HOME >> MEDICINE >> NEWS
JCI table of contents -- May 17, 2007

EDITOR'S PICK

Role of TRPM8 in the development of prostate cancer

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific marker and therapeutic target in prostate cancer. However, the regulation of and changes in TRPM8 during prostate cancer progression have remained unclear.

In normal prostate epithelium, cells coexist in many stages of development/differentiation progressing from stem cells to mature luminal cells. Disrupted or dysregulated differentiation and proliferation are major causes of cancer. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Natalia Prevarskaya from Universit des Sciences et Technologies de Lille, France, show that only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells possessed higher PM-TRPM8 levels than normal cells. However, endoplasmic reticulum TRPM8 (ER-TRPM8) retained its function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor.

TITLE: Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

AUTHOR CONTACT:

Natalia Prevarskaya

Universit des Sciences et Technologies d
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-May-2007


Page: 1 2 3 4 5 6 7

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents: May 10, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents May

(Date:12/15/2014)... HealthDay Reporter FRIDAY, Dec. ... reassure the millions of American women who have migraine: The ... "There is no association between migraine and breast cancer risk," ... at Harvard Medical School. "There is no positive association, so ... protective effect either." About 18 percent of American women ...
(Date:12/15/2014)... The increase in prevalence of disabling hearing loss in the ... contributing to the growth in the global audiological market. Devices ... loss and balance disorders are known as audiological devices. An ... amplifier. The global market is expected to grow at a ... 2014 to 2019. Some of the factors which are driving ...
(Date:12/15/2014)... Austin, TX (PRWEB) December 15, 2014 ... with offices in 26 countries in North and South ... begun accepting responses from industry participants for its 2015 ... survey in order to identify upcoming business and market ... industry respondents. , The survey targets areas including:, ...
(Date:12/15/2014)... CA (PRWEB) December 15, 2014 At ... the organizations AutismOne and Focus Autism ... enlighten attendees with research on the effects of toxins ... testing and intervention information. , Luminaries such as ... researchers from abroad with esteemed, credentialed colleagues of the ...
(Date:12/15/2014)... December 15, 2014 Kenmode Precision Metal ... firm as Director of Quality Assurance. He brings ... systems, processes and certifications for manufacturers in the U.S. ... of Corporate Quality Manager at Sonoco Products Company in ... NetCom, Inc., and Quality Assurance Manager for Prince Industries, ...
Breaking Medicine News(10 mins):Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 3Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 4Health News:Emergo’s Annual Survey Assessing the State of the Medical Device Industry Now Open 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3Health News:Kenmode Precision Metal Stamping Appoints Abid Rashid as Director of Quality Assurance 2
(Date:12/13/2014)... China , Dec 12, 2014 Mindray ... a leading developer, manufacturer and marketer of medical devices ... general meeting of shareholders held in Hong ... At the meeting, Mindray shareholders voted to re-elect incumbent ... a three-year term. Mindray,s shareholders did not re-elect ...
(Date:12/13/2014)... and INDIANAPOLIS , Dec. 12, ... and Chip Ganassi Racing Teams (CGRT), today announced a multi-year ... the primary sponsor of the No. 83 Novo Nordisk Chip ... the Verizon IndyCar Series. Kimball, 29, from ... only licensed driver with diabetes in the history of INDYCAR ...
(Date:12/13/2014)... 2014 Research and Markets ( ... "China Chemical Pharmaceutical Industry Report, 2013-2016"  report ... http://photos.prnewswire.com/prnh/20130307/600769 Chemical ... active pharmaceutical ingredient (API), and the gross margin ... than that of the API over the same ...
Breaking Medicine Technology:Mindray Announced Shareholder Resolutions Post 2014 Annual General Meeting 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7China Chemical Pharmaceutical Industry Report, 2013-2016 2China Chemical Pharmaceutical Industry Report, 2013-2016 3
Cached News: