HOME >> MEDICINE >> NEWS
JCI table of contents: May 10, 2007

vard Medical School, Boston, Massachusetts, USA.
Phone : (617) 278-6617; Fax : (617) 278-3368; E-mail : bergmeier@cbrinstitute.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=30575


CARDIOLOGY

Protecting the heart against mechanical stress

Enlargement or overgrowth of heart cells known as cardiomyocytes cardiac hypertrophy is a common event in many heart diseases, and occurs in an effort to restore stresses on the heart wall to normal levels. A protein called ST2 that is produced by cardiomyocytes is a potentially useful biomarker in heart diseases, however its role in heart disease has been unclear. In a study appearing online on May 10 in advance of publication in the June print issue of the Journal of Clinical Investigation, Richard Lee and colleagues from Harvard Medical School show that ST2 and its recently identified ligand IL-33 work together to protect the heart in times of cardiac stress.

The authors showed that deletion of ST2 in mice increased cardiac hypertrophy as well as the thickening and scarring of heart tissue, and decreased survival of these animals in response to cardiac stress. Administration of IL-33, which is made by cells called fibrbroblasts, improved pathological changes and survival in response to cardiac stress in mice with intact ST2, but not in ST2-/- mice. The study suggests that IL-33/ST2 signaling is a crucial mechanism for protecting the heart and shows that cardiomyocytes and cardiac fibroblasts signal to each other in times of cardiac stress.

TITLE: IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

AUTHOR CONTACT:
Richard Lee
Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone : (617) 768-8272; Fax: (61
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
10-May-2007


Page: 1 2 3 4 5

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... ... STAT courier is pleased to announce that due to customer demand, as well ... presence in Dallas. One of the most exciting parts for STAT is that the ... and Forth Worth market. STAT takes pride in treating their employees with integrity and ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital health ... led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) and ... to serve more consumers who are managing chronic conditions or simply want ...
(Date:12/8/2016)... Goodyear, AZ (PRWEB) , ... December 08, 2016 ... ... planning firm with offices that serve communities in and around the greater Phoenix ... to the Homeless Youth Connection. , The mission of the Homeless Youth Connection ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a Wichita-based ... and around central Kansas, is joining the Youth Horizons organization for a charity ... Headquartered in Wichita, Youth Horizons works to empower area children from unstable, troubled, ...
(Date:12/7/2016)... ... 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare lighting for ... is a multi-function, sealed, LED luminaire that meets the needs of everyone in the ... needed. , A 2’ x 4’ model features four modes: reading, ambient, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016  Boehringer Ingelheim announced today that ... Index (CEI). This is the ninth time that the ... as a Best Place to Work for LGBT Equality. ... is a national benchmarking report on corporate policies and ... and transgender (LGBT) employees. "We are ...
(Date:12/8/2016)... 8, 2016 According to a new market research ... Fetal), Therapeutic (Pain, Insulin)), End Use (Sports, Fitness, RPM), Type (Smart watch, ... the global market, in terms of value, is projected to reach 12.14 ... of 18.0% during the forecast period. Continue ... ...
(Date:12/8/2016)... 2016 Augmedix, the nation,s leading smartglass-based ... closed a $23 million strategic round of funding ... company seeks to rehumanize the physician patient relationship ... EHR documentation. The Augmedix core offering is a ... from 3 hours of mandated charting and documentation ...
Breaking Medicine Technology:
Cached News: