JCI Table of Contents, Apr...( st necessary in the relatively narrow t...),Health

TITLE: In humans, early cortisol biosynthesis provides a mechanism to safeguard sexual development

AUTHOR CONTACT: Neil A. Hanley
Southampton General Hospital, Southampton, United Kingdom

Phone: 44-23-8079-5040; Fax: 44-23-8079-4264; E-mail:N.A.Hanley@soton.ac.uk

View the PDF of this article at: https://www.the-jci.org/article.php?id=25091

ACCOMPANYING COMMENTARY:

TITLE: Ontogeny of adrenal steroid biosynthesis: why girls will be girls

AUTHOR CONTACT: Perrin C. White
UT Southwestern Medical Center, Dallas, Texas, USA

Phone: (214) 648-3501; Fax: (214) 648-9772; E-mail: Perrin.white@utsouthwestern.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=28296

AUTOIMMUNITY

Antibodies in arthritis: reacting to self

Rheumatoid arthritis (RA) is a painful inflammatory disorder of the joints. Now, in a study appearing in the April issue of the Journal of Clinical Investigation, researcher V. Michael Holers and colleagues at the University of Colorado Health Sciences Center in Denver examine the pathogenic role of antibodies known as "anti-CCP antibodies," which react against joint proteins that have been "citrullinated" or modified by the addition of a citrulline peptide. The researchers induced arthritis in mice by injecting them with a collagen protein that had been isolated from cows. This procedure resulted not only in the onset of RA in the mice, but also was associated with the production of both anti-collagen and anti-CCP antibodies in the blood. The authors found t
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Apr-2006