HOME >> MEDICINE >> NEWS
JCI table of contents: May 4, 2006

AUTHOR CONTACT:
Paul J. Bryce
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Phone: (312) 503-0077; Fax: (312) 503-0078; E-mail: p-bryce@northwestern.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=26150

BONE BIOLOGY

Peptide inhibitor may prevent bone loss in osteoporosis

Two molecules known as RANK and TNFR promote the differentiation of osteoclasts cells that are responsible for the breakdown of bone. This process occurs in healthy individuals as part of the constant renewal of the bone that makes up our skeleton, and it occurs at an increased rate in individuals with diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease. A site on TNFR that is critical for the binding of activating molecules is also conserved, in part, on RANK. In a study appearing online on May 4 in advance of print publication in the June issue of the Journal of Clinical Investigation, Roland Baron and colleagues from Yale University School of Medicine show that mimicking a critical loop of TNFR and RANK with a small cyclic peptide allows the inhibition of RANK ligandinduced bone breakdown and resorption in mouse models of osteoporosis. The authors used molecular modeling to demonstrate the exact region where the peptide binds and interferes with RANK signaling. These findings pave the way for the development of new strategies for designing peptide as well as nonpeptide inhibitors of RANK ligandinduced osteoclast-mediated bone loss, which is a key pathway in the mechanisms at work in many bone and joint diseases.

TITLE: A TNF receptor loop peptide mimic blocks RANK ligandinduced signaling, bone resorption, and bone loss

AUTHOR CONTACT:
Roland Baron
Yale University School of Medicine, New Haven, Connecticut, USA.
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
4-May-2006


Page: 1 2 3 4

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. JCI table of contents: May 1, 2007
10. Americans still not eating enough fruits and vegetables, according to 2 recent studies
11. Slow-release morphine reduces level of intractable cough

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... 2017 , ... An in-depth computational analysis of genetic variants implicated in both ... genes that may explain why susceptibility to one of the disorders could place individuals ... today in the journal npj Schizophrenia. , “There is a wealth of genomic ...
(Date:2/24/2017)... Texas (PRWEB) , ... February 24, 2017 , ... ... to The Medical Center at Craig Ranch building at 8080 State Highway 121, Suite ... Medical District with easy access to Highway 121. , As the practice has grown, ...
(Date:2/24/2017)... ... , ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 ... image mannequin art competition. Selected from 15 submissions from around the nation, the top ... 31st annual iaedp Symposium, March 22 – 26 in Las Vegas. , This year, ...
(Date:2/24/2017)... ... February 24, 2017 , ... Castle ... hosted their Military Wedding Giveaway, with the winning couple announced on Feb. 14, ... services generously donated from local vendors: A Matter of Taste, Ryan Rousseau Enterprises, ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... clinician-based audience, will be participating in Rare Disease Day events, hosted by the ... addition, Rare Disease Report, a website, weekly e-newsletter and quarterly publication, will be ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Februar 2017 LG Innotek hat heute die ... Sterilisationsleistung beträgt das 1,5-fache des 45-mW-Moduls der Konkurrenz. ... zwischen 200 und 280 nm und eignet sich damit für ... ihre DNA zerstört. Das Produkt von LG Innotek erzeugt ... ...
(Date:2/23/2017)... Im Rahmen seiner Schlüsselwachstumsstrategie arbeitet die Guian ... Provinz Guizhou, 2017 mit dem Angebot von Anreize schaffenden Strategien ... einer eingebetteten Hightech-Schlüsselindustrie. Foto - http://mma.prnewswire.com/media/471342/First_CRH__CHina_Railway_High_Speed__Train_Enters_Guian.jpg ... ... ...
(Date:2/23/2017)... New York , February 23, 2017 ... implications arising from increasing caseload for varicose veins in ... across the globe are prompting the adoption of endovenous ... study on global endovenous laser therapy market, ... towards aftereffects of lifestyle choices and consequences of obesity ...
Breaking Medicine Technology:
Cached News: