HOME >> MEDICINE >> NEWS
JCI table of contents: May 1, 2007

EDITOR'S PICK

OCT1 required for therapeutic effects of diabetes drug Metformin

The drug metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes and results in an array of therapeutic benefits. Although it has been used for over 30 years, only recently have studies begun to reveal the molecular events responsible for its therapeutic effects. Notably, these studies have shown that metformin acts by phosphorylating the enzyme AMPK, the cellular "energy-sensor", leading to a variety of cellular responses important in diabetic therapy.

A set of mouse and human studies led by Kathleen Giacomini from the University of California, San Francisco and reported in the May 1st issue of the Journal of Clinical Investigation, show that mice lacking organic cation transporter 1 (OCT1) have reduced effects of metformin on AMPK phosphorylation and a decreased ability to control glucose levels. The authors also identified seven mutations in OCT1 in humans that reduce metformin uptake. These studies indicate that OCT1 is important in mediating the therapeutic effects of metformin and that genetic variation in OCT1 in diabetics may contribute to the varied patient responses to this drug.

In an accompanying commentary, Marc Reitman and Eric Schadt from Merck and Rosetta Inpharmatics, respectively, discuss how the identification of individuals that possess specific mutations in certain genes, which are known to affect the action of a particular drug, may eventually help clinicians devise personalized treatment regimes that ensure administration of the right drug for the right person at the right time. They conclude that "tailoring therapeutic choices to the individual should allow lower and better-tolerated doses of drugs that are simultaneously safer and more efficacious. One could eliminate trial-and-error periods of switching among the nine classes of diabetes drugs."

TITLE: Effect of genetic
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
1-May-2007


Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... ... CentrAlert, Inc. today announced the launch of their free ... NOW!, which is available for Apple and Android , seeks to ... application. , “When COVID-19 first hit, there was so much that we didn’t know,” ...
(Date:8/5/2020)... ... August 04, 2020 , ... MemoryCare.com , ... announced the Best Memory Care Facilities in Austin, Texas. The guide identifies 14 ... , According to the Alzheimer’s Association , 5.6 million people aged ...
(Date:8/3/2020)... Ariz. (PRWEB) , ... August 03, 2020 , ... ... announced today the launch of its newest product, CoverageCoach. The site provides a ... compare, and purchase insurance products. The company sees CoverageCoach as an important expansion ...
(Date:7/31/2020)... , ... July 31, 2020 , ... ... Meridian Clinical Research’s internal medicine site in Savannah, GA. Visitors included ... OWS. , In May, the federal government announced the OWS program to accelerate ...
(Date:7/31/2020)... ... July 31, 2020 , ... ... Anderson issued the following statement today regarding the nation’s ongoing preparations for the ... and the nation with an efficient, effective and essential component of vaccine deployment. ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... ... Fifty six percent of older adults think we need to invest more ... like COVID-19, according to a new survey by The Senior Citizens League (TSCL). ... this year,” says Mary Johnson, a Medicare, and Social Security policy analyst for The ...
(Date:8/3/2020)... ATLANTA (PRWEB) , ... August 03, 2020 , ... ... Business Continuity Emergency Operations Planning services for small business owners. ... be unable to manage or communicate with their teams for 30-90 days as ...
(Date:7/31/2020)... Texas (PRWEB) , ... July 31, 2020 , ... As ... Studios has been providing residents of Missouri City, TX, with a wide range ... 6, Suite 300, is a state-of-the-art dental facility that is not far from the ...
Breaking Medicine Technology:
Cached News: