HOME >> MEDICINE >> NEWS
JCI table of contents: May 10, 2007

vard Medical School, Boston, Massachusetts, USA.
Phone : (617) 278-6617; Fax : (617) 278-3368; E-mail : bergmeier@cbrinstitute.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=30575


CARDIOLOGY

Protecting the heart against mechanical stress

Enlargement or overgrowth of heart cells known as cardiomyocytes cardiac hypertrophy is a common event in many heart diseases, and occurs in an effort to restore stresses on the heart wall to normal levels. A protein called ST2 that is produced by cardiomyocytes is a potentially useful biomarker in heart diseases, however its role in heart disease has been unclear. In a study appearing online on May 10 in advance of publication in the June print issue of the Journal of Clinical Investigation, Richard Lee and colleagues from Harvard Medical School show that ST2 and its recently identified ligand IL-33 work together to protect the heart in times of cardiac stress.

The authors showed that deletion of ST2 in mice increased cardiac hypertrophy as well as the thickening and scarring of heart tissue, and decreased survival of these animals in response to cardiac stress. Administration of IL-33, which is made by cells called fibrbroblasts, improved pathological changes and survival in response to cardiac stress in mice with intact ST2, but not in ST2-/- mice. The study suggests that IL-33/ST2 signaling is a crucial mechanism for protecting the heart and shows that cardiomyocytes and cardiac fibroblasts signal to each other in times of cardiac stress.

TITLE: IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

AUTHOR CONTACT:
Richard Lee
Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone : (617) 768-8272; Fax: (61
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
10-May-2007


Page: 1 2 3 4 5

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents May

(Date:3/31/2015)... (PRWEB) March 31, 2015 As the ... Fitness is pledging to have a mobile-friendly website online ... is part of Chunk Fitness’ continued commitment to bring ... growing user base. All of the same great fitness ... it will be substantially easier to read while browsing ...
(Date:3/31/2015)... CA (PRWEB) March 31, 2015 Cosmetic ... on the Internet, is proudly enduring adding news to ... doctors and the consumers of plastic surgery and cosmetic ... more user-friendly pages and interconnected sections, the Cosmetic Town ... newest addition to the Cosmetic Town site navigation, News ...
(Date:3/31/2015)... 31, 2015 In conjunction with ... April 1-7, the Mesothelioma Applied Research Foundation (Meso ... program, to complement its existing work in mesothelioma ... part of the Meso Foundation’s mission, we want ... diseases related to asbestos, including mesothelioma,” said the ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 In ... (ADS) is offering advice for buying from a ... Dealers Association (NMEDA) is a nonprofit organization that ... in the manufacturing and installation of mobility equipment. ... in the industry that consistently adhere to the ...
(Date:3/31/2015)... March 31, 2015 Calling all runners, walkers ... and other tick-borne diseases! The first annual “Lyme Walk & ... Park in Stamford, CT. The event, hosted by Lyme ... will raise funds to support research and education about Lyme ... to all ages and abilities, will feature 5K and 10K ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town is Now Transforming so Consumer can Better Navigate 2Health News:Mesothelioma Research Organization Announces New Prevention Program 2Health News:Mesothelioma Research Organization Announces New Prevention Program 3Health News:Advanced Driving Systems Celebrates National Disability Month 2Health News:Lyme Research Alliance & Tick-Borne Disease Alliance to Kick-Off 1st “Lyme Walk & Run” Event, April 26 2
(Date:3/31/2015)...  Dr. Renu Razdan of leading Indian CRO ... Congress in April to discuss the latest, progressive announcement regarding ... drugs below: India,s Drugs ... Health that if a new drug is approved and marketed ... India with waiver of clinical trial ...
(Date:3/31/2015)... ALPHARETTA, Ga. , March 31, 2015   ... Health Care, today announced it was awarded a new ... line of face masks. Effective March 1, 2015, Halyard,s ... masks with SO SOFT* lining, will be available to ... as well as 15,000 ambulatory surgery centers, physician practices ...
(Date:3/31/2015)... NEW YORK , March 31, 2015 ... ) announced today that it intends to expand its ... fully human monoclonal antibody targeting eotaxin-1. Bullous Pemphigoid is ... approximately 60,000 patients in the US and ... expects to start enrolling patients in a Phase II ...
Breaking Medicine Technology:Max Neeman to Discuss India's Orphan Drug Regulations at WOD 2015 2Halyard Health Signs First GPO Contracts As Independent Company 2Halyard Health Signs First GPO Contracts As Independent Company 3Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 2Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 3Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 4
Cached News: