HOME >> MEDICINE >> NEWS
JCI table of contents: January 19, 2006

of the fibronectin scaffold by pro-angiogenic astrocytes.

TITLE: Tlx acts as a pro-angiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes

AUTHOR CONTACT:
Akiyoshi Uemura
RIKEN Center for Developmental Biology, Kobe, Japan
Phone: 81-78-306-1924; Fax: 81-78-306-1895; E-mail: auemura@cdb.riken.jp

View the PDF of this article at: https://www.the-jci.org/article.php?id=25964

IMMUNOLOGY
TLR2 both triggers and tames the immune response

It is an established premise that invading pathogens release antigens that bind to Toll-like receptors (TLR ligands) on the surface of various cells of the immune system. This event stimulates specialized immune cells to release secreted proteins that activate other immune cells, such as T cells, to join the fight to destroy invading bacteria or fungi. The proliferation and activity of T cells is carefully controlled by a subset of cells known as regulatory T cells (Tregs). Treg depletion may allow an overzealous immune response to turn against the body's own tissues, resulting in autoimmune disorders such as arthritis and diabetes, while overactive Tregs can hinder the immune response against a foreign pathogen. In a study in mice appearing online on January 19 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, Gosse Adema and colleagues at the Radboud University Nijmegen Medical Centre in The Netherlands, reveal that the type 2 TLR (TLR2) lies at the center of how Tregs know when to suppress and when not to suppress the immune response. The authors show that during infection of mice with the fungus Candida albicans, TLR2 ligands bind directly to TLR2 on Tregs and promote Treg proliferation. Interestingly, this binding also temporarily inhibits the suppressive activ
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Jan-2006


Page: 1 2 3 4 5 6

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. JCI table of contents: May 1, 2007
10. Americans still not eating enough fruits and vegetables, according to 2 recent studies
11. Slow-release morphine reduces level of intractable cough

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology:
Cached News: