HOME >> MEDICINE >> NEWS
JCI table of contents -- May 17, 2007

EDITOR'S PICK

Role of TRPM8 in the development of prostate cancer

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific marker and therapeutic target in prostate cancer. However, the regulation of and changes in TRPM8 during prostate cancer progression have remained unclear.

In normal prostate epithelium, cells coexist in many stages of development/differentiation progressing from stem cells to mature luminal cells. Disrupted or dysregulated differentiation and proliferation are major causes of cancer. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Natalia Prevarskaya from Universit des Sciences et Technologies de Lille, France, show that only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells possessed higher PM-TRPM8 levels than normal cells. However, endoplasmic reticulum TRPM8 (ER-TRPM8) retained its function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor.

TITLE: Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

AUTHOR CONTACT:

Natalia Prevarskaya

Universit des Sciences et Technologies d
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-May-2007


Page: 1 2 3 4 5 6 7

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents: May 10, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents May

(Date:4/1/2015)... Nike Golf Camps has expanded with the ... Florida. These programs are specifically designed for the competitive ... golf-intensive environment and to learn about the college recruiting ... coaching legend, Rick LaRose, spends significant time evaluating each ... it pertains to the recruiting and college search process, ...
(Date:4/1/2015)... Poisonous plants (poison ivy, oak and ... recent years, increasing significantly in number and rash-causing potency. ... to poison plants (according to the American Academy of ... summer adventures in nature, they should be aware that ... greater than ever. This year, Ivarest adds a new ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 Due ... started to hire more caregivers, staffing personnel, and ... and care managers within the Greater Los Angeles ... training institution, 1Heart Caregiver University has firmed up ... its mission to provide quality in-home care through ...
(Date:3/31/2015)... 01, 2015 Every day a new ... American diet) contains things banned in other countries, and ... every year. AlignLife Chiropractic & Natural Health Centers believe ... their communities they can reduce the future development of ... each AlignLife clinic offers workshops at no charge in ...
(Date:3/31/2015)... March 31, 2015 As the demand ... is pledging to have a mobile-friendly website online sometime ... part of Chunk Fitness’ continued commitment to bring the ... user base. All of the same great fitness information ... will be substantially easier to read while browsing on ...
Breaking Medicine News(10 mins):Health News:US Sports Camps and Nike Golf Camps to Host Golf Development Camps in Arizona and Florida 2Health News:US Sports Camps and Nike Golf Camps to Host Golf Development Camps in Arizona and Florida 3Health News:New Ivarest Poison Ivy Itch Spray Provides All-Day Comfort 2Health News:1Heart Ends 1st Quarter of the Year With 1Heart Caregiver University Training of New Staff and Commits To Provide More Jobs For Year 2015 2Health News:1Heart Ends 1st Quarter of the Year With 1Heart Caregiver University Training of New Staff and Commits To Provide More Jobs For Year 2015 3
(Date:3/31/2015)... Medela has announced the addition of ... Motion™-Endure personal pumps to its Negative Pressure Wound ... new devices, along with the Invia ® ... innovative, high-quality NPWT solutions, designed to provide safe ... "We are happy to be able to ...
(Date:3/31/2015)... 2015   Halyard Health (NYSE: HYH ... awarded a new purchasing agreement with HealthTrust ... 1, 2015, Halyard,s standard and ASTM-rated face masks ... be available to HealthTrust members made up of 1,350 ... centers, physician practices and alternate care facilities. ...
(Date:3/31/2015)... VANCOUVER, British Columbia , March 31, 2015 ... IMLFF), a clinical stage biopharmaceutical company that specializes ... announced the appointment of Paul C. Anderson ... Anderson is a pharma industry veteran who brings ... Dr. Anderson is a synthetic organic ...
Breaking Medicine Technology:Medela Launches Product Line to Support Individualized Care For Negative Pressure Wound Therapy Patients 2Halyard Health Signs First GPO Contracts As Independent Company 2Halyard Health Signs First GPO Contracts As Independent Company 3InMed Pharmaceuticals Strengthens Scientific Advisory Board 2InMed Pharmaceuticals Strengthens Scientific Advisory Board 3InMed Pharmaceuticals Strengthens Scientific Advisory Board 4
Cached News: