HOME >> MEDICINE >> NEWS
JCI table of contents -- May 17, 2007

EDITOR'S PICK

Role of TRPM8 in the development of prostate cancer

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific marker and therapeutic target in prostate cancer. However, the regulation of and changes in TRPM8 during prostate cancer progression have remained unclear.

In normal prostate epithelium, cells coexist in many stages of development/differentiation progressing from stem cells to mature luminal cells. Disrupted or dysregulated differentiation and proliferation are major causes of cancer. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Natalia Prevarskaya from Universit des Sciences et Technologies de Lille, France, show that only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells possessed higher PM-TRPM8 levels than normal cells. However, endoplasmic reticulum TRPM8 (ER-TRPM8) retained its function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor.

TITLE: Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

AUTHOR CONTACT:

Natalia Prevarskaya

Universit des Sciences et Technologies d
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-May-2007


Page: 1 2 3 4 5 6 7

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents: May 10, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents May

(Date:11/26/2014)... HealthDay Reporter WEDNESDAY, Nov. 26, 2014 ... understand what they,re saying, a new study suggests they are ... way. Past research has shown that dogs respond to ... and the emotional tone, said study author Victoria Ratcliffe. ... canine brain, according to Ratcliffe, a Ph.D. candidate at the ...
(Date:11/26/2014)... Steven Reinberg HealthDay Reporter ... adults are smoking cigarettes than ever, health officials said. ... about 21 percent in 2005 to 18 percent in 2013. ... million to 42.1 million, despite the increasing population, according to ... However,"we still have a long way to go, and ...
(Date:11/26/2014)... 2014 The Maryland Economic Development ... tenth annual MEDA Awards, which, sponsored by Miles ... Maryland. “The MEDA Awards recognize the individuals, programs ... state. We encourage our members to nominate the ... positive economic impact in the state of Maryland,” ...
(Date:11/26/2014)... November 26, 2014 Increasing demand ... include image guided surgeries has paved way for ... Rising incidence of various types of cancers and ... increase in demand for these owing to their ... contrast media injectors market can also be attributed ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 German scientists ... materials science can cause mesothelioma that looks and acts ... a new article on the research. Click here ... Fraunhofer Institute for Toxicology and Experimental Medicine in Hannover ... While all of the rats eventually developed mesothelioma ...
Breaking Medicine News(10 mins):Health News:Your Dog Really Is Listening to You 2Health News:Your Dog Really Is Listening to You 3Health News:U.S. Adult Smoking Rate Drops to New Low: CDC 2Health News:U.S. Adult Smoking Rate Drops to New Low: CDC 3Health News:Maryland Economic Development Association Seeking Submissions for 2015 Awards 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2
(Date:11/26/2014)... November 26, 2014 Investor-Edge has initiated ... VVUS ), Horizon Pharma PLC (NASDAQ: HZNP ), ... (NYSE: JNJ ), and Theravance Inc. (NASDAQ: ... be accessed at: http://investor-edge.com/register . On Tuesday, ... 0.07%, the Dow Jones Industrial Average edged 0.02% lower, to ...
(Date:11/26/2014)... Pa. , Nov. 26, 2014 ... to the development of innovative transdermal synthetic cannabinoid treatments, ... Piper Jaffray 26th Annual Healthcare Conference 2014. The conference ... New York Palace in New York ... will present at 4:50 pm on Tuesday, December 2. ...
(Date:11/26/2014)... and LONDON , Nov. ... market intelligence, MarketResearch.com is pleased to announce the distribution ... Consultancy focusing on the active pharmaceutical ingredient (API) market. ... http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In IQ4I,s newest ... Forecast to 2020 , IQ4I analysts ...
Breaking Medicine Technology:Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3
Cached News: