HOME >> MEDICINE >> NEWS
Is most published research really false?

In 2005, PLoS Medicine published an essay by John Ioannidis, called "Why most published research findings are false," that has been downloaded over 100,000 times and that was called "an instant cult classic" in a Boston Globe op-ed of July 27 2006 (http://www.boston.com/news/science/articles/2006/07/27/science_and_shams/). This week, PLoS Medicine revisits the essay, publishing two articles by researchers that move the debate in two new directions.

In his 2005 essay (freely available at http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0020124) , Dr Ioannidis wrote: "Published research findings are sometimes refuted by subsequent evidence, with ensuing confusion and disappointment." He argued that there is increasing concern that in modern research, false findings may be the majority or even the vast majority of published research claims, and went on to try and prove that most claimed research findings are false.

However, in this week's PLoS Medicine, Ramal Moonesinghe (US Centers for Disease Control and Prevention) and colleagues demonstrate that the likelihood of a published research result being true increases when that finding has been repeatedly replicated in multiple studies.

"As part of the scientific enterprise," say the authors, "we know that replicationthe performance of another study statistically confirming the same hypothesisis the cornerstone of science and replication of findings is very important before any causal inference can be drawn." While the importance of replication was acknowledged by Dr Ioannidis, say Dr Moonesinghe and colleagues, he did not show that the likelihood of a statistically significant research finding being true increases when that finding has been replicated in many studies.

The authors say that their new demonstration "should be encouraging news to researc
'"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
26-Feb-2007


Page: 1 2

Related medicine news :

1. EVEREST data on use of tolvaptan published in JAMA and featured at ACC
2. Bayer and Onyx announce pivotal Nexavar kidney cancer study published in NEJM
3. In stroke, negative studies less likely to get published
4. Landmark study on diabetic foot infection published
5. New international standards for tuberculosis care published
6. Research published in the NEJM challenges 30-year-old standard of care for lupus patients
7. Newly published summer camp health guideline advises parents, camp directors
8. Child sex abuse policy recommendations published in Science magazine
9. 1 of 2 pediatric kidney disease research centers in world established
10. Stanford researchers find culprit in aging muscles that heal poorly
11. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/15/2019)... ... ... Ophthalmic Consultants of Long Island (OCLI), a Spectrum Vision Partners managed practice, ... East Sunrise Highway, Suite 400, Valley Stream, NY 11581. The new location will enable ... D’Aversa, MD, “After serving the Valley Stream community for over 15 years, we are ...
(Date:1/14/2019)... , ... January 14, 2019 , ... ... supplements, household and personal-care products with a presence worldwide, today announced that it ... 2018. Measured year-over-year, Modere sales grew by double-digits in North America, by more ...
(Date:1/14/2019)... ... 2019 , ... Docs Proudly Presents All Reviewed & Approved Living Well Providers of 2019. , Acupuncture, ... Dr. Edward Izrailov - Maplewood , Dr. Joanna Jodar - Somerset , ... Robert Lenahan - Point Pleasant , Dr. Robert J. Reinhardt - Pequannock , ...
(Date:1/13/2019)... ... ... IL Top Docs Include: , ANESTHESIOLOGY, Dr. Adam Block , ... Dr. Marcie Claybon , NEPHROLOGY, Dr. Naila Ahmed ... Dr. Aarathi Cholkeri-Singh , PEDIATRICS, Dr. ...
(Date:1/11/2019)... ... January 11, 2019 , ... Women’s Excellence Obstetrics and ... Dr. Jonathan Zaidan, President of Women’s Excellence, will co-host WJR’s "Health Women Show" ... each month at 7pm. , "We are excited to partner with a longstanding, ...
Breaking Medicine News(10 mins):
(Date:1/20/2019)... YORK (PRWEB) , ... January 18, 2019 , ... ... entered into two exclusive licenses to develop the drug pentosan polysulfate sodium for ... and ReqMed Company, Ltd. of Japan. , MPS is a group ...
(Date:1/20/2019)... ... January 19, 2019 , ... California firefighter Trent Knuckles is ... Hard Sweepstakes. He won one of three prize packages that included a check for ... of 5.11 tactical gear that included a carry bag, backpack, RAID Glasses, flashlight, hats ...
(Date:1/15/2019)... ... January 15, 2019 , ... WebBuy, the nation’s first, fully integrated online car-buying ... eager to reach a demographic of customers they’ve never served before. , WebBuy’s digital-retailing ... and complete the purchase on the dealer’s website. Buyers lock in a price, get ...
Breaking Medicine Technology:
Cached News: