HOME >> MEDICINE >> NEWS
JCI table of contents: January 19, 2006

DF of this article at: https://www.the-jci.org/article.php?id=24742

OPHTHALMOLOGY
Making new blood vessels: keeping the lines of sight open

The creation of new blood vessels, known as angiogenesis, is a process used to supply oxygen and nutrients at sites of tissue injury. Angiogenesis is known to be stimulated during hypoxia (low oxygen conditions, when new vessels are needed). However, the mechanisms by which hypoxia leads to new vessel formation is poorly understood. In the mouse retina specialized cells called astrocytes regulate angiogenesis by producing a structural support protein known as fibronectin during hypoxia, but until now it was unclear what triggered this pro-angiogenic event. In a new study appearing online on January 19 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, Akiyoshi Uemura and colleagues from the RIKEN Center for Developmental Biology in Japan show that a nuclear protein called Tlx in pro-angiogenic astrocytes is regulated by oxygen levels. Mice that were genetically engineered so that they would not express Tlx (known as "Tlx knockout" mice) show a complete absence of retinal blood vessels even though other pro-angiogenic markers are expressed. To determine whether the astrocytes were altered, the authors analyzed fibronectin levels in normal and Tlx knockout mouse retinas. The Tlx knockout astrocytes did not form fibronectin matrices, thus explaining the failure of these mice to undergo retinal angiogenesis. The authors also discovered that Tlx is induced by low oxygen levels and that Tlx gene levels are downregulated during hyperoxia (too much oxygen), revealing that Tlx is an oxygen-sensing switch in retinal astrocytes. Together these studies demonstrate that oxygen-sensing Tlx plays an indispensable role in the development of healthy vascularized retinas via the regulation of formation
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Jan-2006


Page: 1 2 3 4 5 6

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. JCI table of contents: May 1, 2007
10. Americans still not eating enough fruits and vegetables, according to 2 recent studies
11. Slow-release morphine reduces level of intractable cough

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents January

(Date:5/22/2015)... 2015 Bryce Henson, local fitness icon ... Boot Camp, recently accepted his program’s 100th client. Henson ... launch of his location evidences the powerful impact his ... Fit Body Boot Camp is the nation’s most popular ... hundreds of locations across North America, Europe and Australia. ...
(Date:5/22/2015)... Yisrayl Hawkins, Pastor and Overseer at The House of ... on religious leaders to make changes in order to achieve ... blog, discusses the history of war, how it started, why ... says mankind was created to lead peaceful, joyful lives, very ... , “Yahweh created mankind, according to His Plan, which is ...
(Date:5/22/2015)... India Network Foundation sponsors various community events in ... India Network Visitor Health insurance is one of ... hundreds and thousands of families every year. India ... famous playback singer from Mumbai, Smt. Anuradha Paudwal to ... Florida activities. , Anuradha Paudwal is a ...
(Date:5/21/2015)... WellCare Health Plans, Inc. (NYSE: WCG) announced today that its ... Kids Corporation (FHKC) to continue to provide managed care services ... Florida Healthy Kids (FHK) program. Pending execution, the two-year contract ... for two additional years at FHKC’s discretion. , Staywell will ... who live in Regions 1, 2, 3, 4, 5, 8, ...
(Date:5/21/2015)... Ticket Down is a reliable source for authentic ... Guatemala on Friday, July 3rd at LP Field in Nashville, ... fan of international soccer. The number of chances to watch some ... is growing at a large clip. Over the past several years, ... USA to play in front of the American people. The match ...
Breaking Medicine News(10 mins):Health News:Healthy Living Brought to Anaheim— New Fitness Boot Camp Acquires 100 Clients 2Health News:Yisrayl Hawkins Calls on All Religions to Wake Up and Make Drastic Changes to End Suffering in New Letter 2Health News:India Network Visitor Health Insurance Announces Corporate Sponsorship of Anuradha Paudwal Musical in Orlando to Help Fundraise for Hindu Society of Central Florida. 2Health News:WellCare Selected to Continue Participating in the Florida Healthy Kids Program, Will Serve Nine Florida Regions Under the New Contract 2Health News:USA vs. Guatemala Tickets: Ticket Down Slashes United States Men's Soccer Team (USMNT) vs. Guatemala Tickets at LP Field in Nashville on 7/3/15 2
(Date:5/21/2015)...  Abaxis, Inc. (NasdaqGS: ABAX ), a medical ... that Ross Taylor , vice president of business ... chief financial officer effective August 1, 2015, will present ... Wednesday, May 27, 2015 at 10:20 a.m. ET. The ... New York City . ...
(Date:5/21/2015)... , May 21, 2015 Delcath Systems, ... cholangiocarcinoma (ICC) study cohort of its expanded Global Phase ... the treatment of  patients with unresectable hepatocellular carcinoma (primary ... The ICC study will be conducted at the same ... the Company,s Phase 2 HCC trial, and ICC enrollment ...
(Date:5/21/2015)... , May 21, 2015 Frost ... while two-thirds of laboratories use commercial software or ... one-third represents uncaptured market share for suppliers. With ... developing custom systems in-house, it is clear that ... This indicates that suppliers have a chance to ...
Breaking Medicine Technology:ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 2ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 3ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 4Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 2Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 3Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 4
Cached News: