HOME >> MEDICINE >> NEWS
Iron particles and MRI could replace biopsies to track stem cell therapy and deploy stents

one. Measurements of the heart's pumping function also improved in the same region.

"Our results show that MRI tracking of mesenchymal stem cells can be used - as a replacement to surgical biopsy - to verify that such cell-based therapies reached damaged areas of the heart and were able to effect repair and improve heart function," says study senior co-investigator Jeff Bulte, Ph.D., an associate professor in radiology at Hopkins who developed the labeling method.

In other experiments in rabbits and dogs, the researchers successfully used the IRON method, which was developed at Hopkins, to track relatively small numbers of stem cells in the body and to deploy a metallic stent, a mesh-like device that opens blood vessels narrowed by fat and calcium buildup.

"Physicians must confirm that potential therapies, whether they are cell based or involve devices, are delivered as planned to the targeted organ or other part of the body," says lead investigator Wesley Gilson, Ph.D., a postdoctoral research fellow at Hopkins. Gilson's work was recognized at the heart meeting, where he was a finalist for the prestigious Melvin Judkins Young Clinical Investigator Award.

With IRON, conventional MRI technology is adapted to reveal images of ever smaller numbers of cells, avoiding image artifacts that mimic the appearance of iron-labeled cells.

Scientists were able to visualize metal objects, which previously appeared as dark spots on the MRI screen, by suppressing the vast majority of the conventional image produced from water molecules (or so-called on-resonant signal), the most common substance in the body.

By eliminating the water-based signals, the scientists were left only with the signal produced from metal objects (or so-called off-resonant signal), such as prosthetic screws, metal clips or stents.

In effect, Gilson says, the machine was made sensitive to iron molecules in the formerly unseen region. "We effect
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
2-Dec-2005


Page: 1 2 3 4

Related medicine news :

1. Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
2. Impact of a chemical component of diesel exhaust particles
3. Nanoparticles can track cells deep within living organisms
4. U-M researchers use nanoparticles to target brain cancer
5. Details of solar particles penetrating the Earths environment revealed
6. Electric jolt triggers release of biomolecules, nanoparticles
7. NYU researchers decorate virus particles, showing potential to enhance MRI capabilities
8. Beyond the hype and the scare stories, how safe are nanoparticles?
9. MIT nanoparticles may help detect, treat tumors
10. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
11. Michigan State research sheds new light on health dangers of nanoparticles

Post Your Comments:
(Date:1/22/2015)... Liberty University has received accreditation for its resident ... Council for Accreditation of Counseling & Related Educational Programs ... for Counseling & Family Studies , is under the leadership ... School of Behavioral Sciences. Prior to the formation of the ...
(Date:1/22/2015)... Glendale, AZ (PRWEB) January 22, 2015 Padre ... a long supporter of Pro Player Health Alliance ... with Padre Murphy's in getting everyone, including NFL greats, treated ... one of the leading groups supporting the cause in the ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
(Date:1/22/2015)... La Jolla, Calif. (PRWEB) January 22, 2015 ... and Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen ... (CHI) for their leadership in advancing biotechnology, biomedical ... Mitchell, Bonilla and Olsen each received the “2014 ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
(Date:1/22/2015)... Inc. (NYSE: RMD ) today announced results for ... was $423.0 million, a 10 percent increase compared to the ... a constant currency basis). Net income was $91.2 million, an ... 31, 2013. Diluted earnings per share for the quarter were ...
(Date:1/22/2015)... , Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: ... the first member of the new Simple Plex platform ... This launch represents the re-branding of the previously acquired ... Plex platform is a transformative immunoassay technology which integrates ...
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ) has announced the ... Product, Application, Technology, End User - Global Forecast to ... The infectious disease diagnostics market is expected to grow ... 2019 from $12,422.8 million in 2014. Increase in governmental ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
Cached News: