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Johns Hopkins Children's Center to lead largest-ever study on kidney disease in children

at measures glomerular filtration rate (GFR). GFR, which measures the kidneys' filtering capacity, is the most precise indicator of kidney function and status.

The new, improved method, which measures how fast the kidneys clear an injected contrast agent from the blood, promises to become the new gold standard for kidney function estimates in clinical trials and will also help researchers refine existing GFR-estimate formulas that doctors use for children. The current methods for estimating GFR yield faulty results in children 25 percent of the time.

Kidney disease in children tends to start and evolve silently. More than one-third (37 percent) of kidney transplant patients in 2001 were between the ages of 20 and 44, and the majority of them likely developed the disease in childhood, researchers say. Researchers estimate that 650,000 Americans will develop end-stage renal disease by 2010, costing the health care system $28 billion a year.


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Contact: Katerina Pesheva
epeshev1@jhmi.edu
410-516-4996
Johns Hopkins Medical Institutions
26-Jul-2006


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