HOME >> MEDICINE >> NEWS
JCI table of contents, June 8, 2006

EDITOR'S PICK

HtrA1 protein contributes to the development of resistance to chemotherapy in ovarian and gastric cancers

While many cancer patients initially have a favorable response to chemotherapy for the treatment of solid tumors, resistance to treatment often develops. Resistance can be caused by many factors, including metabolism of the drug, a decrease in drug accumulation in tumor cells, altered expression of molecules involved in cell death, or further DNA mutation or modification that makes the drug ineffective. In a study appearing online on June 8 in advance of print publication in the July issue of the Journal of Clinical Investigation, Viji Shridhar and colleagues from the Mayo Clinic College of Medicine show that 2 antitumor agents, cisplatin and paclitaxel, increase the expression of the protein HtrA1 in ovarian carcinoma cells, which induces cell death. Conversely, reduced HtrA1 expression reduced the effectiveness of cisplatin and paclitaxel.

The authors went on to test whether the level of HtrA1 expression could predict the response to chemotherapy of patients with ovarian or gastric cancer receiving cisplatin-based chemotherapy. The authors found that patients with ovarian or gastric tumors expressing higher levels of HtrA1 showed a better response to chemotherapy compared to those with lower levels of HtrA1 expression. The study reveals a novel pathway by which HtrA1 mediates the ability of chemotherapeutic agents to kill cancer cells, and suggests that loss of HtrA1 in ovarian and gastric cancer may contribute to the development of resistance to chemotherapy.

TITLE: Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

AUTHOR CONTACT:
Elizabeth Zimmermann
Communications, Mayo Clinic Cancer Center, Rochester, Minnesota, USA.
Phone: (507) 284-5005; E-mail: newsbureau@mayo.edu.

View the PDF of this article at:

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
8-Jun-2006


Page: 1 2 3 4 5

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. JCI table of contents: May 1, 2007
10. Americans still not eating enough fruits and vegetables, according to 2 recent studies
11. Slow-release morphine reduces level of intractable cough

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2020)... (PRWEB) , ... February 13, 2020 , ... ... seven locations in Northern Virginia: Arlington, Dulles-Aldie, Fair Oaks, Fairfax, Fredericksburg, Leesburg, and ... that eight D.C.- and Virginia-based fertility specialists have been named as Top Docs ...
(Date:2/11/2020)... ... February 11, 2020 , ... Soterius, Inc., a ... its move to a new, significantly larger business premises in Lawrenceville, NJ. The ... in the development of digital technology platforms. , “As our customer base and ...
(Date:2/10/2020)... ... February 10, 2020 , ... A January 26 article ... in certain situations. The answer is that – not unlike the skin’s response to ... and sensitivity serve as an alert to potential damage being done and warn the ...
(Date:2/10/2020)... ... 10, 2020 , ... Terry Savage , a Westat ... of the Society for Health Communication for 2020. Ms. Savage leads ... research-driven Federal social marketing campaigns and health education programs that increase knowledge, inform ...
(Date:2/10/2020)... ... February 10, 2020 , ... Rimidi , a cloud-based ... announced its founder and chief health innovator, Lucienne Ide , MD, PhD, ... . Established in 2016, the award recognizes influential women who harness the power ...
Breaking Medicine News(10 mins):
(Date:2/11/2020)... , ... February 11, 2020 , ... ... Vitamin D powdered calcium supplement, proudly announce the addition of five new products ... a healthy body. , Like FitFormula's Classic Unflavored Calcium + Vitamin D, their ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... ... CA, is now offering EMSculpt treatments to patients. , EMSculpt is an ... approved to treat the abdomen, buttocks, thighs, calves, biceps, and triceps. The EMSculpt ...
(Date:2/10/2020)... Ky. (PRWEB) , ... February 10, 2020 , ... ... partnership with Healthstat , a leading provider of onsite health clinics. Focused ... SaaS-based population health management software, Healthward ® at its onsite employee health ...
Breaking Medicine Technology:
Cached News: