HOME >> MEDICINE >> NEWS
Interferon with ribavirin is safe and effective for children with chronic Hepatitis C

Nearly half of 118 children with chronic Hepatitis C virus (HCV) treated with a combination of interferon-alpha-2b and an optimized dose of ribavirin achieved sustained viral response, and side effects were generally mild. These results are reported in the November 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD).

Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

HCV is usually asymptomatic in children though it can lead to serious liver damage. Treatment with interferon is standard and induces lasting remission in more than a third of infected children. The addition of ribavirin to treatment with interferon has been shown to markedly improve outcomes for adults with HCV, but the combination has not been extensively studied in children. Led by Regino Gonzlez-Peralta, M.D. of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition at the University of Florida, researchers addressed combination therapy for children with a twofold program.

The first part searched for the optimal dose of ribavirin for children with HCV while testing the drug's safety and efficacy. Fifty-six children, ages five to 16, were randomly assigned to take interferon along with ribavirin in varying doses for 48 weeks. They were evaluated for efficacy and side effects at regular intervals, and followed-up for an additional 24 weeks. By the end of the follow-up period, 35 percent of children taking 8 mg/kg/day of ribavirin, 37 percent taking 12 mg/kg/day, and 47 percent of 15/mg/kg/day had undetectable levels of HCV in their blood. Side effects were similar among all doses. Based on this data, the researchers selected the dosage 15 mg/kg/day for further study.

In all, 118 children with HCV received the optimized treatment
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
1-Nov-2005


Page: 1 2

Related medicine news :

1. Interferon-treated hepatitis C patients likely to experience retinopathy
2. Hepatitis C responds best to combo of ribavirin and interferon, study concludes
3. New treatment effective in counteracting cocaine-induced symptoms
4. Osteoporosis screening and treatment may be cost-effective for selected older men
5. Study shows radiofrequency ablation highly effective in treating kidney tumors
6. New study examines effectiveness of tailored health messages
7. Scaling up HIV prevention programs is cost effective
8. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
9. U of M researchers assess effectiveness of computerized physician order entry system
10. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
11. Meningitis: effectiveness of preventive vaccination demonstrated

Post Your Comments:
(Date:3/28/2015)... FL (PRWEB) March 28, 2015 ... conditions coverage is made available to all visitors who ... effective immediately. All members are encouraged to purchase the ... to avoid lack of proper coverage for pre-existing medical ... from one or two medical conditions with serious consequences ...
(Date:3/28/2015)... Pitching speed, player’s height, and pitching for ... elbow injuries, according to new research released today at the ... Day. , “Our findings indicate that a 10 inch increase ... of a history of injury, a 10 mile per hour ... of a history of injury, and playing for more than ...
(Date:3/28/2015)... 2015 Delaying rotator cuff surgery on ... to research presented today at the American Orthopaedic Society ... “Our study compared results for 170 patients who received ... glenohumeral joint capsule release procedure to relieve stiffness at ... lead author from St. George Hospital in Sydney, Australia. ...
(Date:3/28/2015)... Andrew Hawley of Vintage Rock Posters Inc., has ... The Who and the Doors played together at the Singer ... to Hawley, “The Who toured the United States heavily from ... Perhaps the most famous Who poster was a poster created ... on August 2, 1968 at the Singer Bowl in Flushing, ...
(Date:3/28/2015)... 2015 Healthpointe’s otolaryngologists, medical practitioners who ... disorders, are now offering a wide variety of ... is characterized by the presence of phantom sounds or ... tinnitus is a prevalent symptom that can arise due ... non-fatal, tinnitus can impede a person’s quality of life. ...
Breaking Medicine News(10 mins):Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 2Health News:India Network Health Insurance Today Announces New Eligibility Criteria for Pre-existing Condition Health Insurance Coverage for Visitors to the United States 3Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2
(Date:3/27/2015)... 27, 2015  Holographic Optical Technologies of ... holographic medical imaging, is entering the world of consumer ... on April 20 th , 2015, the campaign will ... 8-inch and 22-inch displays will allow consumers to view ... time. In addition to the two displays, the company ...
(Date:3/27/2015)... DIEGO , March 27, 2015   ... company, today announced new data showing that, compared ... TM technology provided highly equivalent interpretations of ... disease, and did so in a fraction of ... the way for more comprehensive genetic analysis in ...
(Date:3/27/2015)... 2015 XRpro Sciences, Inc., a provider ... development services which features high throughput transporter and ... financial results for the year ended December 31, ... of XRpro Sciences commented, "We have completed a ... stage to commercial stage in large part by ...
Breaking Medicine Technology:Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4
Cached News: