rt that human heat shock protein 60 (HSP6) stimulates human Tregs. They show that administration of HSP60, or a peptide thereof, to cultures of human T cells significantly enhanced the ability of relatively low concentrations of Tregs to downregulate the activity of other T cells. They found that this involves signaling via Toll-like receptor 2 (TLR2). The results of this study provide important new insights into Treg signaling and how Tregs affect the immune function of regulated T cells. Clinically, the upregulation of Treg function has important implications for the control of autoimmune diseases and other inflammatory diseases such as lupus and rheumatoid arthritis.

TITLE: Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling

AUTHOR CONTACT:
Irun R. Cohen
Weizmann Institute of Science, Rehovot, Israel.
Phone and Fax: 972-8-934-2911; E-mail: irun.cohen@weizmann.ac.il.

View the PDF of this article at: https://www.the-jci.org/article.php?id=28423

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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
8-Jun-2006

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