HOME >> MEDICINE >> NEWS
Inflammatory system genes linked to cognitive decline after heart surgery

DURHAM, N.C. -- Variants of two genes involved in the inflammatory system appear to protect patients from suffering a decline in mental function following heart surgery.

Duke University Medical Center researchers believe their findings could help physicians identify patients at risk of suffering mental decline after heart surgery and raises the possibility that these patients could be treated with drugs that are known to dampen the inflammatory response.

Six years ago, the Duke researchers demonstrated that 42 percent of patients who underwent coronary artery bypass surgery had measurable cognitive decline five years after their procedure. Since that finding, the team has been investigating possible reasons for this decline.

The researchers selected known variations in 37 genes that previous studies had implicated in various impairments of cognitive and mental function. When they looked at more than 500 heart surgery patients and correlated cognitive decline with the patients genetic makeup, they discovered that patients with two specific variants were less likely to have problems with areas of cognitive function such as memory, attention and concentration.

While bypass surgery has saved millions of Americans with coronary artery disease, many patients and families find that cognitive decline after surgery has reduced their quality of life, said Duke cardiothoracic anesthesiologist Joseph Mathew, M.D., lead investigator of the study reported online Tuesday, May 1, in the Journal of the American College of Cardiology. The study was supported by the National Institutes of Health and the American Heart Association.

The two gene variants we found were involved in some manner with the inflammatory system, raising the possibility that therapies given during surgery aimed at the controlling the inflammatory response would be protective, Mathew said. Also, our results provide additional evidence for a genetic basis for th
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
1-May-2007


Page: 1 2 3

Related medicine news :

1. Inflammatory bowel disease doubles risk of pregnancy complications
2. Inflammatory processes in arteriosclerosis revealed
3. Crohns & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases
4. Inflammatory biomarker helps identify progressive precancerous lesions in the lung
5. Inflammatory markers may help predict stroke risk in middle-aged people
6. WPI wins $1M to develop system to locate and monitor emergency workers in buildings
7. U of M researchers assess effectiveness of computerized physician order entry system
8. STAMP system can help professionals to identify potentially violent individuals
9. New system for reporting toxicity burden of cancer treatment
10. Doctors, engineers develop new wireless system to detect esophageal reflux
11. A pioneering system allows autistic children to communicate with their environment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes ... of the facility as part of a disaster drill on October 3rd. , Apple ... Shelton City Emergency Manager, as well as the Connecticut Long Term Care Mutual ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
Breaking Medicine Technology:
Cached News: