HOME >> MEDICINE >> NEWS
Jefferson researchers discover that nanoparticle shows promise in reducing radiation side effects

-protective agent, CD60_DF1.

To test how well it worked, they turned to tiny zebrafish embryos, which are transparent for the first month of life and allow scientists to observe closely organ damage produced by cancer treatments. Zebrafish have most of their organs formed by the third day after fertilization.

They gave the embryos different doses of ionizing radiation as well as treatment by either Amifostine, which acted as a control agent, or CD60_DF1. First, they found that CD60_DF1 had almost no toxicity. Then, they saw that CD60_DF1 given before and even immediately after--up to 30 minutes--exposure to X-rays reduced organ damage by one-half to two-thirds, which was as good as the level of protection given by Amifostine.

"We also showed that the fullerene provided organ-specific protection," Dr. Dicker notes. "It protected the kidney from radiation-induced damage, for example, as well as certain parts of the nervous system."

He explains that one way that radiation frequently damages cells and tissues is by producing "reactive oxygen species"--oxygen radicals, peroxides and hydroxyls. The scientists showed that zebrafish embryos exposed to ionizing radiation had more than 50 percent reduction in the production of reactive oxygen species compared to untreated embryos.

Dr. Dicker says that the company has technology enabling certain molecules to be attached to the nanoparticles, which will allow for targeting to specific tissue and organs, further enhancing use of the nanoparticles.

Dr. Dicker and his team plan follow-up studies using mouse models that will allow them to find out whether fullerene protects the entire animal from radiation, and how it works to protect specific organs. They also are interested in exploring its ability to prevent long-term side effects of radiation, such as fibrosis.


'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
5-Apr-2006


Page: 1 2

Related medicine news :

1. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
2. Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
3. Jefferson immunology researchers show blood-brain barrier damage could affect MS severity
4. Jefferson scientists find that plavix appears to be safe during and after heart bypass
5. Treatment of in-hospital cardiac patients is focus of Jefferson University presentations
6. Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
7. Empathy skills must be given a high priority in medical education, says Jefferson author
8. Natural, soy-based substance might help fight MS, Jefferson neuroscientists find
9. Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
10. Obesity tied to higher risk of complications in spinal surgery, Jefferson neurosurgeon finds
11. Jefferson Orthopaedic surgeons leading international study of timing of spinal surgery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... ... July 21, 2017 , ... The Ellis Agency, an eastern ... Epilepsy Foundation in a community wide charity event with the goal of bringing in ... young local woman who lives with epilepsy, recently launched a charity campaign of her ...
(Date:7/21/2017)... ... July 21, 2017 , ... Adolfson & Peterson Construction (AP) ... Ramsey County Medical Examiners Facility located in Saint Paul, Minn. A single story, ... scheduled to start in late 2017/early 2018. , Staffed by 20 full-time ...
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... Hospital M&A ... HealthCareMandA.com . The number of hospital acquisitions rose to 23 in the second ... 2017, and up 15% from the 20 announced deals in the year-ago second quarter. ...
(Date:7/21/2017)... ... ... at The House of Yahweh in Abilene, Texas, has written a new post this week ... leaders to be more open about positive changes. Yisrayl says the use of force is ... and positive way to solve all; yes, all issues, and he is ready to share ...
(Date:7/21/2017)... MO (PRWEB) , ... July 21, 2017 , ... “Kids ... knowing how to tie their shoes,” says Suzanne Tucker, Founder of St. Louis-based positive ... Time-In Toolkit, which launches on Kickstarter on Monday, July 21st. , The kit ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
(Date:7/13/2017)... , July 13, 2017  Centurion Medical Products, a leader in ... DisImpactor ® fecal impaction removal device for hospice patient care. ... Centurion Medical ... Patient pain management and emotional comfort ... can help alleviate patient pain while preventing unneeded emergency department admission ...
(Date:7/13/2017)... ROCKVILLE, Md. , July 13, 2017  New York ... watchers of pharmaceutical markets should be aware of.  From new ... These trends are detailed in a recently completed study, ... following: 1.  Age-Driven ... years, we have been aware of the impact the growing ...
Breaking Medicine Technology:
Cached News: