HOME >> MEDICINE >> NEWS
International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), today announced that enrollment into a large international HIV/AIDS trial comparing continuous antiretroviral therapy with episodic drug treatment guided by levels of CD4+ cells has been stopped. Enrollment was stopped because those patients receiving episodic therapy had twice the risk of disease progression (the development of clinical AIDS or death), the major outcome of the study.

NIAID made the decision to halt enrollment in collaboration with the study's Executive Committee and following a recommendation received from an independent Data and Safety Monitoring Board (DSMB). The DSMB, charged with regularly evaluating data and safety issues during the multi-year trial, conducted a review of the interim study data in early January.

The trial, known as Strategies for Management of Anti-Retroviral Therapy, or SMART, was designed to determine which of two different HIV treatment strategies would result in greater overall clinical benefit. HIV-positive volunteers were assigned at random to either a viral suppression strategy, in which antiretroviral therapy (ART) was taken on an ongoing basis to suppress HIV viral load; or a drug conservation strategy, in which ART was started only when the levels of key immune cells, called CD4+ cells, dropped below 250 cells per cubic millimeter (mm3). Volunteers in the drug conservation group were taken off ART--with the aims of reducing drug side effects and preserving treatment options--whenever their CD4+ cells were above 350 cells/mm3. (For more details see http://www.smart-trial.org).

The trial involved an international collaboration of 318 clinical sites in 33 countries. It began enrollment in January 2002 and had successfully recruited more than 90 percent of its target of 6,000 participants: as of January 11, 2006, when enrollment was stopped,
'"/>

Contact: Laurie K. Doepel
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
18-Jan-2006


Page: 1 2 3 4

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Africa: International volunteer impact small, but significant
3. International Workshop on Cities, Science and Sustainability
4. International journal group updates guidelines on registration of clinical trials
5. International studies show high efficacy for HPV vaccine
6. Poorer countries could struggle to implement new International Health Regulations
7. Chinese space agency joins the International Charter Space and Major Disasters
8. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
9. International cooperation boosts EarthCARE
10. International award
11. International Best Cases Competition returns to Vancouver

Post Your Comments:
(Date:4/1/2015)... This year for Oral Cancer Awareness Month, Herald ... an Open House to offer complimentary oral cancer screenings on ... An appointment is required and can be secured by calling ... In addition, Herald Square Dental and The Denture Center are ... April at the reduced cost of $39 (regularly $78). Half ...
(Date:4/1/2015)... The panel session will look at the need for ... program that can grow in a privacy-friendly manner, thus ... line. This topic has taken on even greater relevance ... dongles aren’t as secure as the automobile industry thought ... Progressive’s Snapshot dongles contained very significant security flaws, which ...
(Date:4/1/2015)... Orlando, FL (PRWEB) April 01, 2015 ... dedicated to providing the latest information on the top ... attempt to set the Guinness World Records title for ... as part of the 1st annual Baby Bellies & ... at 10am, and the Guinness World Record will commence ...
(Date:4/1/2015)... 2015 BioPlus Specialty Pharmacy ... has released a new app to keep health care ... chronic hepatitis C virus (HCV) infection. This ‘HCV Treatment ... from the American Association for the Study of Liver ... new direct-acting oral medications to treat HCV have been ...
(Date:4/1/2015)... Dr. Daniel C. Stewart ... to discuss the benefits of the LANAP® treatment over ... periodontal disease. People who live in Howard County, and ... can now visit Dr. Stewart, a Maryland dentist, for ... the LANAP® protocol, which is a laser gum surgery ...
Breaking Medicine News(10 mins):Health News:Herald Square Dental Celebrates Oral Cancer Awareness Month 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 3Health News:Baby Bellies & Beyond Attempts To Break Guinness World Records For “Mommy Moments” Largest Gathering Of Pregnant Women April 19 Outside Florida Hotel & Conference Center 2Health News:Baby Bellies & Beyond Attempts To Break Guinness World Records For “Mommy Moments” Largest Gathering Of Pregnant Women April 19 Outside Florida Hotel & Conference Center 3Health News:BioPlus Specialty Pharmacy Releases ‘HCV Treatment Path’ App for Hepatitis C Providers 2Health News:Dr. Daniel C. Stewart Offers Columbia Area Residents an Informational Seminar in April About Less Invasive Gum Disease Treatment Now Available at Smile Savers Dentistry 2Health News:Dr. Daniel C. Stewart Offers Columbia Area Residents an Informational Seminar in April About Less Invasive Gum Disease Treatment Now Available at Smile Savers Dentistry 3
(Date:4/1/2015)... 2015 Trinity Biotech plc (Nasdaq: ... diagnostic products for the point-of-care and clinical laboratory ... its wholly-owned subsidiary (the "Issuer"), intends to offer, ... aggregate principal amount of Exchangeable Senior Notes due ... buyers pursuant to Rule 144A under the Securities ...
(Date:4/1/2015)... , April 1, 2015  Hologic, Inc. (NASDAQ: ... of the 2.00% Convertible Exchange Senior Notes due 2037 ... Wilmington Trust Company, the trustee, paying agent and conversion ... convert the notes.  This conversion right is subject to ... dated as of December 10, 2007, as supplemented by ...
(Date:4/1/2015)... and ASPEN, Colo. , April ... with the Chris Klug Foundation (CKF), is pleased to sponsor ... being accepted for the award, which will recognize two ... life, whether it is a career accomplishment, participation in ... life with family and loved ones. ...
Breaking Medicine Technology:Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 2Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 3Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 4Hologic Delivers Notice that Holders of 2.00% Convertible Exchange Senior Notes Due 2037 are Eligible to Convert 2Astellas Teams Up with The Chris Klug Foundation on the Bounce Back Award to Recognize Extraordinary Transplant Recipients 2Astellas Teams Up with The Chris Klug Foundation on the Bounce Back Award to Recognize Extraordinary Transplant Recipients 3
Cached News: