HOME >> MEDICINE >> NEWS
Initial results help clinicians identify patients with treatment-resistant depression

Initial results of the nation's largest clinical trial for depression have helped clinicians to track "real world" patients who became symptom-free and to identify those who were resistant to the initial treatment. Participants treated in both medical and specialty mental health care settings experienced a remission of symptoms in 12 to 14 weeks during well-monitored treatment with an antidepressant medication. The study, funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH), used flexible adjustment of dosages based on quick and easy-to-use clinician ratings of symptoms and patient self-ratings of side effects.

About a third of participants reached a remission or virtual absence of symptoms during the initial phase of the study, with an additional 10 to 15 percent experiencing some improvement. Subsequent phases of the trials will help determine successful treatments for the nearly two thirds of those patients who were identified as treatment-resistant to a first medication in phase one.

The trial, known as the STAR*D study -- Sequenced Treatment Alternatives to Relieve Depression -- included 2,876 participants and was conducted over six years at a cost of $35 million. (For more information on STAR*D, go to: http://www.clinicaltrials.gov/ct/show/NCT00021528?order=1).

The medication used in this first phase of the study was the serotonin reuptake inhibitor (SSRI) citalopram (Celexa, made by Forest Pharmaceuticals), and response rates were comparable across the 23 psychiatric and 18 primary care treatment sites. John Rush, M.D., and Madhukar Trivedi, M.D., of the University of Texas Southwestern Medical Center (UTSMC), and colleagues report on the results of phase 1 of STAR*D in the January, 2005 American Journal of Psychiatry.

"The real goal of STAR*D is how best to help the 70 percent of patients for whom treatmen
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
1-Jan-2006


Page: 1 2 3 4

Related medicine news :

1. UCLA Stroke Center receives American Stroke Associations Initial Achievement Award
2. Stem cell transplantation procedure results in long-term survival for amyloidosis patients
3. GSKs Pazopanib shows positive results in patients with advanced renal cell carcinoma
4. GSKs Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
5. Targeted, oral agent Enzastaurin shows favorable results
6. Childhood obesity intervention shows promising results
7. Alpharma presents positive pharmacokinetic study results
8. UCSF brain tumor vaccine trial shows promising results
9. The eyes have it -- Autism research yields surprising results
10. ACP: Residency match results for internal medicine underscore need to redesign primary care
11. Positive results more likely from industry-funded breast cancer trials

Post Your Comments:
(Date:7/31/2014)... have learned that recent fears of invasive lionfish causing ... to control lionfish by fishing derbies and targeted fisheries ... And there,s a simple way to know for sure ... it,s been cooked. , Pacific lionfish were first reported ... have been gaining swiftly in number ever since. They,re ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Setting goals for ... on blogs on successful tips to weight loss. Fitness on ... for over 8 years, and has worked with 6000 customers ... “We have had the chance to monitor why customers start ... exercising, how long they stick to their program, whether or ...
(Date:7/31/2014)... July 31, 2014 Millions of people ... have had traumatic experiences as a child and some ... work. As a highly experienced NJ cosmetic dentist, ... anxiety during their dental procedure. To help these ... team at Champagne Smiles offer several sedation dentistry techniques. ...
(Date:7/31/2014)... Cape Coral, FL (PRWEB) July 31, 2014 ... the opportunity to take charge of their financial future. ... training for women, has opened registration for 6 upcoming ... designed by women, for women, and with input from ... (Rich Woman and It’s Rising Time) who is passionate ...
(Date:7/31/2014)... July 31, 2014 Dr. Andrew Lian-Jie ... Board of Dermatology, fellowship trained Mohs surgeon that has ... Docs. , After extensive dermatology research training at the ... Dr. Li completed his internship in internal medicine at ... of Pennsylvania in Philadelphia. Dr. Li pursued further training ...
Breaking Medicine News(10 mins):Health News:Invasive lionfish likely safe to eat after all 2Health News:Invasive lionfish likely safe to eat after all 3Health News:Fitness on the Go's Rewards Program Helps Clients Reach Their Goals 2Health News:Champagne Smiles is Thrilled to Now Offer Sedation Dentistry to their Patients 2Health News:The Independent Woman to Offer Financial Workshops in the Los Angeles Area - Developed by Women for Women 2Health News:NJ Top Docs Proudly Presents Approved Provider, Dr. Andrew Li of Warren Skin Care Center 2
(Date:7/31/2014)... , July 31, 2014 Touro University ... has been selected as the recipient of a $150,000 ... will allow the University to increase research and classroom ... creating state-of-the-art technology for the study of health sciences, ... the diverse needs and interests of our students," said ...
(Date:7/31/2014)... SAN FRANCISCO , July 31, 2014 /PRNewswire/ ... ) and Aspira Scientific ( Milpitas, California ... joint venture to develop and commercialize new fluorination ... biologically active molecules has benefited from the use ... metabolism, and combine lipophilicity with polarity to improve ...
(Date:7/31/2014)... ANTWERP, Belgium and LONDON , July ... Organization (CRO) and services provider for the medical industries, announced today ... The United Kingdom has one ... valued at USD 8.9 billion in 2012 and it is projected ... was estimated at USD 234 billion in 2012, equal to 9.5% ...
Breaking Medicine Technology:Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2genae Opens Offices in London 2
Cached News: