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Insulin levels and resistance linked to risk of pancreatic cancer

resistance tended to show positive dose-response associations with pancreatic cancer. Biochemically defined diabetes mellitus and insulin concentration in the highest quartile demonstrated significant 2-fold increased risks. There were significant interactions between quartile-categorized glucose, insulin, and insulin resistance and pancreatic cancer by follow-up time, such that risks were greater among the cases that occurred with longer follow-up time.

"In conclusion, our results support the hypothesis that higher insulin concentrations and insulin resistance may be a mechanism that explains the associations between diabetes mellitus, higher glucose concentration, and pancreatic cancer observed in previous studies. Although based solely on male smokers, our findings for glucose and biochemical-defined diabetes mellitus are consistent with previous studies conducted in diverse populations that have included women and nonsmokers," the authors write.

"The associations for insulin and insulin resistance reported herein require confirmation and along with observations of other studies could potentially have important implications for nutrition and treatment-related cancer preventive strategies that modify or interfere with the insulin resistance pathway to help decrease the burden from this devastating disease. Lifestyle changes to decrease glucose and insulin concentrations through weight reduction, increasing physical activity, and diet such as decreasing saturated fat intake, and identification of other modifiable factors that may contribute to higher glucose and insulin concentrations could possibly impact pancreatic cancer development, as well as other cancer and chronic disease," the researchers write.


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JAMA and Archives Journals
13-Dec-2005


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