’s Sales Organization in Detroit 2Health News:Cost of Diabetes Care Keeps Climbing, Report Shows 2
(Date:11/22/2014)... , Nov. 21, 2014 MEDITE Group acquired by ... months and the 3 rd quarter sales ended September ... was $448,000 for the nine months ended September 2014 and ... though our 3 rd quarter is usually a seasonable ... from July into September for many countries worldwide, we are ...
(Date:11/21/2014)... COLLEGE PARK, Md. , Nov. 21, 2014 /PRNewswire-USNewswire/ ... Engineering today will host the ceremonial groundbreaking of the ... Maryland, College Park. The new building will cultivate transformative ... human health.  Taking place at 10:00 a.m. ... building in the Paint Branch Parking Lot, adjacent to ...
(Date:11/21/2014)... MARCOS, Texas , Nov. 21, 2014  World ... hemp containing low THC, announces they are now offering ... comparable to Charlotte,s Web type strains grown in medical ... from other neurological disorders, such as Parkinson,s, MS, and ... for US laws to pass, because imported CBD Oil ...
Breaking Medicine Technology:CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3
Cached News: