JCI table of contents: May 10, 2007

vard Medical School, Boston, Massachusetts, USA.
Phone : (617) 278-6617; Fax : (617) 278-3368; E-mail : bergmeier@cbrinstitute.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=30575


Protecting the heart against mechanical stress

Enlargement or overgrowth of heart cells known as cardiomyocytes cardiac hypertrophy is a common event in many heart diseases, and occurs in an effort to restore stresses on the heart wall to normal levels. A protein called ST2 that is produced by cardiomyocytes is a potentially useful biomarker in heart diseases, however its role in heart disease has been unclear. In a study appearing online on May 10 in advance of publication in the June print issue of the Journal of Clinical Investigation, Richard Lee and colleagues from Harvard Medical School show that ST2 and its recently identified ligand IL-33 work together to protect the heart in times of cardiac stress.

The authors showed that deletion of ST2 in mice increased cardiac hypertrophy as well as the thickening and scarring of heart tissue, and decreased survival of these animals in response to cardiac stress. Administration of IL-33, which is made by cells called fibrbroblasts, improved pathological changes and survival in response to cardiac stress in mice with intact ST2, but not in ST2-/- mice. The study suggests that IL-33/ST2 signaling is a crucial mechanism for protecting the heart and shows that cardiomyocytes and cardiac fibroblasts signal to each other in times of cardiac stress.

TITLE: IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

Richard Lee
Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone : (617) 768-8272; Fax: (61

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:

(Date:11/24/2015)... ... , ... With Thanksgiving right around the corner, holiday travel season is about ... family and vehicle. , According to the National Highway Traffic Safety Administration, 301 people ... the following safety tips from the NHTSA: , ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... Cleveland University-Kansas City (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester student ... President Carl S. Cleveland III on October 16. , “Katie is very excited ...
(Date:11/24/2015)... ... November 24, 2015 , ... Bibliomotion is thrilled to ... Me about Reinvention and Diversity by Nancy M. Schlichting, Chief Executive Officer ... failing to adequately address the needs of patients and their families, shaped my desire ...
(Date:11/24/2015)... ... 2015 , ... All her life, Don Peck’s mother wondered if she was a descendant of ... been. After a 25-year search for information, Don and his aunt discovered that she ... name. Turns out, it was Don’s father who was descended from not one, but ...
(Date:11/24/2015)... ... 24, 2015 , ... GBCHealth and Global Health Council announced ... to the world’s best corporate-supported global health programs. The awards were presented ... held in Washington D.C and attended by over 150 representatives from the international ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... and BERN, Switzerland , November ... ARTORG Center for Biomedical Engineering Research of the University ... Division of Endocrinology, Diabetes and Clinical Nutrition of the ... start of an exclusive collaboration to develop a novel ... for the personalised delivery of insulin for diabetic patients ...
(Date:11/24/2015)... , November 24, 2015 st  Scientific ... North America (RSNA) taking place in Chicago ... Booth 1122, Hall A. --> st  Scientific Assembly and ... (RSNA) taking place in Chicago ... Hall A. --> Molecular Dynamics will present its revolutionary ...
(Date:11/24/2015)... The uptake of recently approved and pipeline premium products for Type 1 ... 2021, says GBI Research . --> ... Diabetes Mellitus (T1DM), will be a key driver of market growth to ... The uptake of recently approved and pipeline premium products for Type ... to 2021, says GBI Research . ...
Breaking Medicine Technology:
Cached News: