HOME >> MEDICINE >> NEWS
JCI table of contents: May 10, 2007

vard Medical School, Boston, Massachusetts, USA.
Phone : (617) 278-6617; Fax : (617) 278-3368; E-mail : bergmeier@cbrinstitute.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=30575


CARDIOLOGY

Protecting the heart against mechanical stress

Enlargement or overgrowth of heart cells known as cardiomyocytes cardiac hypertrophy is a common event in many heart diseases, and occurs in an effort to restore stresses on the heart wall to normal levels. A protein called ST2 that is produced by cardiomyocytes is a potentially useful biomarker in heart diseases, however its role in heart disease has been unclear. In a study appearing online on May 10 in advance of publication in the June print issue of the Journal of Clinical Investigation, Richard Lee and colleagues from Harvard Medical School show that ST2 and its recently identified ligand IL-33 work together to protect the heart in times of cardiac stress.

The authors showed that deletion of ST2 in mice increased cardiac hypertrophy as well as the thickening and scarring of heart tissue, and decreased survival of these animals in response to cardiac stress. Administration of IL-33, which is made by cells called fibrbroblasts, improved pathological changes and survival in response to cardiac stress in mice with intact ST2, but not in ST2-/- mice. The study suggests that IL-33/ST2 signaling is a crucial mechanism for protecting the heart and shows that cardiomyocytes and cardiac fibroblasts signal to each other in times of cardiac stress.

TITLE: IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

AUTHOR CONTACT:
Richard Lee
Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone : (617) 768-8272; Fax: (61
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
10-May-2007


Page: 1 2 3 4 5

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. New treatments needed for irritable bowel syndrome
8. JCI table of contents: May 1, 2007
9. Americans still not eating enough fruits and vegetables, according to 2 recent studies
10. Slow-release morphine reduces level of intractable cough
11. Less television and more gathering around the dinner table prevents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology:
Cached News: