In an accompanying commentary, Stephen B. Liggett from the University of Maryland School of Medicine in Baltimore notes that, "although previous studies have suggested that approaches that decrease this signaling might be protective against the development of heart failure or be beneficial in treatment, the data obtained from this study of alpha1A/B knockout mice provide support for the potential deleterious effects of alpha1-adrenergic blockade."
TITLE: alpha1-Adrenergic receptors prevent a maladaptive cardiac response to pressure overload
AUTHOR CONTACT: Paul C. Simpson
San Francisco VA Medical Center, San Francisco, California, USA
Phone: (415) 221-4810 ext. 3200; Fax: (415) 379-5570; E-mail: paul.simpson@ucsf.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=22811
ACCOMPANYING COMMENTARY:
TITLE: Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify
AUTHOR CONTACT: Stephen B. Liggett
University of Maryland School of Medicine, Baltimore, Maryland, USA
Phone: (410) 706-6256; Fax: (410) 706-6262; E-mail: sligg001@umaryland.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=28234
CARDIOLOGY
The heart teams with the kidney to control blood pressure
To control blood pressure, the kidney has evolved a m
'"/>
Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Apr-2006