HOME >> MEDICINE >> NEWS
Iron particles and MRI could replace biopsies to track stem cell therapy and deploy stents

one. Measurements of the heart's pumping function also improved in the same region.

"Our results show that MRI tracking of mesenchymal stem cells can be used - as a replacement to surgical biopsy - to verify that such cell-based therapies reached damaged areas of the heart and were able to effect repair and improve heart function," says study senior co-investigator Jeff Bulte, Ph.D., an associate professor in radiology at Hopkins who developed the labeling method.

In other experiments in rabbits and dogs, the researchers successfully used the IRON method, which was developed at Hopkins, to track relatively small numbers of stem cells in the body and to deploy a metallic stent, a mesh-like device that opens blood vessels narrowed by fat and calcium buildup.

"Physicians must confirm that potential therapies, whether they are cell based or involve devices, are delivered as planned to the targeted organ or other part of the body," says lead investigator Wesley Gilson, Ph.D., a postdoctoral research fellow at Hopkins. Gilson's work was recognized at the heart meeting, where he was a finalist for the prestigious Melvin Judkins Young Clinical Investigator Award.

With IRON, conventional MRI technology is adapted to reveal images of ever smaller numbers of cells, avoiding image artifacts that mimic the appearance of iron-labeled cells.

Scientists were able to visualize metal objects, which previously appeared as dark spots on the MRI screen, by suppressing the vast majority of the conventional image produced from water molecules (or so-called on-resonant signal), the most common substance in the body.

By eliminating the water-based signals, the scientists were left only with the signal produced from metal objects (or so-called off-resonant signal), such as prosthetic screws, metal clips or stents.

In effect, Gilson says, the machine was made sensitive to iron molecules in the formerly unseen region. "We effect
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
2-Dec-2005


Page: 1 2 3 4

Related medicine news :

1. Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
2. Impact of a chemical component of diesel exhaust particles
3. Nanoparticles can track cells deep within living organisms
4. U-M researchers use nanoparticles to target brain cancer
5. Details of solar particles penetrating the Earths environment revealed
6. Electric jolt triggers release of biomolecules, nanoparticles
7. NYU researchers decorate virus particles, showing potential to enhance MRI capabilities
8. Beyond the hype and the scare stories, how safe are nanoparticles?
9. MIT nanoparticles may help detect, treat tumors
10. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
11. Michigan State research sheds new light on health dangers of nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... ... ) announced their partnership to prep patients for colonoscopy at the HyGIeaCare® Center ... in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, cleared by ...
(Date:3/24/2017)... ... 2017 , ... “Vintage and Harvest A Cultivation of Christian Love” is the ... in North Carolina with his wife, Anna Marie. He and his wife are the ... is also the author of “Shadow and Substance.” , “Love, the agape kind, is ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... The physicians ... location in the greater Houston Area. The new location is located at 2255 E. ... Hospital in Springwoods Village. This newest location will provide patients living in the north ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... The MBI “Hall of Fame” recognizes the ... acts have had a significant impact on the careers of all others involved. ... Inc. was inducted into the MBI’s Hall of Fame. The induction took place during ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... Disease Management Accreditation from the NCQA. The accreditation covers StayWell’s asthma, coronary artery ... Accredited status is granted to organizations that have excellent programs for the delivery ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017  Zymo ... company, and Hamilton Robotics, Inc., who designs, ... an ongoing collaboration that teams Zymo Research,s ... RNA and DNA extraction products with Hamilton,s ... created optimized methods for microbiomics and RNA ...
(Date:3/24/2017)... NEW YORK , March 24, 2017 /PRNewswire/ ...  a leading organization within medical affairs in the ... as the chair of a newly formed ... additional board members to form the first ever ... For more information about the ACMA, ...
(Date:3/24/2017)... , Mar. 24, 2017 Research and Markets has ... Analysis, 2016" report to their offering. ... The IPF pipeline is very strong with a total ... & Co., Inc., Biogen and Sanofi are involved in the development of ... which one is in Phase III stage, 15 are in Phase II ...
Breaking Medicine Technology:
Cached News: