HOME >> MEDICINE >> NEWS
JCI table of contents -- May 17, 2007

EDITOR'S PICK

Role of TRPM8 in the development of prostate cancer

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific marker and therapeutic target in prostate cancer. However, the regulation of and changes in TRPM8 during prostate cancer progression have remained unclear.

In normal prostate epithelium, cells coexist in many stages of development/differentiation progressing from stem cells to mature luminal cells. Disrupted or dysregulated differentiation and proliferation are major causes of cancer. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Natalia Prevarskaya from Universit des Sciences et Technologies de Lille, France, show that only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells possessed higher PM-TRPM8 levels than normal cells. However, endoplasmic reticulum TRPM8 (ER-TRPM8) retained its function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor.

TITLE: Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

AUTHOR CONTACT:

Natalia Prevarskaya

Universit des Sciences et Technologies d
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-May-2007


Page: 1 2 3 4 5 6 7

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents: May 10, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... Registered nurses, licensed practical nurses and nursing aides ... Time to Act, Time to Heal” on Thursday, February 25 from 9:00 to 11:00 ... is Vishal Chedda, president of ANSA Consultants, who will discuss clinical best practices throughout ...
(Date:2/11/2016)... Tampa, FL (PRWEB) , ... February 11, 2016 , ... ... Tampa Bay Lightning take on the St. Louis Blues at the Amalie Arena. The ... only portable, inflatable, walk-through heart exhibit, the MEGA Heart, prior to the game. The ...
(Date:2/11/2016)... Nashville, TN (PRWEB) , ... February 11, 2016 , ... ... commercial cleaning business to a new market, and it’s the buildings of Nashville that ... much that when I needed to relocate to Nashville, there was no question that ...
(Date:2/11/2016)... ... February 11, 2016 , ... The Chartis Group, a national ... firms in the “2015/2016 Best in KLAS: Software and Services” report in two ... research and insights firm on a global mission to improve healthcare delivery by ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... will discuss how to improve care by making data on heart procedures public ... The Summit on Transparency and Public Reporting of Pediatric and Congenital Heart Disease ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Fla. , Feb. 11, 2016 ... ) company providing high-quality specialty pharmacy care for ... announced today it has achieved full Specialty Pharmacy ... accrediting organization dedicated to promoting health care quality ... --> --> The URAC accreditation ...
(Date:2/11/2016)... 11, 2016  Aytu BioScience, Inc. (OTCQX: AYTU), a ... and related conditions, announced today that the Company will ... of 2016 on Tuesday, February 16, 2016, at 4:30 ... provide an overview of its business and growth strategy, ... ended December 31, 2015. --> ...
(Date:2/11/2016)... 2016  Galmed Pharmaceuticals Ltd. (Nasdaq: GLMD ) ... development of a once-daily, oral therapy for the treatment ... Officer, Dr. Maya Halpern , has notified the Company ... Officer and from its Board of Directors effective as ... age. Allen Baharaff . Mr. Baharaff continued, ...
Breaking Medicine Technology:
Cached News: