HOME >> MEDICINE >> NEWS
Jefferson researchers discover that nanoparticle shows promise in reducing radiation side effects

-protective agent, CD60_DF1.

To test how well it worked, they turned to tiny zebrafish embryos, which are transparent for the first month of life and allow scientists to observe closely organ damage produced by cancer treatments. Zebrafish have most of their organs formed by the third day after fertilization.

They gave the embryos different doses of ionizing radiation as well as treatment by either Amifostine, which acted as a control agent, or CD60_DF1. First, they found that CD60_DF1 had almost no toxicity. Then, they saw that CD60_DF1 given before and even immediately after--up to 30 minutes--exposure to X-rays reduced organ damage by one-half to two-thirds, which was as good as the level of protection given by Amifostine.

"We also showed that the fullerene provided organ-specific protection," Dr. Dicker notes. "It protected the kidney from radiation-induced damage, for example, as well as certain parts of the nervous system."

He explains that one way that radiation frequently damages cells and tissues is by producing "reactive oxygen species"--oxygen radicals, peroxides and hydroxyls. The scientists showed that zebrafish embryos exposed to ionizing radiation had more than 50 percent reduction in the production of reactive oxygen species compared to untreated embryos.

Dr. Dicker says that the company has technology enabling certain molecules to be attached to the nanoparticles, which will allow for targeting to specific tissue and organs, further enhancing use of the nanoparticles.

Dr. Dicker and his team plan follow-up studies using mouse models that will allow them to find out whether fullerene protects the entire animal from radiation, and how it works to protect specific organs. They also are interested in exploring its ability to prevent long-term side effects of radiation, such as fibrosis.


'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
5-Apr-2006


Page: 1 2

Related medicine news :

1. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
2. Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
3. Jefferson immunology researchers show blood-brain barrier damage could affect MS severity
4. Jefferson scientists find that plavix appears to be safe during and after heart bypass
5. Treatment of in-hospital cardiac patients is focus of Jefferson University presentations
6. Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
7. Empathy skills must be given a high priority in medical education, says Jefferson author
8. Natural, soy-based substance might help fight MS, Jefferson neuroscientists find
9. Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
10. Obesity tied to higher risk of complications in spinal surgery, Jefferson neurosurgeon finds
11. Jefferson Orthopaedic surgeons leading international study of timing of spinal surgery

Post Your Comments:
(Date:2/27/2015)... FL (PRWEB) February 27, 2015 Today, February ... KAJ Brothers , along with LXR Organics ... the END IT Campaign to raise awareness and promote prevention, ... to statistics provided by the END IT Coalition, slavery is ... per year and exists in 167 countries around the world. ...
(Date:2/27/2015)... CA (PRWEB) February 27, 2015 Clinovo, ... ClinCapture, its validated Electronic Data Capture (EDC) at the ... California on March 2nd and March 3rd at Booth ... self-service platform and DIY CRF and edit-check builder allowing ... in a matter of days, without any programming experience. ...
(Date:2/27/2015)... February 27, 2015 Altec Products, Inc., ... their Sage ERP Document Management Partner of the Year. ... Sage CRM and other complimentary solutions for their customers ... side-by-side for many years to provide clients with paperless ... , “We are thrilled to recognize ADSS Global ...
(Date:2/27/2015)... GA (PRWEB) February 27, 2015 In honor of ... for Primary Care (CPC) South office, is offering tips on how ... cause of death, but that doesn't mean people have to accept ... change some risk factors — such as family history, sex or ... take. , Dr. Scott has six helpful tips to improve ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Undocumented ... are documented to use Medicaid, the federal health ... according to a new study from UC Davis ... greatest predictor of farmworker use of Medicaid, which ... regardless of documentation status, was having children. ...
Breaking Medicine News(10 mins):Health News:KAJ Brothers Join the Campaign to 'End It - Shine A Light On Slavery' 2Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2Health News:Altec Announces 2014 Sage ERP Document Management Partner of the Year Award Recipient 2Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 2Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 3
(Date:2/26/2015)... 2015 RnRMarketResearch.com adds Corneal ... report to its store. This report p provides ... The report "Corneal Ulcers - Pipeline Review, H2 ... for Corneal Ulcers. Corneal Ulcers are primarily result ... viral infections & fungal infections. The symptoms of ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015  IRIDEX Corporation (NASDAQ: ... its fourth quarter and full year 2014 financial results after ... In conjunction with the release, the Company will host a ... Eastern Time on Thursday, March 5, 2015 ... developments. Interested parties may access the live conference ...
(Date:2/26/2015)... , Feb. 26, 2015 Every year many ... to fight heart disease.  Nevertheless, year after year doctors ... (EKG) as the first test to determine the status ... chest pain or not, even though that technology is ... the fact that doctors know, (while most patients do ...
Breaking Medicine Technology:Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2National Heart Health Month In February 2
Cached News: