In an accompanying commentary, Jay K. Kolls from the Children's Hospital of Pittsburgh in Pennsylvania, puts the work by Biswal and colleagues into the context of a pressing public health need, when he informs us that "despite decades of advances in antibiotic treatment, sepsis remains an elusive killer, with over 750,000 cases per year in North America, with 40-50% mortality in adults." In addition, he notes that these studies "confirm the critical role of the cellular redox state in regulating the immune system and support the contention that antioxidants are critical in regulating the cellular response to external stressors."
TITLE: Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
AUTHOR CONTACT: Shyam Biswal
Johns Hopkins University, Baltimore, Maryland, USA
Phone: (410) 955-4728; Fax: (410) 955-0116; E-mail: sbiswal@jhsph.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=25790
ACCOMPANYING COMMENTARY:
TITLE: Oxidative stress in sepsis: a redox redux
AUTHOR CONTACT: Jay K. Kolls
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Phone: (412) 648-7457; Fax: (412) 692-6645; E-mail: jay.kolls@chp.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=28111
IMMUNOLOGY
Transforming T cells into tumors takes time and tax
Infection with human T cell leukemia virus type 1 (HTLV-1) leads to an aggressive disease called adult T cell leukemia/lymphoma (ATLL) or a related condition called HAM/TSP, following an asymptomatic period of 30 years. HTLV-1 infects
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Apr-2006