JCI table of contents: May 4, 2006

Paul J. Bryce
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Phone: (312) 503-0077; Fax: (312) 503-0078; E-mail: p-bryce@northwestern.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=26150


Peptide inhibitor may prevent bone loss in osteoporosis

Two molecules known as RANK and TNFR promote the differentiation of osteoclasts cells that are responsible for the breakdown of bone. This process occurs in healthy individuals as part of the constant renewal of the bone that makes up our skeleton, and it occurs at an increased rate in individuals with diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease. A site on TNFR that is critical for the binding of activating molecules is also conserved, in part, on RANK. In a study appearing online on May 4 in advance of print publication in the June issue of the Journal of Clinical Investigation, Roland Baron and colleagues from Yale University School of Medicine show that mimicking a critical loop of TNFR and RANK with a small cyclic peptide allows the inhibition of RANK ligandinduced bone breakdown and resorption in mouse models of osteoporosis. The authors used molecular modeling to demonstrate the exact region where the peptide binds and interferes with RANK signaling. These findings pave the way for the development of new strategies for designing peptide as well as nonpeptide inhibitors of RANK ligandinduced osteoclast-mediated bone loss, which is a key pathway in the mechanisms at work in many bone and joint diseases.

TITLE: A TNF receptor loop peptide mimic blocks RANK ligandinduced signaling, bone resorption, and bone loss

Roland Baron
Yale University School of Medicine, New Haven, Connecticut, USA.

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4

Related medicine news :

1. International symposium on fruit, vegetables headed for Houston
2. Stevens Roundtable: Health, Technology & Society, July 11
3. FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
4. Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
5. Clinical review -- A psychological approach to the management of irritable bowel syndrome
6. JCI table of contents -- May 17, 2007
7. JCI table of contents: May 10, 2007
8. New treatments needed for irritable bowel syndrome
9. JCI table of contents: May 1, 2007
10. Americans still not eating enough fruits and vegetables, according to 2 recent studies
11. Slow-release morphine reduces level of intractable cough

Post Your Comments:
TAG: JCI table contents May

(Date:10/9/2015)... ... October 09, 2015 , ... "My spouse and I rely on canes to ... something," said an inventor from Buffalo, N.Y. "This is not only frustrating but it’s ... CANE REST enables a user to keep a cane upright while it’s not in ...
(Date:10/9/2015)... ... October 09, 2015 , ... Matrix IT Medical ... specifications for TRACTUS, the world’s first sterile field scanner. , The ... to the FDA’s recent Unique Device Identifier (UDI) Final Rule, which will require ...
(Date:10/9/2015)... PA (PRWEB) , ... October 09, 2015 , ... "As ... of two inventors from Philadelphia, Pa. "They have to wear large diapers or pads. ... solutions." , They developed the TROUSAFE to absorb urine leaking from the tip of ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... oldest and largest recreational dispensaries in Colorado, says the latest figures on the ... rapidly and maturing into a legitimate industry. , Last month, according to ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... staffing franchise, was recognized by Cabarrus County Active Living and Parks for its ... home care company’s dedication to consistently going above and beyond the call ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... and CINCINNATI , Oct. 9, 2015 ... two Design Thinking labs with Konica Minolta Medical Imaging ... CFI to utilize Design Thinking to help healthcare providers ... future using a visual roadmap that they can customize ... --> Primary Imaging is the initial procedure, or ...
(Date:10/9/2015)... 9, 2015 RedRick Technologies, a ... solutions and reading room design guidance, is ... Radiology realize their vision of a reading ... design guidance and radiologist reading workstations that ... George Bisset , radiologist-in-chief and ...
(Date:10/9/2015)... , October 9, 2015 ... --> The report summarizes key ... overall status of the manufacturers making ... and direction for companies and individuals ... http://www.lifescienceindustryresearch.com/global-and-chinese-cochlear-implant-industry-2015-market-research-report.html . --> ...
Breaking Medicine Technology:
Cached News: