HOME >> MEDICINE >> NEWS
JCI table of contents -- May 17, 2007

EDITOR'S PICK

Role of TRPM8 in the development of prostate cancer

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific marker and therapeutic target in prostate cancer. However, the regulation of and changes in TRPM8 during prostate cancer progression have remained unclear.

In normal prostate epithelium, cells coexist in many stages of development/differentiation progressing from stem cells to mature luminal cells. Disrupted or dysregulated differentiation and proliferation are major causes of cancer. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Natalia Prevarskaya from Universit des Sciences et Technologies de Lille, France, show that only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells possessed higher PM-TRPM8 levels than normal cells. However, endoplasmic reticulum TRPM8 (ER-TRPM8) retained its function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor.

TITLE: Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

AUTHOR CONTACT:

Natalia Prevarskaya

Universit des Sciences et Technologies d
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-May-2007


Page: 1 2 3 4 5 6 7

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents: May 10, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents May

(Date:5/26/2015)... Viejo, CA (PRWEB) May 26, 2015 ... styles for Final Cut Pro X . ... suspenseful to simple and elegantly styled text. , ... in seconds. , ProTrailer Network can easily complement any ... style desired and within seconds can make professional looking ...
(Date:5/26/2015)... PA (PRWEB) May 26, 2015 ... XML Editor with the Vasont® CCMS to make ... Vasont Systems, a top component content management system ... Integrator (VUI) extension supports oXygen XML Editor Version ... The Vasont Universal Integrator extension merges key editorial ...
(Date:5/26/2015)... Many sexy cocktail dresses inspired ... dress collections recently. Now, TheCelebrityDresses.com is offering great ... to 70% off. The company aims to help ... hundreds of dollars on valuable, trendy formal outfits. ... carpet fashion special occasion dresses. Their dresses are ...
(Date:5/26/2015)... May 26, 2015 Pacifica ... during the Memorial Day weekend, celebrating the outstanding ... on Pacifica’s picturesque Ladera Lane campus, located in ... and alumni traveled to Santa Barbara from all ... , The 2015 commencement ceremonies featured ...
(Date:5/26/2015)... The professionals from Marietta Vet Clinic ... helping local rescue pets with a parking lot cookout ... Kimmerling DDS, Suzanna Aguilera DMD and Garrick McGrath DMD ... 100% of proceeds from the extravaganza. , Tents, grills ... to help save unwanted, local animals. Doctors and ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release ProTrailer Network for Final Cut Pro X 2Health News:Vasont Systems Certifies the Integration between the Vasont® Component Content Management System and oXygen® XML Editor 17.0 2Health News:Cocktail Dresses Inspired by Celebrities on Sale at TheCelebrityDresses.com 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 3Health News:"Rescue Animal Cookout" Announced at Verde Pointe Professional Park on June 25, 2015 2
(Date:5/26/2015)... 2015  SI-BONE, Inc., a medical device company that ... minimally invasive surgical (MIS) device indicated for fusion for ... that Laura Francis has joined the company ... the executive management team bringing a wealth of experience ... positions.  Prior to joining SI-BONE, Ms. ...
(Date:5/26/2015)... , May 26, 2015 Connected ... for diverse devices and workflows, aiding diagnosis, monitoring ... an infrastructure to be efficient, stakeholders must first ... place. Logo - http://photos.prnewswire.com/prnh/20150526/218313LOGO ... Sullivan, Healthcare and Medical Device Connectivity and Interoperability, ...
(Date:5/25/2015)... SHENZHEN, China, May 26, 2015  China Nepstar Chain ... a leading retail drugstore chain in China based on ... unaudited financial results for the first quarter ended March 31, ... sales increased by 13.6% compared to the first quarter ... RMB759.1 million (US$122.5 million) compared to RMB678.3 million in the ...
Breaking Medicine Technology:SI-BONE, Inc. Appoints Laura Francis Chief Financial Officer and Closes Additional Round of Growth Capital 2SI-BONE, Inc. Appoints Laura Francis Chief Financial Officer and Closes Additional Round of Growth Capital 3SI-BONE, Inc. Appoints Laura Francis Chief Financial Officer and Closes Additional Round of Growth Capital 4Interoperability among Connected Medical Devices Can Potentially Transform Healthcare 2Interoperability among Connected Medical Devices Can Potentially Transform Healthcare 3China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports First Quarter 2015 Financial Results 11
Cached News: